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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 291477: Pentafunctional AROM polypeptide 2

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-phosphoshikimate 1-carboxyvinyltransferase. [EC: 2.5.1.19]
Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O- (1-carboxyvinyl)-3-phosphoshikimate.
    		 532 A0A010RP22 A0A017S5L2 A0A022VZT9 A0A022XQ62 A0A024RVA1 A0A059J9X2 A0A060S9A7 A0A060T792 A0A061B2K6 A0A061HAC0
    (522 more...)
    Shikimate dehydrogenase. [EC: 1.1.1.25]
    Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.
    • NAD(+) cannot replace NADP(+).
    • In higher organisms, this enzyme forms part of a multienzyme complex with EC 4.2.1.10.
    		 521 A0A010RP22 A0A017S5L2 A0A024RVA1 A0A059J9X2 A0A060S9A7 A0A060T792 A0A061B2K6 A0A061HAC0 A0A066WEQ3 A0A066X883
    (511 more...)
    3-dehydroquinate dehydratase. [EC: 4.2.1.10]
    3-dehydroquinate = 3-dehydroshikimate + H(2)O.
      		 512 A0A010RP22 A0A017S5L2 A0A024RVA1 A0A059J9X2 A0A060S9A7 A0A060T792 A0A061B2K6 A0A061HAC0 A0A066WEQ3 A0A066X883
      (502 more...)
      Shikimate kinase. [EC: 2.7.1.71]
      ATP + shikimate = ADP + shikimate 3-phosphate.
        		 511 A0A010RP22 A0A017S5L2 A0A024RVA1 A0A059J9X2 A0A060S9A7 A0A060T792 A0A061B2K6 A0A061HAC0 A0A066WEQ3 A0A066X883
        (501 more...)
        3-dehydroquinate synthase. [EC: 4.2.3.4]
        3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate.
        • The hydrogen atoms on C-7 of the substrate are retained on C-2 of the products.
        • Formerly EC 4.6.1.3.
        		 509 A0A010RP22 A0A017S5L2 A0A024RVA1 A0A059J9X2 A0A060S9A7 A0A060T792 A0A061B2K6 A0A061HAC0 A0A066WEQ3 A0A066X883
        (499 more...)
        Quinate dehydrogenase. [EC: 1.1.1.24]
        Quinate + NAD(+) = 3-dehydroquinate + NADH.
        • The enzyme is specific for quinate as substrate; phenylpyruvate, phenylalanine, cinnamate and shikimate will not act as substrates.
        • NAD(+) cannot be replaced by NADP(+).
        		 9 A0A0B0DV26 A0A0F4YNF5 A0A0F8AZG7 A2QGL3 A2QJS5 G3Y783 P11635 P25415 Q6MYX5
        Quinate/shikimate dehydrogenase. [EC: 1.1.1.282]
        (1) L-quinate + NAD(P)(+) = 3-dehydroquinate + NAD(P)H. (2) Shikimate + NAD(P)(+) = 3-dehydroshikimate + NAD(P)H.
        • This is the second shikimate dehydrogenase enzyme found in Escherichia coli and differs from EC 1.1.1.25, in that it can use both quinate and shikimate as substrate and either NAD(+) or NADP(+) as acceptor.
        		 2 A0A0L1HU34 A0A0L1I021