The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Leucine Dehydrogenase, chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8197: Bifunctional protein FolD protein

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Methylenetetrahydrofolate dehydrogenase (NADP(+)). [EC: 1.5.1.5]
5,10-methylenetetrahydrofolate + NADP(+) = 5,10- methenyltetrahydrofolate + NADPH.
    434 A0A017H4P5 A0A017PLK8 A0A024H284 A0A059FN72 A0A059HWX8 A0A059I3B9 A0A059IVK5 A0A060PZF2 A0A061JEN3 A0A064AJJ0
    (424 more...)
    Methenyltetrahydrofolate cyclohydrolase. [EC: 3.5.4.9]
    5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.
      434 A0A017H4P5 A0A017PLK8 A0A024H284 A0A059FN72 A0A059HWX8 A0A059I3B9 A0A059IVK5 A0A060PZF2 A0A061JEN3 A0A064AJJ0
      (424 more...)
      Formate--tetrahydrofolate ligase. [EC: 6.3.4.3]
      ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
      • In eukaryotes occurs as a trifunctional enzyme also having EC 1.5.1.5 and EC 3.5.4.9 activity.
      1 B9WKK3
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