The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 43388: Peroxisome proliferator-activated receptor gamma c...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 35 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
30 A9YWH5 (/ISS) D0VE08 (/ISS) E2QWA6 (/ISS) E5KXH9 (/ISS) F6WDA2 (/ISS) F6XM07 (/ISS) F6YR50 (/ISS) F7GQV9 (/ISS) F7ISR8 (/ISS) G1LVA6 (/ISS)
(20 more)
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
30 A9YWH5 (/ISS) D0VE08 (/ISS) E2QWA6 (/ISS) E5KXH9 (/ISS) F6WDA2 (/ISS) F6XM07 (/ISS) F6YR50 (/ISS) F7GQV9 (/ISS) F7ISR8 (/ISS) G1LVA6 (/ISS)
(20 more)
Transcription coactivator activity GO:0003713
Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
28 A9YWH5 (/ISS) D0VE08 (/ISS) E2QWA6 (/ISS) E5KXH9 (/ISS) F6WDA2 (/ISS) F6XM07 (/ISS) F6YR50 (/ISS) F7GQV9 (/ISS) F7ISR8 (/ISS) G1LVA6 (/ISS)
(18 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 O70343 (/IPI) Q8VHJ7 (/IPI) Q9QYK2 (/IPI) Q9UBK2 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
4 O70343 (/ISS) Q865B6 (/ISS) Q865B7 (/ISS) Q9QYK2 (/ISS)
Transcription coactivator activity GO:0003713
Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
3 O70343 (/IDA) Q9QYK2 (/IDA) Q9UBK2 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
2 O70343 (/IPI) Q9QYK2 (/IPI)
Ligand-dependent nuclear receptor transcription coactivator activity GO:0030374
The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.
2 O70343 (/ISO) Q8VHJ7 (/ISO)
Ligand-dependent nuclear receptor transcription coactivator activity GO:0030374
The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.
2 Q811R2 (/ISS) Q8VHJ7 (/ISS)
AF-2 domain binding GO:0050682
Interacting selectively and non-covalently with the AF-2 domain of a protein, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation.
2 Q811R2 (/ISS) Q8VHJ7 (/ISS)
RNA polymerase II transcription cofactor activity GO:0001104
Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery.
1 Q8VHJ7 (/ISO)
RNA polymerase II transcription cofactor activity GO:0001104
Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery.
1 Q9UBK2 (/TAS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 O70343 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q9UBK2 (/TAS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q9QYK2 (/IDA)
Transcription coactivator activity GO:0003713
Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
1 O70343 (/IMP)
Transcription coactivator activity GO:0003713
Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
1 O70343 (/ISO)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q9UBK2 (/TAS)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
1 Q9UBK2 (/TAS)
Ligand-dependent nuclear receptor binding GO:0016922
Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein.
1 Q9UBK2 (/IPI)
Ligand-dependent nuclear receptor binding GO:0016922
Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein.
1 O70343 (/ISO)
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
1 Q9QYK2 (/IPI)
Estrogen receptor binding GO:0030331
Interacting selectively and non-covalently with an estrogen receptor.
1 Q8VHJ7 (/ISO)
Ligand-dependent nuclear receptor transcription coactivator activity GO:0030374
The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.
1 Q9UBK2 (/IDA)
Receptor activator activity GO:0030546
The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased.
1 Q8VHJ7 (/ISO)
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
1 O70343 (/IDA)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 Q9UBK2 (/IPI)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 O70343 (/ISO)
Peroxisome proliferator activated receptor binding GO:0042975
Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma.
1 Q9QYK2 (/IPI)
Alpha-tubulin binding GO:0043014
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
1 Q9QYK2 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 Q9UBK2 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 O70343 (/ISO)
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
1 Q9UBK2 (/NAS)
AF-2 domain binding GO:0050682
Interacting selectively and non-covalently with the AF-2 domain of a protein, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation.
1 Q8VHJ7 (/ISO)
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
1 Q9QYK2 (/IDA)

There are 141 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
32 A9YWH5 (/ISS) D0VE08 (/ISS) E2QWA6 (/ISS) E5KXH9 (/ISS) F6WDA2 (/ISS) F6XM07 (/ISS) F6YR50 (/ISS) F7GQV9 (/ISS) F7ISR8 (/ISS) G1LVA6 (/ISS)
(22 more)
Positive regulation of mitochondrion organization GO:0010822
Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.
