The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 43620: Nucleolysin TIA-1 isoform p40

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 P31483 (/IPI) P70318 (/IPI) Q03735 (/IPI) Q09702 (/IPI) Q09702 (/IPI) Q80ZW7 (/IPI)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
5 A0A126GV08 (/ISS) A8JPX0 (/ISS) E1JJ00 (/ISS) Q8IMX4 (/ISS) Q9VCE3 (/ISS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
4 P31483 (/IDA) Q01085 (/IDA) Q09702 (/IDA) Q09702 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 P52912 (/ISO) P70318 (/ISO)
Poly(U) RNA binding GO:0008266
Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule.
2 Q09702 (/IDA) Q09702 (/IDA)
AU-rich element binding GO:0017091
Interacting selectively and non-covalently with a region of RNA containing frequent adenine and uridine bases.
2 P52912 (/IDA) P70318 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 O13674 (/NAS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q01085 (/TAS)
Poly(A) binding GO:0008143
Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
1 P31483 (/TAS)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
7 A0A0B4KH70 (/IMP) A0A0B4KHB5 (/IMP) A0A0B4LIU0 (/IMP) E1JIZ9 (/IMP) Q8IMX4 (/IMP) Q9VAX3 (/IMP) Q9VCE3 (/IMP)
Positive regulation of dendrite morphogenesis GO:0050775
Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
5 A0A0B4KH70 (/IMP) A0A0B4KHB5 (/IMP) A0A0B4LIU0 (/IMP) E1JIZ9 (/IMP) Q9VAX3 (/IMP)
Detection of temperature stimulus involved in sensory perception of pain GO:0050965
The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal.
5 A0A0B4KH70 (/IMP) A0A0B4KHB5 (/IMP) A0A0B4LIU0 (/IMP) E1JIZ9 (/IMP) Q9VAX3 (/IMP)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
2 Q8IMX4 (/ISS) Q9VCE3 (/ISS)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
2 P31483 (/TAS) Q01085 (/TAS)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
2 P31483 (/TAS) Q01085 (/TAS)
Negative regulation of conjugation with cellular fusion GO:0031138
Any process that decreases the rate or frequency of conjugation with cellular fusion.
2 Q09702 (/IMP) Q09702 (/IMP)
Regulation of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter GO:1900406
A regulation of transcription from RNA polymerase II promoter that results in regulation of conjugation with cellular fusion.
2 Q09702 (/IMP) Q09702 (/IMP)
Negative regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter GO:1902625
A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of induction of conjugation with cellular fusion.
2 Q09702 (/IMP) Q09702 (/IMP)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
1 Q08925 (/IGI)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
1 Q08925 (/IGI)
Regulation of transcription from RNA polymerase II promoter GO:0006357
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q01085 (/TAS)
Defense response GO:0006952
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
1 Q01085 (/TAS)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
1 P70318 (/IMP)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P70318 (/IMP)
Stem cell division GO:0017145
The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types.
1 P70318 (/IMP)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
1 P52912 (/IMP)
Negative regulation of cytokine biosynthetic process GO:0042036
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.
1 P52912 (/IMP)
Regulation of mRNA splicing, via spliceosome GO:0048024
Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism.
1 P31483 (/IDA)
Regulation of mRNA splicing, via spliceosome GO:0048024
Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism.
1 P52912 (/ISO)
Protein localization to cytoplasmic stress granule GO:1903608
A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule.
1 P31483 (/IMP)
Protein localization to cytoplasmic stress granule GO:1903608
A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule.
1 P52912 (/ISO)
Positive regulation of epithelial cell apoptotic process GO:1904037
Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process.
1 Q5PQR7 (/IMP)

There are 22 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 P31483 (/IDA) P52912 (/IDA) P70318 (/IDA) Q08925 (/IDA) Q09702 (/IDA) Q09702 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 P52912 (/IDA) P70318 (/IDA) Q08925 (/IDA) Q5BJN3 (/IDA) Q5PQR7 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 F8W8I6 (/IDA) O13674 (/IDA) P31483 (/IDA) Q09702 (/IDA) Q09702 (/IDA)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
5 P31483 (/IDA) P52912 (/IDA) P70318 (/IDA) Q03735 (/IDA) Q08925 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q8IMX4 (/IC) Q9VCE3 (/IC)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 F8W8I6 (/IDA) P31483 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 P31483 (/TAS) Q01085 (/TAS)
U1 snRNP GO:0005685
A ribonucleoprotein complex that contains small nuclear RNA U1.
2 Q8IMX4 (/ISS) Q9VCE3 (/ISS)
Intracellular ribonucleoprotein complex GO:0030529
An intracellular macromolecular complex containing both protein and RNA molecules.
2 Q5BJN3 (/IDA) Q5PQR7 (/IDA)
Nuclear stress granule GO:0097165
A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress.
2 P31483 (/IDA) P52912 (/IDA)
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
1 Q08925 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q01085 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P52912 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P52912 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q01085 (/ISS)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 Q01085 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P52912 (/ISO)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
1 P52912 (/ISO)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
1 Q01085 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q01085 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P70318 (/ISO)
Nuclear stress granule GO:0097165
A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress.
1 P52912 (/ISO)
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