View in Gene3D

CATH Superfamily 3.30.70.330

RRM (RNA recognition motif) domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 43661: Peptidyl-prolyl cis-trans isomerase-like 4

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Peptidylprolyl isomerase. [EC: 5.2.1.8]
Peptidylproline (omega=180) = peptidylproline (omega=0).
  • The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A.
  • Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli.
  • The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
 108 A0A059LCB3 A0A059LCB3 A0A061IFE9 A0A061IFE9 A0A067FXD7 A0A067FXD7 A0A0B0DYG5 A0A0B0DYG5 A0A0B2P5Z6 A0A0B2P5Z6
(98 more...)
Transferred entry: 1.4.3.21 and 1.4.3.22. [EC: 1.4.3.6]
    		4 B6AB76 B6AB76 E0VKH4 E0VKH4
    RNA-directed RNA polymerase. [EC: 2.7.7.48]
    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
    • Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.
    • Can initiate a chain de novo.
    • See also EC 2.7.7.6.
    		 2 I1CD10 I1CD10