The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 63364: Aromatic amino acid aminotransferase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aromatic-amino-acid:2-oxoglutarate aminotransferase activity GO:0008793
Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.
4 A0A1D8PG20 (/IDA) P38840 (/IDA) P53090 (/IDA) Q6FTM8 (/IDA)
Aromatic-amino-acid:2-oxoglutarate aminotransferase activity GO:0008793
Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.
3 O14192 (/ISO) O94570 (/ISO) Q9Y7S6 (/ISO)
Kynurenine-oxoglutarate transaminase activity GO:0016212
Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
3 Q5E9N4 (/ISS) Q64602 (/ISS) Q9WVM8 (/ISS)
2-aminoadipate transaminase activity GO:0047536
Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate.
3 A0A1D8PG20 (/IDA) P53090 (/IDA) Q8N5Z0 (/IDA)
2-aminoadipate transaminase activity GO:0047536
Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate.
3 Q5E9N4 (/ISS) Q64602 (/ISS) Q9WVM8 (/ISS)
Aromatic-amino-acid:2-oxoglutarate aminotransferase activity GO:0008793
Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.
2 A0A1D8PG20 (/ISS) P38840 (/ISS)
Aromatic-amino-acid:2-oxoglutarate aminotransferase activity GO:0008793
Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.
2 Q5AZE2 (/RCA) Q5B339 (/RCA)
Kynurenine-oxoglutarate transaminase activity GO:0016212
Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
2 Q64602 (/IDA) Q8N5Z0 (/IDA)
Transaminase activity GO:0008483
Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
1 Q6FTM8 (/IDA)
Transaminase activity GO:0008483
Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
1 Q64602 (/TAS)
Kynurenine-oxoglutarate transaminase activity GO:0016212
Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
1 Q9WVM8 (/ISO)
Kynurenine-oxoglutarate transaminase activity GO:0016212
Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
1 Q8N5Z0 (/TAS)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
1 Q64602 (/IMP)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q8N5Z0 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9WVM8 (/ISO)
2-aminoadipate transaminase activity GO:0047536
Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate.
1 Q8N5Z0 (/EXP)
2-aminoadipate transaminase activity GO:0047536
Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate.
1 Q9WVM8 (/ISO)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
2-oxoglutarate metabolic process GO:0006103
The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
3 Q5E9N4 (/ISS) Q64602 (/ISS) Q9WVM8 (/ISS)
Glutamate metabolic process GO:0006536
The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
3 Q5E9N4 (/ISS) Q64602 (/ISS) Q9WVM8 (/ISS)
Aromatic amino acid family metabolic process GO:0009072
The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
3 O14192 (/ISO) O94570 (/ISO) Q9Y7S6 (/ISO)
Kynurenine metabolic process GO:0070189
The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine.
3 Q5E9N4 (/ISS) Q64602 (/ISS) Q9WVM8 (/ISS)
Aromatic amino acid family metabolic process GO:0009072
The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
2 P38840 (/IGI) P53090 (/IGI)
Aromatic amino acid family metabolic process GO:0009072
The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
2 P38840 (/IMP) P53090 (/IMP)
Aromatic amino acid family biosynthetic process GO:0009073
The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
2 Q5AZE2 (/RCA) Q5B339 (/RCA)
Aromatic amino acid family catabolic process to alcohol via Ehrlich pathway GO:0000949
The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.
1 A0A1D8PG20 (/ISS)
2-oxoglutarate metabolic process GO:0006103
The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
1 Q8N5Z0 (/IDA)
2-oxoglutarate metabolic process GO:0006103
The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
1 Q9WVM8 (/ISO)
Cellular amino acid metabolic process GO:0006520
The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
1 G4MR74 (/RCA)
Glutamate metabolic process GO:0006536
The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
1 Q8N5Z0 (/IDA)
Glutamate metabolic process GO:0006536
The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
1 Q9WVM8 (/ISO)
Lysine catabolic process GO:0006554
The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid.
1 Q8N5Z0 (/TAS)
Tryptophan catabolic process GO:0006569
The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.
1 Q8N5Z0 (/TAS)
Tryptophan catabolic process to kynurenine GO:0019441
The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine.
1 Q64602 (/IDA)
Histidine catabolic process to 2-oxoglutarate GO:0019558
The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including 2-oxoglutarate.
1 Q6FTM8 (/IDA)
Histidine catabolic process to 2-oxoglutarate GO:0019558
The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including 2-oxoglutarate.
1 Q6FTM8 (/IMP)
Pigment biosynthetic process GO:0046148
The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin.
1 Q6FTM8 (/IMP)
Kynurenine metabolic process GO:0070189
The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine.
1 Q8N5Z0 (/IDA)
Kynurenine metabolic process GO:0070189
The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine.
1 Q9WVM8 (/ISO)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 O14192 (/IDA) O94570 (/IDA) Q9Y7S6 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 O14192 (/ISO) O94570 (/ISO) Q9Y7S6 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 O14192 (/ISO) O94570 (/ISO) Q9Y7S6 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 O14192 (/IDA) O94570 (/IDA) Q9Y7S6 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q64602 (/IDA) Q9WVM8 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q8N5Z0 (/TAS)
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