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CATH Superfamily 3.40.640.10

Type I PLP-dependent aspartate aminotransferase-like (Major domain)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 63364: Aromatic amino acid aminotransferase

There are 9 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-aminoadipate transaminase. [EC: 2.6.1.39]
L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.
    		 262 A0A031WGG4 A0A060VB30 A0A069BGC9 A0A069RJP1 A0A073IAP9 A0A076JLC4 A0A078TNI2 A0A084A1K5 A0A086BPK2 A0A086ZH65
    (252 more...)
    Aspartate transaminase. [EC: 2.6.1.1]
    L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
    • Also acts on L-tyrosine, L-phenylalanine and L-tryptophan.
    • This activity can be formed from EC 2.6.1.57 by controlled proteolysis.
    		 112 A0A031GQR1 A0A085G459 A0A085G905 A0A085II10 A0A0A1DNM6 A0A0A1FJJ2 A0A0A1HTF1 A0A0C1PNN6 A0A0C4YAX8 A0A0C4YFP4
    (102 more...)
    Aromatic-amino-acid transaminase. [EC: 2.6.1.57]
    An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.
    • L-methionine can also act as donor, more slowly.
    • Oxaloacetate can act as acceptor.
    • Controlled proteolysis converts the enzyme to EC 2.6.1.1.
    		 60 A0A063BBE9 A0A075K8K8 A0A087E2D0 A0A0A8WYV8 A0A0F4YMG2 A0A0F8BK36 A0A0F8CTQ7 A0A0G4JSK9 A0A0H5CRS0 A0A0K3BG82
    (50 more...)
    Valine--pyruvate transaminase. [EC: 2.6.1.66]
    L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine.
    • Different from EC 2.6.1.42.
    		 18 A0A069BGC9 A0A0E1UM16 A0A0E1VU03 A0A0F6G7J5 A0A0F6L0U7 A0A0H3HTY9 A0A0J9E4U0 A3GF91 A3GGR2 A3LMX7
    (8 more...)
    Kynurenine--oxoglutarate transaminase. [EC: 2.6.1.7]
    L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
    • Also acts on 3-hydroxykynurenine.
    • The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
    		 9 H6Q7G5 N1P167 P38840 Q4W5N8 Q5E9N4 Q64602 Q8N5Z0 Q9WVM8 V3TMF3
    Alanine--glyoxylate transaminase. [EC: 2.6.1.44]
    L-alanine + glyoxylate = pyruvate + glycine.
    • With one component of the animal enzyme, 2-oxobutanoate can replace glyoxylate.
    • A second component also catalyzes the reaction of EC 2.6.1.51.
    		 6 B0VFF3 F2BVW8 H3ZJV8 Q9C4M4 Q9YFT1 U3T7V6
    Tyrosine transaminase. [EC: 2.6.1.5]
    L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.
    • L-phenylalanine can act instead of L-tyrosine.
    • The mitochondrial enzyme may be identical with EC 2.6.1.1.
    • The three isoenzymic forms are interconverted by EC 3.4.22.32 and EC 3.4.22.33.
    • The enzyme can also catalyze the final step in the methionine-salvage pathway of Klebsiella pneumoniae.
    		 2 A2QUB8 B7STY2
    Tryptophan transaminase. [EC: 2.6.1.27]
    L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate.
    • Also acts on 5-hydroxytryptophan and, to a lesser extent, on the phenyl amino acids.
    		 1 S4UF58
    Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
    NTP + H(2)O = NDP + phosphate.
    • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
    • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
    • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
    		 1 A0A0L1HCN9
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