The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 43715: Pre-mRNA-splicing factor SLT11, putative

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 21 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
11 F4I3B3 (/IDA) O13759 (/IDA) P32831 (/IDA) Q0WW84 (/IDA) Q5ARJ0 (/IDA) Q93W34 (/IDA) Q9FPJ8 (/IDA) Q9LNV5 (/IDA) Q9SAB3 (/IDA) Q9SX79 (/IDA)
(1 more)
U6 snRNA binding GO:0017070
Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA).
9 Q3B7L8 (/ISS) Q4R4J1 (/ISS) Q4V7D7 (/ISS) Q5RAY5 (/ISS) Q5ZM16 (/ISS) Q6NZZ9 (/ISS) Q6P616 (/ISS) Q7ZXB5 (/ISS) Q8BHS3 (/ISS)
Pre-mRNA binding GO:0036002
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.
9 Q3B7L8 (/ISS) Q4R4J1 (/ISS) Q4V7D7 (/ISS) Q5RAY5 (/ISS) Q5ZM16 (/ISS) Q6NZZ9 (/ISS) Q6P616 (/ISS) Q7ZXB5 (/ISS) Q8BHS3 (/ISS)
Poly(A) binding GO:0008143
Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
7 F4I3B3 (/ISS) Q0WW84 (/ISS) Q93W34 (/ISS) Q9FPJ8 (/ISS) Q9SAB3 (/ISS) Q9SX79 (/ISS) Q9SX80 (/ISS)
Nucleocytoplasmic transporter activity GO:0005487
Enables the directed movement of substances between the nucleus and the cytoplasm of a cell.
6 Q3B7L8 (/ISS) Q4R4J1 (/ISS) Q4V7D7 (/ISS) Q5RAY5 (/ISS) Q5ZM16 (/ISS) Q8BHS3 (/ISS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 Q9NW64 (/IDA) Q9SAB3 (/IDA)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
2 O13759 (/ISO) O60176 (/ISO)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
2 Q5ARJ0 (/ISS) Q95RB1 (/ISS)
Poly(A) binding GO:0008143
Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
2 Q9LEB3 (/IDA) Q9LEB4 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q00539 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q8BHS3 (/ISO)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 Q00539 (/IPI)
Nucleocytoplasmic transporter activity GO:0005487
Enables the directed movement of substances between the nucleus and the cytoplasm of a cell.
1 Q9NW64 (/IDA)
Nucleocytoplasmic transporter activity GO:0005487
Enables the directed movement of substances between the nucleus and the cytoplasm of a cell.
1 Q8BHS3 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 O13759 (/IPI)
U6 snRNA binding GO:0017070
Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA).
1 Q9NW64 (/IDA)
U6 snRNA binding GO:0017070
Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA).
1 Q8BHS3 (/ISO)
Pre-mRNA binding GO:0036002
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.
1 Q9NW64 (/IDA)
Pre-mRNA binding GO:0036002
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.
1 Q8BHS3 (/ISO)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
1 Q9NW64 (/IPI)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
1 Q8BHS3 (/ISO)

