The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Nucleotide cyclase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5760: Adenylate cyclase type 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 33 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Adenylate cyclase activity GO:0004016
Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
25 A8JNU1 (/NAS) E1JIB3 (/NAS) M9NDN7 (/NAS) M9NG95 (/NAS) M9PBA8 (/NAS) M9PD54 (/NAS) M9PE08 (/NAS) M9PEP2 (/NAS) M9PG27 (/NAS) M9PH04 (/NAS)
(15 more)
Adenylate cyclase activity GO:0004016
Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
17 F1LQT1 (/IDA) M9PEP2 (/IDA) O43306 (/IDA) O60503 (/IDA) O95622 (/IDA) P21932 (/IDA) P26769 (/IDA) P26770 (/IDA) P51828 (/IDA) P51830 (/IDA)
(7 more)
Adenylate cyclase activity GO:0004016
Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
13 O16880 (/ISS) O60266 (/ISS) P30803 (/ISS) P30804 (/ISS) P40144 (/ISS) P51830 (/ISS) P98999 (/ISS) Q08462 (/ISS) Q19523 (/ISS) Q80TL1 (/ISS)
(3 more)
Adenylate cyclase activity GO:0004016
Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
11 O60266 (/TAS) O60503 (/TAS) O88444 (/TAS) P30803 (/TAS) P32870 (/TAS) P40145 (/TAS) P51829 (/TAS) Q08828 (/TAS) Q80TL1 (/TAS) Q8VHH7 (/TAS)
(1 more)
Adenylate cyclase activity GO:0004016
Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
8 M9NDN7 (/ISM) M9PBA8 (/ISM) M9PE08 (/ISM) Q9VK50 (/ISM) Q9VK51 (/ISM) Q9VK52 (/ISM) Q9VK53 (/ISM) Q9W038 (/ISM)
Calcium- and calmodulin-responsive adenylate cyclase activity GO:0008294
Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin.
8 D4A3N4 (/IDA) P19754 (/IDA) P21932 (/IDA) P32870 (/IDA) P40146 (/IDA) Q01341 (/IDA) Q03343 (/IDA) Q04400 (/IDA)
Adenylate cyclase activity GO:0004016
Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
7 M0R5U4 (/IMP) O95622 (/IMP) P51829 (/IMP) P84309 (/IMP) Q01341 (/IMP) Q03343 (/IMP) Q8VHH7 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 O43306 (/IPI) P26769 (/IPI) P40146 (/IPI) P84309 (/IPI) Q8NFM4 (/IPI) Q8VHH7 (/IPI)
Adenylate cyclase activity GO:0004016
Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
4 P51829 (/ISO) P51830 (/ISO) P84309 (/ISO) Q01341 (/ISO)
Calcium- and calmodulin-responsive adenylate cyclase activity GO:0008294
Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin.
4 P21932 (/IMP) P32870 (/IMP) P40146 (/IMP) Q03343 (/IMP)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
2 Q08462 (/ISS) Q80TL1 (/ISS)
Adenylate cyclase activity GO:0004016
Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
2 O88444 (/IGI) P97490 (/IGI)
Adenylate cyclase binding GO:0008179
Interacting selectively and non-covalently with the enzyme adenylate cyclase.
2 P84309 (/IPI) Q80TL1 (/IPI)
Adenylate cyclase binding GO:0008179
Interacting selectively and non-covalently with the enzyme adenylate cyclase.
2 O95622 (/ISS) Q08462 (/ISS)
Calcium- and calmodulin-responsive adenylate cyclase activity GO:0008294
Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin.
2 O88444 (/ISS) Q08828 (/ISS)
Calcium- and calmodulin-responsive adenylate cyclase activity GO:0008294
Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin.
2 P32870 (/TAS) P40145 (/TAS)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 O43306 (/ISS) Q01341 (/ISS)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
2 Q08462 (/ISS) Q80TL1 (/ISS)
G-protein beta/gamma-subunit complex binding GO:0031683
Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits.
2 P26769 (/IPI) P26770 (/IPI)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 P84309 (/IPI) Q80TL1 (/IPI)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 O95622 (/ISS) Q08462 (/ISS)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
2 P84309 (/IPI) Q01341 (/IPI)
SNARE binding GO:0000149
Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
1 Q03343 (/IDA)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 P26769 (/IDA)
Receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q03343 (/IPI)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
1 P40146 (/IDA)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 P40146 (/IDA)
Adenylate cyclase binding GO:0008179
Interacting selectively and non-covalently with the enzyme adenylate cyclase.
1 P26769 (/IDA)
Calcium- and calmodulin-responsive adenylate cyclase activity GO:0008294
Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin.
