The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 43555: Eukaryotic translation initiation factor 4B
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
|
7 | Q7KUX7 (/ISS) Q8IHF2 (/ISS) Q8IR13 (/ISS) Q9VA45 (/ISS) Q9VXF8 (/ISS) X2JC79 (/ISS) X2JE34 (/ISS) |
|
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
|
7 | Q7KUX7 (/ISS) Q8IHF2 (/ISS) Q8IR13 (/ISS) Q9VA45 (/ISS) Q9VXF8 (/ISS) X2JC79 (/ISS) X2JE34 (/ISS) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
2 | P23588 (/IDA) Q15056 (/IDA) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
2 | Q8BGD9 (/ISO) Q9WUK2 (/ISO) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
2 | P23588 (/TAS) Q15056 (/TAS) |
|
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
|
2 | P23588 (/TAS) Q15056 (/TAS) |
|
Helicase activity GO:0004386
Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix.
|
2 | P23588 (/TAS) Q15056 (/TAS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P23588 (/IPI) Q15056 (/IPI) |
|
Translation factor activity, RNA binding GO:0008135
Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome.
|
1 | Q15056 (/TAS) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
1 | Q15056 (/IDA) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
1 | Q9WUK2 (/ISO) |
There are 6 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
7 | Q7KUX7 (/ISS) Q8IHF2 (/ISS) Q8IR13 (/ISS) Q9VA45 (/ISS) Q9VXF8 (/ISS) X2JC79 (/ISS) X2JE34 (/ISS) |
|
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
2 | P23588 (/TAS) Q15056 (/TAS) |
|
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
|
2 | P23588 (/TAS) Q15056 (/TAS) |
|
Nuclear-transcribed mRNA poly(A) tail shortening GO:0000289
Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
|
1 | P23588 (/TAS) |
|
Sexual reproduction GO:0019953
A reproduction process that creates a new organism by combining the genetic material of two organisms. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two different individuals (parents) join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny.
|
1 | Q9WUK2 (/IMP) |
|
Developmental growth GO:0048589
The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
|
1 | Q9WUK2 (/IMP) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
7 | Q7KUX7 (/ISS) Q8IHF2 (/ISS) Q8IR13 (/ISS) Q9VA45 (/ISS) Q9VXF8 (/ISS) X2JC79 (/ISS) X2JE34 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P23588 (/TAS) Q15056 (/TAS) |
|
Eukaryotic translation initiation factor 4F complex GO:0016281
The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
|
2 | P23588 (/TAS) Q15056 (/TAS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q15056 (/IDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q9WUK2 (/ISO) |
|
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
1 | Q5RKG9 (/IDA) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
1 | Q5RKG9 (/IDA) |
