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CATH Superfamily 3.40.50.10860

Leucine Dehydrogenase, chain A, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Leucine Dehydrogenase, chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8003: Branched-chain amino acid dehydrogenase

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Leucine dehydrogenase. [EC: 1.4.1.9]
L-leucine + H(2)O + NAD(+) = 4-methyl-2-oxopentanoate + NH(3) + NADH.
  • Also acts on isoleucine, valine, norvaline and norleucine.
 497 A0A011PRX2 A0A011Q777 A0A011RIX7 A0A023DEM5 A0A023P9U1 A0A031H5X4 A0A059FM15 A0A059FPR1 A0A062V3T0 A0A063X8N1
(487 more...)
Phenylalanine dehydrogenase. [EC: 1.4.1.20]
L-phenylalanine + H(2)O + NAD(+) = phenylpyruvate + NH(3) + NADH.
  • The enzymes from Bacillus badius and Sporosarcina ureae are highly specific for L-phenylalanine; that from Bacillus sphaericus also acts on L-tyrosine.
 22 A0A0C2YAC7 A0A0D8BX58 A0A0F6BLJ2 A0A0M1QKV8 A0A0N0I7N1 A0A0Q0ZDJ3 A0A160FCT4 A0A1L5IQK3 B5AYT3 D9RY85
(12 more...)
Glutamate dehydrogenase (NADP(+)). [EC: 1.4.1.4]
L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH.
    		 17 A0A063X8N1 A0A0G3VBQ2 A0A0T8PUG9 A0A0T9K3B9 A0A0U0CRK9 A0A142F699 A0A199WKJ0 A0A1L3PUU9 A0A1M9HX71 A0A1N7GFK4
    (7 more...)
    Valine dehydrogenase (NAD(+)). [EC: 1.4.1.23]
    L-valine + H(2)O + NAD(+) = 3-methyl-2-oxobutanoate + NH(3) + NADH.
    • The enzyme from Streptomyces spp. has no activity with NADP(+) (cf. EC 1.4.1.8).
    		 13 A0A062X0K9 A0A089Z035 A0A0C1P430 A0A0J8AGC8 A0A1A9GI45 A0A1B2GUY0 A0A1D2I526 A0A1H2CA88 A0A1I9ZGR7 D6EL34
    (3 more...)
    Short-chain acyl-CoA dehydrogenase. [EC: 1.3.8.1]
    A short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
    • One of several enzymes that catalyze the first step in fatty acids beta-oxidation.
    • The enzyme catalyzes the oxidation of saturated short-chain acyl-CoA thioesters to give a trans 2,3-unsaturated product by removal of the two pro-R-hydrogen atoms.
    • The enzyme from beef liver accepts substrates with acyl chain lengths of 3 to 8 carbon atoms.
    • The highest activity was reported with either butanoyl-CoA or pentanoyl-CoA.
    • The enzyme from rat has only 10% activity with hexanoyl-CoA (compared to butanoyl-CoA) and no activity with octanoyl-CoA.
    • Cf. EC 1.3.8.7, EC 1.3.8.8 and EC 1.3.8.9.
    • Formerly EC 1.3.2.1 and EC 1.3.99.2.
    		 12 A0A0H4RKU0 A0A0J6SYH3 A0A0M0WS38 A0A0Q6HLJ9 A0A0Q9G987 A0A0Q9HXR2 A0A0Q9VCV7 A0A109FYP4 A0A1G6LGU1 D5DLD0
    (2 more...)
    Valine dehydrogenase (NADP(+)). [EC: 1.4.1.8]
    L-valine + H(2)O + NADP(+) = 3-methyl-2-oxobutanoate + NH(3) + NADPH.
      		 9 A0A0G3VBQ2 A0A0U0CRK9 A0A0U1E7B0 A0A142F699 A0A1L3PUU9 A0A1N7GFK4 A7Z6H1 Q26ES9 S6FTB9
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