1 Q08828 (/NAS)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q03343 (/IDA)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
1 P26769 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 P26769 (/IDA)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 P40146 (/IDA)

There are 149 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
CAMP biosynthetic process GO:0006171
The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
17 D4A3N4 (/IDA) F1LQT1 (/IDA) M9PEP2 (/IDA) O43306 (/IDA) O60503 (/IDA) O95622 (/IDA) P19754 (/IDA) P21932 (/IDA) P26769 (/IDA) P26770 (/IDA)
(7 more)
Adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
15 O60266 (/ISS) O88444 (/ISS) P21932 (/ISS) P30803 (/ISS) P30804 (/ISS) P40144 (/ISS) P51830 (/ISS) P84309 (/ISS) P98999 (/ISS) Q03343 (/ISS)
(5 more)
Activation of adenylate cyclase activity GO:0007190
Any process that initiates the activity of the inactive enzyme adenylate cyclase.
14 O43306 (/TAS) O60266 (/TAS) O60503 (/TAS) O88444 (/TAS) O95622 (/TAS) P40145 (/TAS) P51828 (/TAS) P51829 (/TAS) Q08462 (/TAS) Q08828 (/TAS)
(4 more)
CAMP biosynthetic process GO:0006171
The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
11 O60266 (/ISS) O88444 (/ISS) P30803 (/ISS) P30804 (/ISS) P40144 (/ISS) P98999 (/ISS) Q08462 (/ISS) Q08828 (/ISS) Q80TL1 (/ISS) Q8NFM4 (/ISS)
(1 more)
Cellular response to forskolin GO:1904322
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus.
11 O60266 (/ISS) O88444 (/ISS) P30803 (/ISS) P30804 (/ISS) P40144 (/ISS) P84309 (/ISS) Q03343 (/ISS) Q04400 (/ISS) Q08462 (/ISS) Q08828 (/ISS)
(1 more)
Renal water homeostasis GO:0003091
Renal process involved in the maintenance of an internal steady state of water in the body.
9 O43306 (/TAS) O60266 (/TAS) O60503 (/TAS) O95622 (/TAS) P40145 (/TAS) P51828 (/TAS) Q08462 (/TAS) Q08828 (/TAS) Q8NFM4 (/TAS)
Adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
9 O43306 (/TAS) O60266 (/TAS) O60503 (/TAS) O95622 (/TAS) P40145 (/TAS) P51828 (/TAS) Q08462 (/TAS) Q08828 (/TAS) Q8NFM4 (/TAS)
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).
9 O43306 (/TAS) O60266 (/TAS) O60503 (/TAS) O95622 (/TAS) P40145 (/TAS) P51828 (/TAS) Q08462 (/TAS) Q08828 (/TAS) Q8NFM4 (/TAS)
Activation of protein kinase A activity GO:0034199
Any process that initiates the activity of the inactive enzyme protein kinase A.
9 O43306 (/TAS) O60266 (/TAS) O60503 (/TAS) O95622 (/TAS) P40145 (/TAS) P51828 (/TAS) Q08462 (/TAS) Q08828 (/TAS) Q8NFM4 (/TAS)
Cellular response to glucagon stimulus GO:0071377
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.
9 O43306 (/TAS) O60266 (/TAS) O60503 (/TAS) O95622 (/TAS) P40145 (/TAS) P51828 (/TAS) Q08462 (/TAS) Q08828 (/TAS) Q8NFM4 (/TAS)
Detection of chemical stimulus involved in sensory perception of sweet taste GO:0001582
The series of events required for a sweet taste stimulus to be received and converted to a molecular signal.
6 M9NG95 (/IMP) M9PD54 (/IMP) M9PG27 (/IMP) M9PID8 (/IMP) Q9VP76 (/IMP) Q9Y1V0 (/IMP)
CAMP biosynthetic process GO:0006171
The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
6 M0R5U4 (/IMP) O95622 (/IMP) P40146 (/IMP) Q01341 (/IMP) Q03343 (/IMP) Q8VHH7 (/IMP)
CAMP biosynthetic process GO:0006171
The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
6 O88444 (/TAS) P51829 (/TAS) P84309 (/TAS) Q80TL1 (/TAS) Q8VHH7 (/TAS) Q91WF3 (/TAS)
Response to sucrose GO:0009744
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus.
6 M9NG95 (/IDA) M9PD54 (/IDA) M9PG27 (/IDA) M9PID8 (/IDA) Q9VP76 (/IDA) Q9Y1V0 (/IDA)
Response to trehalose GO:0010353
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus.
6 M9NG95 (/IDA) M9PD54 (/IDA) M9PG27 (/IDA) M9PID8 (/IDA) Q9VP76 (/IDA) Q9Y1V0 (/IDA)
Axon midline choice point recognition GO:0016199
The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline.