30 A9YWH5 (/ISS) D0VE08 (/ISS) E2QWA6 (/ISS) E5KXH9 (/ISS) F6WDA2 (/ISS) F6XM07 (/ISS) F6YR50 (/ISS) F7GQV9 (/ISS) F7ISR8 (/ISS) G1LVA6 (/ISS)
(20 more)
Response to muscle activity GO:0014850
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus.
30 A9YWH5 (/ISS) D0VE08 (/ISS) E2QWA6 (/ISS) E5KXH9 (/ISS) F6WDA2 (/ISS) F6XM07 (/ISS) F6YR50 (/ISS) F7GQV9 (/ISS) F7ISR8 (/ISS) G1LVA6 (/ISS)
(20 more)
Respiratory electron transport chain GO:0022904
A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
30 A9YWH5 (/ISS) D0VE08 (/ISS) E2QWA6 (/ISS) E5KXH9 (/ISS) F6WDA2 (/ISS) F6XM07 (/ISS) F6YR50 (/ISS) F7GQV9 (/ISS) F7ISR8 (/ISS) G1LVA6 (/ISS)
(20 more)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
30 A9YWH5 (/ISS) D0VE08 (/ISS) E2QWA6 (/ISS) E5KXH9 (/ISS) F6WDA2 (/ISS) F6XM07 (/ISS) F6YR50 (/ISS) F7GQV9 (/ISS) F7ISR8 (/ISS) G1LVA6 (/ISS)
(20 more)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
30 A9YWH5 (/ISS) D0VE08 (/ISS) E2QWA6 (/ISS) E5KXH9 (/ISS) F6WDA2 (/ISS) F6XM07 (/ISS) F6YR50 (/ISS) F7GQV9 (/ISS) F7ISR8 (/ISS) G1LVA6 (/ISS)
(20 more)
Positive regulation of energy homeostasis GO:2000507
Any process that activates or increases the frequency, rate or extent of energy homeostasis.
30 A9YWH5 (/ISS) D0VE08 (/ISS) E2QWA6 (/ISS) E5KXH9 (/ISS) F6WDA2 (/ISS) F6XM07 (/ISS) F6YR50 (/ISS) F7GQV9 (/ISS) F7ISR8 (/ISS) G1LVA6 (/ISS)
(20 more)
Positive regulation of ATP biosynthetic process GO:2001171
Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process.
30 A9YWH5 (/ISS) D0VE08 (/ISS) E2QWA6 (/ISS) E5KXH9 (/ISS) F6WDA2 (/ISS) F6XM07 (/ISS) F6YR50 (/ISS) F7GQV9 (/ISS) F7ISR8 (/ISS) G1LVA6 (/ISS)
(20 more)
Positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
29 A9YWH5 (/ISS) D0VE08 (/ISS) E2QWA6 (/ISS) E5KXH9 (/ISS) F6WDA2 (/ISS) F6XM07 (/ISS) F6YR50 (/ISS) F7GQV9 (/ISS) F7ISR8 (/ISS) G1LVA6 (/ISS)
(19 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
28 A9YWH5 (/ISS) D0VE08 (/ISS) E2QWA6 (/ISS) E5KXH9 (/ISS) F6WDA2 (/ISS) F6XM07 (/ISS) F6YR50 (/ISS) F7GQV9 (/ISS) F7ISR8 (/ISS) G1LVA6 (/ISS)
(18 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
6 O70343 (/ISS) Q811R2 (/ISS) Q865B6 (/ISS) Q865B7 (/ISS) Q8VHJ7 (/ISS) Q9QYK2 (/ISS)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
4 Q865B6 (/ISS) Q865B7 (/ISS) Q9QYK2 (/ISS) Q9UBK2 (/ISS)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
4 Q865B6 (/ISS) Q865B7 (/ISS) Q9QYK2 (/ISS) Q9UBK2 (/ISS)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
4 O70343 (/ISS) Q865B6 (/ISS) Q865B7 (/ISS) Q9QYK2 (/ISS)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
3 O70343 (/TAS) Q8VHJ7 (/TAS) Q9UBK2 (/TAS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
3 O70343 (/IMP) Q8VHJ7 (/IMP) Q9QYK2 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 O70343 (/ISO) Q8VHJ7 (/ISO)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
2 O70343 (/TAS) Q9UBK2 (/TAS)
Positive regulation of mitochondrion organization GO:0010822
Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.
