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CATH Superfamily 3.50.50.60

FAD/NAD(P)-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
FAD/NAD(P)-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 112259: 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic a...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-(3-hydroxy-phenyl)propanoic acid hydroxylase. [EC: 1.14.13.127]
(1) 3-(3-hydroxyphenyl)propanoate + NADH + O(2) = 3-(2,3- dihydroxyphenyl)propanoate + H(2)O + NAD(+). (2) (2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + O(2) = (2E)-3-(2,3- dihydroxyphenyl)prop-2-enoate + H(2)O + NAD(+).
  • This enzyme participates in a meta-cleavage pathway employed by the bacterium Escherichia coli for the degradation of various phenylpropanoid compounds.
  • Formerly EC 1.14.13.n3.
 608 A0A009FF10 A0A023C944 A0A023V7X2 A0A023YT23 A0A024K473 A0A024KTS0 A0A024M736 A0A025CA56 A0A026RZ44 A0A026V5K3
(598 more...)
3-carboxyethylcatechol 2,3-dioxygenase. [EC: 1.13.11.16]
(1) 3-(2,3-dihydroxyphenyl)propanoate + O(2) = (2Z,4E)-2-hydroxy-6- oxonona-2,4-diene-1,9-dioate. (2) (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O(2) = (2Z,4E,7E)-2- hydroxy-6-oxonona-2,4,7-triene-1,9-dioate.
  • This enzyme catalyzes a step in the pathway of phenylpropanoid compounds degradation.
 1 X8CPM3
Pentachlorophenol monooxygenase. [EC: 1.14.13.50]
(1) Pentachlorophenol + NADPH + O(2) = 2,3,5,6-tetrachloro-1,4- benzoquinone + NADP(+) + chloride + H(2)O. (2) 2,3,5,6-tetrachlorophenol + NADPH + O(2) = 2,3,5,6- tetrachlorohydroquinone + NADP(+) + H(2)O.
  • The enzyme displaces a diverse range of substituents from the 4-position of polyhalogenated phenols but requires that a halogen substituent be present at the 2-position.
  • If C-4 carries a halogen substituent, reaction 1 is catalyzed; if C-4 is unsubstituted, reaction 2 is catalyzed.
 1 M7NA90