The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
HAD superfamily/HAD-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 57641: Lipin, isoform G

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription coactivator activity GO:0003713
Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
9 A0A0B4JCQ5 (/ISS) A0A0B4JCS1 (/ISS) A0A0B4JD00 (/ISS) A0A0B4JD27 (/ISS) A0A0B4JD31 (/ISS) A8DY69 (/ISS) E5DK16 (/ISS) I0E2I4 (/ISS) Q8SXP0 (/ISS)
Phosphatidate phosphatase activity GO:0008195
Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
9 A0A0B4JCQ5 (/ISS) A0A0B4JCS1 (/ISS) A0A0B4JD00 (/ISS) A0A0B4JD27 (/ISS) A0A0B4JD31 (/ISS) A8DY69 (/ISS) E5DK16 (/ISS) I0E2I4 (/ISS) Q8SXP0 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q91ZP3 (/IPI) Q9UUJ6 (/IPI)
Phosphatidate phosphatase activity GO:0008195
Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
2 P32567 (/IDA) Q91ZP3 (/IDA)
Phosphatidate phosphatase activity GO:0008195
Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
2 Q91ZP3 (/ISO) Q9UUJ6 (/ISO)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 Q9UUJ6 (/ISM)
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
1 Q91ZP3 (/IDA)
Transcription coactivator activity GO:0003713
Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
1 Q91ZP3 (/IDA)
Phosphatidate phosphatase activity GO:0008195
Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
1 Q14693 (/EXP)
Phosphatidate phosphatase activity GO:0008195
Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
1 P32567 (/IMP)
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
1 Q91ZP3 (/IDA)
Peroxisome proliferator activated receptor binding GO:0042975
Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma.
1 Q91ZP3 (/IPI)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 P32567 (/IDA)

There are 45 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Triglyceride biosynthetic process GO:0019432
The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.
10 A0A0B4JCQ5 (/IMP) A0A0B4JCS1 (/IMP) A0A0B4JD00 (/IMP) A0A0B4JD27 (/IMP) A0A0B4JD31 (/IMP) A8DY69 (/IMP) E5DK16 (/IMP) I0E2I4 (/IMP) P32567 (/IMP) Q8SXP0 (/IMP)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
9 A0A0B4JCQ5 (/ISS) A0A0B4JCS1 (/ISS) A0A0B4JD00 (/ISS) A0A0B4JD27 (/ISS) A0A0B4JD31 (/ISS) A8DY69 (/ISS) E5DK16 (/ISS) I0E2I4 (/ISS) Q8SXP0 (/ISS)
Imaginal disc-derived wing vein specification GO:0007474
The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified.
9 A0A0B4JCQ5 (/IMP) A0A0B4JCS1 (/IMP) A0A0B4JD00 (/IMP) A0A0B4JD27 (/IMP) A0A0B4JD31 (/IMP) A8DY69 (/IMP) E5DK16 (/IMP) I0E2I4 (/IMP) Q8SXP0 (/IMP)
Regulation of cellular ketone metabolic process GO:0010565
Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
9 A0A0B4JCQ5 (/IMP) A0A0B4JCS1 (/IMP) A0A0B4JD00 (/IMP) A0A0B4JD27 (/IMP) A0A0B4JD31 (/IMP) A8DY69 (/IMP) E5DK16 (/IMP) I0E2I4 (/IMP) Q8SXP0 (/IMP)
Regulation of fatty acid metabolic process GO:0019217
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.
9 A0A0B4JCQ5 (/IMP) A0A0B4JCS1 (/IMP) A0A0B4JD00 (/IMP) A0A0B4JD27 (/IMP) A0A0B4JD31 (/IMP) A8DY69 (/IMP) E5DK16 (/IMP) I0E2I4 (/IMP) Q8SXP0 (/IMP)
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
9 A0A0B4JCQ5 (/IGI) A0A0B4JCS1 (/IGI) A0A0B4JD00 (/IGI) A0A0B4JD27 (/IGI) A0A0B4JD31 (/IGI) A8DY69 (/IGI) E5DK16 (/IGI) I0E2I4 (/IGI) Q8SXP0 (/IGI)
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
9 A0A0B4JCQ5 (/IMP) A0A0B4JCS1 (/IMP) A0A0B4JD00 (/IMP) A0A0B4JD27 (/IMP) A0A0B4JD31 (/IMP) A8DY69 (/IMP) E5DK16 (/IMP) I0E2I4 (/IMP) Q8SXP0 (/IMP)
Response to starvation GO:0042594
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
9 A0A0B4JCQ5 (/IMP) A0A0B4JCS1 (/IMP) A0A0B4JD00 (/IMP) A0A0B4JD27 (/IMP) A0A0B4JD31 (/IMP) A8DY69 (/IMP) E5DK16 (/IMP) I0E2I4 (/IMP) Q8SXP0 (/IMP)
Lipid homeostasis GO:0055088
Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
9 A0A0B4JCQ5 (/IMP) A0A0B4JCS1 (/IMP) A0A0B4JD00 (/IMP) A0A0B4JD27 (/IMP) A0A0B4JD31 (/IMP) A8DY69 (/IMP) E5DK16 (/IMP) I0E2I4 (/IMP) Q8SXP0 (/IMP)
Phospholipid biosynthetic process GO:0008654
The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
2 Q9FMN2 (/IGI) Q9SF47 (/IGI)
Galactolipid biosynthetic process GO:0019375
The chemical reactions and pathways resulting in the formation of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine.