2 O70343 (/IMP) Q9UBK2 (/IMP)
Intracellular estrogen receptor signaling pathway GO:0030520
Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).
2 Q811R2 (/ISS) Q8VHJ7 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 O70343 (/IDA) Q9UBK2 (/IDA)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 O70343 (/IMP) Q9QYK2 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 O70343 (/ISO) Q8VHJ7 (/ISO)
Positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
2 O70343 (/IDA) Q9UBK2 (/IDA)
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
1 Q9QYK2 (/IEP)
Mitophagy GO:0000422
The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions.
1 Q9QYK2 (/IEP)
Ossification GO:0001503
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
1 Q8VHJ7 (/IMP)
Temperature homeostasis GO:0001659
A homeostatic process in which an organism modulates its internal body temperature.
1 Q9UBK2 (/TAS)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q9QYK2 (/IEP)
Cellular glucose homeostasis GO:0001678
A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.
1 Q9UBK2 (/NAS)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
1 Q9QYK2 (/IMP)
Response to dietary excess GO:0002021
The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure.
1 O70343 (/IDA)
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
1 Q9QYK2 (/IEP)
Galactose metabolic process GO:0006012
The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
1 Q9QYK2 (/IEP)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
1 Q9QYK2 (/IEP)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
1 Q9UBK2 (/NAS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9UBK2 (/IDA)
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
1 Q9UBK2 (/TAS)
Transcription from mitochondrial promoter GO:0006390
The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase.
1 Q8VHJ7 (/IMP)
MRNA processing GO:0006397
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
1 Q9UBK2 (/TAS)
Protein complex assembly GO:0006461
The aggregation, arrangement and bonding together of a set of components to form a protein complex.
1 Q9UBK2 (/TAS)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
1 Q9QYK2 (/IEP)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
1 Q9QYK2 (/IMP)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
1 Q9UBK2 (/NAS)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
1 Q8VHJ7 (/IMP)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
1 F1QXB5 (/IMP)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 Q9QYK2 (/IEP)
Digestion GO:0007586
The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
1 Q9UBK2 (/TAS)
Androgen metabolic process GO:0008209
The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.
1 Q9QYK2 (/IEP)
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
1 Q9UBK2 (/TAS)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
1 Q9QYK2 (/IEP)
Response to fructose GO:0009750
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus.
1 Q9QYK2 (/IEP)
Positive regulation of alkaline phosphatase activity GO:0010694
Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.
1 Q8VHJ7 (/IMP)
Positive regulation of mitochondrion organization GO:0010822
Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.
1 O70343 (/ISO)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 Q9QYK2 (/IEP)
Skeletal muscle atrophy GO:0014732
A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse.
1 Q9QYK2 (/IEP)
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
1 Q9QYK2 (/IDA)
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
1 Q9QYK2 (/IEP)
Response to muscle activity GO:0014850
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus.
1 O70343 (/IDA)
Response to muscle activity GO:0014850
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus.
1 Q9QYK2 (/IEP)
Response to muscle activity GO:0014850
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus.
1 O70343 (/IMP)
Response to electrical stimulus involved in regulation of muscle adaptation GO:0014878
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation.
1 Q9QYK2 (/IEP)
Negative regulation of smooth muscle cell migration GO:0014912
Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.
1 Q9QYK2 (/IMP)
Fatty acid oxidation GO:0019395
The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
1 Q9QYK2 (/IEP)
Fatty acid oxidation GO:0019395
The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
1 Q9UBK2 (/NAS)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
1 Q9QYK2 (/IEP)
Respiratory electron transport chain GO:0022904
A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
1 O70343 (/IDA)
Intracellular estrogen receptor signaling pathway GO:0030520
Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).
1 Q8VHJ7 (/ISO)
Androgen receptor signaling pathway GO:0030521
Any series of molecular signals generated as a consequence of an androgen binding to its receptor.
