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CATH Superfamily 3.40.50.10860

Leucine Dehydrogenase, chain A, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Leucine Dehydrogenase, chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8334: Shikimate dehydrogenase (NADP(+))

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Shikimate dehydrogenase. [EC: 1.1.1.25]
Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.
  • NAD(+) cannot replace NADP(+).
  • In higher organisms, this enzyme forms part of a multienzyme complex with EC 4.2.1.10.
 2505 A0A010RS62 A0A011A9U8 A0A011QSK9 A0A014MQV8 A0A015KJB4 A0A022N9D3 A0A023CXC2 A0A023D9X1 A0A023XT64 A0A024EFI3
(2495 more...)
Shikimate kinase. [EC: 2.7.1.71]
ATP + shikimate = ADP + shikimate 3-phosphate.
    		 20 A0A0E2HEM7 A0A0F0C6S8 A0A0J9BV07 A0A0U5PN42 A0A174GNI6 A0A1C5M0Y6 A0A1C5TTI1 A0A1C7GET4 A0A1D9P3G3 A0A1H5SCT4
    (10 more...)
    Quinate/shikimate dehydrogenase. [EC: 1.1.1.282]
    (1) L-quinate + NAD(P)(+) = 3-dehydroquinate + NAD(P)H. (2) Shikimate + NAD(P)(+) = 3-dehydroshikimate + NAD(P)H.
    • This is the second shikimate dehydrogenase enzyme found in Escherichia coli and differs from EC 1.1.1.25, in that it can use both quinate and shikimate as substrate and either NAD(+) or NADP(+) as acceptor.
    		 11 A0A085G6L7 A0A085GXW4 A0A085HXJ3 A0A0L0RKH4 A0A198GX37 G2S6Q5 T0U3S8 T0VH34 W1DHM2 W1EGS9
    (1 more...)
    Quinate dehydrogenase. [EC: 1.1.1.24]
    Quinate + NAD(+) = 3-dehydroquinate + NADH.
    • The enzyme is specific for quinate as substrate; phenylpyruvate, phenylalanine, cinnamate and shikimate will not act as substrates.
    • NAD(+) cannot be replaced by NADP(+).
    		 7 A0A072Z5G5 A0A0E0UQN5 A0A0F6Z3Y2 A0A0S2T1T5 A4QB65 Q9X5C9 W4ACL2
    3-dehydroquinate dehydratase. [EC: 4.2.1.10]
    3-dehydroquinate = 3-dehydroshikimate + H(2)O.
      		 2 A0A0M2UUI9 Q1Q0M3
      Deleted entry. [EC: 1.3.99.1]
        		1 G6F7J5
        Fumarate reductase (quinol). [EC: 1.3.5.4]
        Succinate + a quinone = fumarate + a quinol.
        • The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain.
        • The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, to which it is closely related.
        		 1 A0A0U5KE13