2 Q9FMN2 (/IGI) Q9SF47 (/IGI)
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
2 A0A0G2JW03 (/IEP) Q5XIM8 (/IEP)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
2 A0A0G2JW03 (/IDA) Q5XIM8 (/IDA)
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q91ZP3 (/IGI)
Mitochondrial fission GO:0000266
The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
1 Q91ZP3 (/IDA)
Plasmid maintenance GO:0006276
The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division.
1 P32567 (/IMP)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
1 Q9SF47 (/IGI)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
1 Q91ZP3 (/IMP)
Triglyceride mobilization GO:0006642
The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism.
1 Q91ZP3 (/IDA)
Triglyceride mobilization GO:0006642
The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism.
1 Q14693 (/ISS)
Phosphatidylethanolamine biosynthetic process GO:0006646
The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
1 Q14693 (/TAS)
Phosphatidylcholine biosynthetic process GO:0006656
The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
1 Q14693 (/TAS)
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
1 Q9SF47 (/IDA)
Nucleus organization GO:0006997
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.
1 Q9UUJ6 (/IMP)
Endoplasmic reticulum organization GO:0007029
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum.
1 Q9UUJ6 (/IMP)
Mitotic nuclear envelope disassembly GO:0007077
The cell cycle process in which the controlled breakdown of the nuclear envelope during mitotic cell division occurs.
1 Q14693 (/TAS)
Phospholipid biosynthetic process GO:0008654
The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
1 P32567 (/IMP)
Aerobic respiration GO:0009060
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
1 P32567 (/IMP)
Fatty acid catabolic process GO:0009062
The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
1 Q91ZP3 (/IDA)
Fatty acid catabolic process GO:0009062
The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
1 Q14693 (/ISS)
Cellular response to phosphate starvation GO:0016036
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate.
1 Q9SF47 (/IGI)
Triglyceride biosynthetic process GO:0019432
The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.
1 P32567 (/IGI)
Triglyceride biosynthetic process GO:0019432
The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.
1 Q9UUJ6 (/ISO)
Triglyceride biosynthetic process GO:0019432
The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.
1 Q14693 (/TAS)
Positive regulation of histone deacetylation GO:0031065
Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones.
1 Q91ZP3 (/IMP)
Ruffle organization GO:0031529
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.
1 Q91ZP3 (/IMP)
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q91ZP3 (/IMP)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 Q91ZP3 (/IMP)
Lipid particle organization GO:0034389
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle.
1 P32567 (/IGI)
Lipid particle organization GO:0034389
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle.
1 P32567 (/IMP)
Vacuole fusion, non-autophagic GO:0042144
The fusion of two vacuole membranes to form a single vacuole.
1 P32567 (/IMP)
Fat cell differentiation GO:0045444
The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
1 Q91ZP3 (/NAS)
Regulation of fat cell differentiation GO:0045598
Any process that modulates the frequency, rate or extent of adipocyte differentiation.
1 Q91ZP3 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q91ZP3 (/IDA)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q91ZP3 (/IGI)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 A0A0B4JCQ5 (/IDA) A0A0B4JCS1 (/IDA) A0A0B4JD00 (/IDA) A0A0B4JD27 (/IDA) A0A0B4JD31 (/IDA) A8DY69 (/IDA) E5DK16 (/IDA) I0E2I4 (/IDA) Q8SXP0 (/IDA) Q91ZP3 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 A0A0B4JCQ5 (/IDA) A0A0B4JCS1 (/IDA) A0A0B4JD00 (/IDA) A0A0B4JD27 (/IDA) A0A0B4JD31 (/IDA) A8DY69 (/IDA) E5DK16 (/IDA) I0E2I4 (/IDA) Q8SXP0 (/IDA) Q91ZP3 (/IDA)
Female germline ring canal inner rim GO:0035183
A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins.
9 A0A0B4JCQ5 (/IDA) A0A0B4JCS1 (/IDA) A0A0B4JD00 (/IDA) A0A0B4JD27 (/IDA) A0A0B4JD31 (/IDA) A8DY69 (/IDA) E5DK16 (/IDA) I0E2I4 (/IDA) Q8SXP0 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P32567 (/IDA) Q9UUJ6 (/IDA)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
2 P32567 (/IDA) Q91ZP3 (/IDA)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
1 Q9SF47 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q14693 (/ISS)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 Q14693 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q14693 (/TAS)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
1 Q91ZP3 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9UUJ6 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q14693 (/ISS)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 Q91ZP3 (/IDA)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
1 P32567 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q14693 (/TAS)
Lipid particle GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
1 P32567 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9FMN2 (/IDA)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 P32567 (/IDA)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
1 Q14693 (/ISS)
Protein storage vacuole membrane GO:0032586
The lipid bilayer surrounding a protein storage vacuole.
1 Q9SF47 (/IDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
1 Q9FMN2 (/IDA)