1 Q9UBK2 (/NAS)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
1 Q9QYK2 (/IEP)
Positive regulation of cellular metabolic process GO:0031325
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
1 Q9QYK2 (/IMP)
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
1 Q9QYK2 (/IEP)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
1 O70343 (/IDA)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 O70343 (/IMP)
Cellular response to reactive oxygen species GO:0034614
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
1 Q8VHJ7 (/IDA)
Positive regulation of histone acetylation GO:0035066
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.
1 Q9UBK2 (/TAS)
Cellular response to potassium ion GO:0035865
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus.
1 Q9QYK2 (/IEP)
Positive regulation of phosphorylation GO:0042327
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.
1 Q8VHJ7 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q9QYK2 (/IEP)
Response to starvation GO:0042594
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
1 Q9QYK2 (/IEP)
Response to starvation GO:0042594
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
1 Q9UBK2 (/NAS)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
1 O70343 (/IDA)
Response to leucine GO:0043201
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus.
1 Q9QYK2 (/IEP)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
1 O70343 (/IMP)
Cellular respiration GO:0045333
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).
1 Q9UBK2 (/TAS)
Positive regulation of osteoclast differentiation GO:0045672
Any process that activates or increases the frequency, rate or extent of osteoclast differentiation.
1 Q8VHJ7 (/IMP)
Positive regulation of gluconeogenesis GO:0045722
Any process that activates or increases the frequency, rate or extent of gluconeogenesis.
1 Q9UBK2 (/TAS)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
1 Q8VHJ7 (/IMP)
Negative regulation of glycolytic process GO:0045820
Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.
1 Q9QYK2 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8VHJ7 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 O70343 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9UBK2 (/NAS)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q9UBK2 (/IDA)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 O70343 (/IGI)
Positive regulation of fatty acid oxidation GO:0046321
Any process that activates or increases the frequency, rate or extent of fatty acid oxidation.
1 Q9QYK2 (/IMP)
Positive regulation of fatty acid oxidation GO:0046321
Any process that activates or increases the frequency, rate or extent of fatty acid oxidation.
1 Q9UBK2 (/TAS)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
1 Q9QYK2 (/IMP)
Negative regulation of smooth muscle cell proliferation GO:0048662
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
1 Q9QYK2 (/IMP)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
1 Q9UBK2 (/TAS)
Brown fat cell differentiation GO:0050873
The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
1 Q9UBK2 (/TAS)
Positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 O70343 (/ISO)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 Q811R2 (/IEP)
Flavone metabolic process GO:0051552
The chemical reactions and pathways involving flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone).
1 Q9QYK2 (/IEP)
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 Q811R2 (/IEP)
Response to electrical stimulus GO:0051602
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
1 Q9QYK2 (/IEP)
Bone trabecula formation GO:0060346
The process of creating a trabecula in the bone. A trabecula is a tissue element in the form of a small beam, strut or rod.
1 Q8VHJ7 (/IMP)
Adipose tissue development GO:0060612
The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat.
1 O70343 (/IMP)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q9QYK2 (/IEP)
Cellular response to nitrite GO:0071250
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrite stimulus.
1 Q9QYK2 (/IEP)
Cellular response to caffeine GO:0071313
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
1 Q9QYK2 (/IEP)
Cellular response to fructose stimulus GO:0071332
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus.
1 Q9QYK2 (/IEP)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 Q9QYK2 (/IEP)
Cellular response to interleukin-6 GO:0071354
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.
1 Q9QYK2 (/IEP)
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 Q9QYK2 (/IEP)
Cellular response to follicle-stimulating hormone stimulus GO:0071372
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus.
1 Q9QYK2 (/IDA)
Cellular response to estradiol stimulus GO:0071392
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 Q9QYK2 (/IEP)
Cellular response to fatty acid GO:0071398
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
1 Q9QYK2 (/IEP)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q9QYK2 (/IEP)
Cellular response to transforming growth factor beta stimulus GO:0071560
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
1 Q9QYK2 (/IDA)
Response to epinephrine GO:0071871
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.
1 Q9QYK2 (/IEP)
Response to norepinephrine GO:0071873
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system.
