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CATH Superfamily 3.40.50.10860

Leucine Dehydrogenase, chain A, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Leucine Dehydrogenase, chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8218: C-1-tetrahydrofolate synthase, cytoplasmic

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Methylenetetrahydrofolate dehydrogenase (NADP(+)). [EC: 1.5.1.5]
5,10-methylenetetrahydrofolate + NADP(+) = 5,10- methenyltetrahydrofolate + NADPH.
    		 40 A0A060T747 A0A060T8K2 A0A061HZ51 A0A0B4K623 A0A0L1HZ59 A0A0Q9WEX5 A0A0Q9WV13 A0A0R1E5B0 A0A0R1E6P9 A0A0R3NK86
    (30 more...)
    Formate--tetrahydrofolate ligase. [EC: 6.3.4.3]
    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
    • In eukaryotes occurs as a trifunctional enzyme also having EC 1.5.1.5 and EC 3.5.4.9 activity.
    		 39 A0A060T747 A0A060T8K2 A0A0B4K623 A0A0J5SS29 A0A0L1HZ59 A0A0Q9WEX5 A0A0Q9WV13 A0A0R1E5B0 A0A0R1E6P9 A0A0R3NK86
    (29 more...)
    Methenyltetrahydrofolate cyclohydrolase. [EC: 3.5.4.9]
    5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.
      		 19 A0A060T747 A0A060T8K2 A0A0B4K623 A2QEV9 A6ZUL4 B9WMA2 E8NH74 N1P634 N1P8D0 O43007
      (9 more...)
      Acireductone synthase. [EC: 3.1.3.77]
      5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O = 1,2-dihydroxy-5- (methylthio)pent-1-en-3-one + phosphate.
      • This bifunctional enzyme first enolizes the substrate to form the intermediate 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate, which is then dephosphorylated to form the acireductone 1,2- dihydroxy-5-(methylthio)pent-1-en-3-one.
      • The acireductone represents a branch point in the methione salvage pathway as it is used in the formation of formate, CO and 3-(methylthio)propanoate by EC 1.13.11.53 and of formate and 4-methylthio-2-oxobutanoate either by a spontaneous reaction under aerobic conditions or by EC 1.13.11.54.
      		 1 T1JKV3
      Methionyl-tRNA formyltransferase. [EC: 2.1.2.9]
      10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).
        		 1 A0A0L1HZ59
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