There are 35 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of RNA splicing GO:0033120
Any process that activates or increases the frequency, rate or extent of RNA splicing.
9 Q3B7L8 (/ISS) Q4R4J1 (/ISS) Q4V7D7 (/ISS) Q5RAY5 (/ISS) Q5ZM16 (/ISS) Q6NZZ9 (/ISS) Q6P616 (/ISS) Q7ZXB5 (/ISS) Q8BHS3 (/ISS)
MRNA cis splicing, via spliceosome GO:0045292
The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.
9 Q3B7L8 (/ISS) Q4R4J1 (/ISS) Q4V7D7 (/ISS) Q5RAY5 (/ISS) Q5ZM16 (/ISS) Q6NZZ9 (/ISS) Q6P616 (/ISS) Q7ZXB5 (/ISS) Q8BHS3 (/ISS)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
6 Q3B7L8 (/ISS) Q4R4J1 (/ISS) Q4V7D7 (/ISS) Q5RAY5 (/ISS) Q5ZM16 (/ISS) Q8BHS3 (/ISS)
Positive regulation of intracellular protein transport GO:0090316
Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells.
6 Q3B7L8 (/ISS) Q4R4J1 (/ISS) Q4V7D7 (/ISS) Q5RAY5 (/ISS) Q5ZM16 (/ISS) Q8BHS3 (/ISS)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
4 F4I3B3 (/ISS) Q0WW84 (/ISS) Q9SX79 (/ISS) Q9SX80 (/ISS)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
2 Q95RB1 (/IC) Q9NW64 (/IC)
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
2 F4I3B3 (/IDA) Q9SAB3 (/IDA)
Protein import into nucleus, translocation GO:0000060
A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope.
1 Q9NW64 (/IDA)
Protein import into nucleus, translocation GO:0000060
A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope.
1 Q8BHS3 (/ISO)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
1 Q95RB1 (/IMP)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
1 Q00539 (/IPI)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
1 Q9NW64 (/TAS)
MRNA splice site selection GO:0006376
Selection of a splice site by components of the assembling spliceosome.
1 Q00539 (/IMP)
MRNA splice site selection GO:0006376
Selection of a splice site by components of the assembling spliceosome.
1 O60176 (/ISO)
Arginine catabolic process GO:0006527
The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
1 Q5ARJ0 (/IMP)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
1 P32831 (/IMP)
Response to ozone GO:0010193
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus.
1 Q9SAB3 (/IEP)
Positive regulation of RNA splicing GO:0033120
Any process that activates or increases the frequency, rate or extent of RNA splicing.
1 Q9NW64 (/IDA)
Positive regulation of RNA splicing GO:0033120
Any process that activates or increases the frequency, rate or extent of RNA splicing.
1 Q8BHS3 (/ISO)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
1 Q9LEB3 (/IDA)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q9NW64 (/IDA)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q8BHS3 (/ISO)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 Q9LNV5 (/IGI)
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
1 Q6NZZ9 (/IMP)
MRNA cis splicing, via spliceosome GO:0045292
The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.
1 Q9NW64 (/IDA)
MRNA cis splicing, via spliceosome GO:0045292
The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.
1 Q8BHS3 (/ISO)
Positive regulation of mRNA splicing, via spliceosome GO:0048026
Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism.
1 Q00539 (/IMP)
Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213
Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.
1 Q5ARJ0 (/IMP)
3'-UTR-mediated mRNA destabilization GO:0061158
An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.
1 P32831 (/IDA)
3'-UTR-mediated mRNA destabilization GO:0061158
An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.
1 P32831 (/IMP)
3'-UTR-mediated mRNA stabilization GO:0070935
An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.
1 O13759 (/ISO)
Positive regulation of intracellular protein transport GO:0090316
Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells.
1 Q9NW64 (/IDA)
Positive regulation of intracellular protein transport GO:0090316
Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells.
1 Q8BHS3 (/ISO)
Positive regulation of cellular response to oxidative stress GO:1900409
Any process that activates or increases the frequency, rate or extent of cellular response to oxidative stress.
1 Q5ARJ0 (/IMP)
Regulation of mRNA stability involved in response to oxidative stress GO:2000815
A process of regulation of mRNA stability that is involved in a response to oxidative stress.
1 O13759 (/IMP)

There are 22 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
15 F4I3B3 (/ISS) Q0WW84 (/ISS) Q3B7L8 (/ISS) Q4R4J1 (/ISS) Q4V7D7 (/ISS) Q5RAY5 (/ISS) Q5ZM16 (/ISS) Q6P616 (/ISS) Q7ZXB5 (/ISS) Q8BHS3 (/ISS)
(5 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 Q3B7L8 (/ISS) Q4R4J1 (/ISS) Q4V7D7 (/ISS) Q5RAY5 (/ISS) Q5ZM16 (/ISS) Q6NZZ9 (/ISS) Q6P616 (/ISS) Q7ZXB5 (/ISS) Q8BHS3 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 Q00539 (/IDA) Q22412 (/IDA) Q6NZZ9 (/IDA) Q9LEB3 (/IDA) Q9LEB4 (/IDA) Q9LNV5 (/IDA) Q9NW64 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 F4I3B3 (/IDA) O13759 (/IDA) O60176 (/IDA) Q0WW84 (/IDA) Q5ARJ0 (/IDA) Q93W34 (/IDA) Q9FPJ8 (/IDA)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
4 O13759 (/IDA) P32831 (/IDA) Q0WW84 (/IDA) Q9LEB3 (/IDA)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
4 F4I3B3 (/ISS) Q0WW84 (/ISS) Q9SX79 (/ISS) Q9SX80 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 O13759 (/IDA) Q00539 (/IDA) Q9NW64 (/IDA)
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
2 O13759 (/ISO) O60176 (/ISO)
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
2 Q95RB1 (/IDA) Q9NW64 (/IDA)
Commitment complex GO:0000243
A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript.
1 Q00539 (/IPI)
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
1 P32831 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q95RB1 (/IC)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8BHS3 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9NW64 (/TAS)
U1 snRNP GO:0005685
A ribonucleoprotein complex that contains small nuclear RNA U1.
1 Q00539 (/IDA)
U1 snRNP GO:0005685
A ribonucleoprotein complex that contains small nuclear RNA U1.
1 O60176 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8BHS3 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P32831 (/IDA)
U2-type prespliceosome GO:0071004
A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation.
1 Q00539 (/IDA)
U2-type prespliceosome GO:0071004
A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation.
1 O60176 (/ISO)
Precatalytic spliceosome GO:0071011
A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs.
1 Q95RB1 (/IDA)
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
1 Q8BHS3 (/ISO)
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