1 Q9QYK2 (/IEP)
Negative regulation of mitochondrial fission GO:0090258
Any process that decreases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
1 Q9QYK2 (/IMP)
Response to thyroid hormone GO:0097066
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.
1 Q9QYK2 (/IEP)
Cellular response to thyroid hormone stimulus GO:0097067
A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.
1 Q9QYK2 (/IDA)
Cellular response to thyroid hormone stimulus GO:0097067
A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.
1 Q9QYK2 (/IEP)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 Q9UBK2 (/IGI)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 O70343 (/ISO)
Response to metformin GO:1901558
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metformin stimulus.
1 Q9QYK2 (/IEP)
Positive regulation of cellular respiration GO:1901857
Any process that activates or increases the frequency, rate or extent of cellular respiration.
1 O70343 (/IMP)
Positive regulation of mitochondrial DNA metabolic process GO:1901860
Any process that activates or increases the frequency, rate or extent of mitochondrial DNA metabolic process.
1 O70343 (/IMP)
Positive regulation of muscle tissue development GO:1901863
Any process that activates or increases the frequency, rate or extent of muscle tissue development.
1 O70343 (/IMP)
Positive regulation of glomerular visceral epithelial cell apoptotic process GO:1904635
Any process that activates or increases the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process.
1 Q9QYK2 (/IMP)
Cellular response to ionomycin GO:1904637
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus.
1 Q9QYK2 (/IEP)
Cellular response to resveratrol GO:1904639
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus.
1 Q9QYK2 (/IEP)
Response to methionine GO:1904640
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus.
1 Q9QYK2 (/IEP)
Adaptive thermogenesis GO:1990845
The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature.
1 Q9QYK2 (/IEP)
Positive regulation of progesterone biosynthetic process GO:2000184
Any process that activates or increases the frequency, rate or extent of progesterone biosynthetic process.
1 Q9QYK2 (/IMP)
Negative regulation of receptor activity GO:2000272
Any process that stops, prevents or reduces the frequency, rate or extent of receptor activity.
1 Q9QYK2 (/IMP)
Regulation of NMDA receptor activity GO:2000310
Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity.
1 Q9QYK2 (/IMP)
Positive regulation of energy homeostasis GO:2000507
Any process that activates or increases the frequency, rate or extent of energy homeostasis.
1 O70343 (/IMP)
Positive regulation of ATP biosynthetic process GO:2001171
Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process.
1 O70343 (/IMP)

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
31 A9YWH5 (/ISS) D0VE08 (/ISS) E2QWA6 (/ISS) E5KXH9 (/ISS) F6WDA2 (/ISS) F6XM07 (/ISS) F6YR50 (/ISS) F7GQV9 (/ISS) F7ISR8 (/ISS) G1LVA6 (/ISS)
(21 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 O70343 (/IDA) Q9QYK2 (/IDA) Q9UBK2 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 O70343 (/TAS) Q8VHJ7 (/TAS) Q9UBK2 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O70343 (/ISO) Q8VHJ7 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 A0A024R9Q9 (/IDA) Q9UBK2 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 A0A024R9Q9 (/IDA) Q9UBK2 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9UBK2 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 O70343 (/ISO)
DNA-directed RNA polymerase II, core complex GO:0005665
RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
1 Q9UBK2 (/TAS)
Nuclear euchromatin GO:0005719
The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.
1 Q9QYK2 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9QYK2 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9QYK2 (/IDA)
Mediator complex GO:0016592
A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
1 Q8VHJ7 (/ISO)
Cytosolic ribosome GO:0022626
A ribosome located in the cytosol.
1 Q9QYK2 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q9QYK2 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 O70343 (/ISO)
Apical dendrite GO:0097440
A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon.
1 Q9QYK2 (/IDA)
Subsarcolemmal mitochondrion GO:1990843
A mitochondrion that occurs adjacent to the sarcolemma in striated muscle cells and responds in distinct ways to physiological triggers.
1 Q9QYK2 (/IDA)
Interfibrillar mitochondrion GO:1990844
A mitochondrion that occurs in between fibrils of striated muscle cells and responds in distinct ways to physiological triggers.
1 Q9QYK2 (/IDA)
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