6 B0S535 (/IGI) B0S536 (/IGI) B7UCF8 (/IGI) D1MIA3 (/IGI) F1QP02 (/IGI) F1R914 (/IGI)
Response to caffeine GO:0031000
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
6 M9NG95 (/IDA) M9PD54 (/IDA) M9PG27 (/IDA) M9PID8 (/IDA) Q9VP76 (/IDA) Q9Y1V0 (/IDA)
Retinal ganglion cell axon guidance GO:0031290
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
6 B0S535 (/IGI) B0S536 (/IGI) B7UCF8 (/IGI) D1MIA3 (/IGI) F1QP02 (/IGI) F1R914 (/IGI)
Adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
5 O43306 (/IDA) O60503 (/IDA) P19754 (/IDA) P26769 (/IDA) P51830 (/IDA)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
5 M9NDN7 (/IEP) M9PBA8 (/IEP) Q9VK51 (/IEP) Q9VK52 (/IEP) Q9VK53 (/IEP)
Adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
4 O95622 (/IMP) P40146 (/IMP) Q01341 (/IMP) Q8VHH7 (/IMP)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
4 P30803 (/ISS) P40144 (/ISS) P84309 (/ISS) Q04400 (/ISS)
Axon midline choice point recognition GO:0016199
The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline.
4 B0S535 (/IMP) B0S536 (/IMP) B7UCF8 (/IMP) F1QP02 (/IMP)
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
4 O88444 (/ISS) Q08462 (/ISS) Q08828 (/ISS) Q80TL1 (/ISS)
Myelination in peripheral nervous system GO:0022011
The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
4 E7FEP5 (/IGI) E9QDH0 (/IGI) F1R9C3 (/IGI) X1WHI1 (/IGI)
Retinal ganglion cell axon guidance GO:0031290
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
4 B0S535 (/IMP) B0S536 (/IMP) B7UCF8 (/IMP) F1QP02 (/IMP)
Regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178
Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
4 P30803 (/ISS) P40144 (/ISS) P84309 (/ISS) Q04400 (/ISS)
Cellular response to forskolin GO:1904322
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus.
4 O43306 (/IDA) O95622 (/IDA) P21932 (/IDA) P26769 (/IDA)
Renal water homeostasis GO:0003091
Renal process involved in the maintenance of an internal steady state of water in the body.
3 O43306 (/ISS) P30804 (/ISS) Q03343 (/ISS)
CAMP biosynthetic process GO:0006171
The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
3 P51830 (/ISO) P84309 (/ISO) Q01341 (/ISO)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
3 O60266 (/TAS) O60503 (/TAS) P40145 (/TAS)
Adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
3 P51830 (/ISO) P84309 (/ISO) Q01341 (/ISO)
Notum development GO:0007477
The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure.
3 E1JIB3 (/IMP) M9PH04 (/IMP) Q9W037 (/IMP)
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
3 P19754 (/IDA) P26769 (/IDA) P40146 (/IDA)
Chaeta development GO:0022416
The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell.
3 E1JIB3 (/IMP) M9PH04 (/IMP) Q9W037 (/IMP)
Negative regulation of urine volume GO:0035811
Any process that decreases the amount of urine excreted from the body over a unit of time.
3 O43306 (/ISS) P30804 (/ISS) Q03343 (/ISS)
Adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880
The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP).
3 P51830 (/ISS) P98999 (/ISS) Q9DGG6 (/ISS)
Cellular response to vasopressin GO:1904117
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus.
3 O43306 (/ISS) P30804 (/ISS) Q03343 (/ISS)
Cellular response to forskolin GO:1904322
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus.
3 P19754 (/IMP) Q01341 (/IMP) Q8VHH7 (/IMP)
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
2 O16880 (/IMP) Q19523 (/IMP)
Adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007188
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP).
2 P26769 (/IDA) Q91WF3 (/IDA)
Adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007188
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP).
2 O16880 (/IMP) Q19523 (/IMP)
Adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007188
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP).
2 Q08462 (/ISS) Q8NFM4 (/ISS)
Single fertilization GO:0007338
The union of male and female gametes to form a zygote.
2 O60266 (/ISS) P21932 (/ISS)
Acrosome reaction GO:0007340
The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the egg.
2 O60266 (/ISS) P21932 (/ISS)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
2 D1MIA3 (/IMP) F1R914 (/IMP)
Sensory perception of smell GO:0007608
The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
2 P21932 (/IDA) Q8VHH7 (/IDA)
Short-term memory GO:0007614
The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.
2 P32870 (/IMP) Q19523 (/IMP)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
2 O88444 (/IGI) P97490 (/IGI)
Olfactory learning GO:0008355
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.
2 O60266 (/ISS) P21932 (/ISS)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
2 Q01341 (/IMP) Q03343 (/IMP)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
2 O60266 (/ISS) P21932 (/ISS)
Sleep GO:0030431
Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.
2 P32870 (/IMP) Q19523 (/IMP)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2 P21932 (/IDA) P26770 (/IDA)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
2 P19754 (/ISS) Q08828 (/ISS)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
2 O88444 (/ISS) Q08828 (/ISS)
Cellular response to forskolin GO:1904322
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus.
2 P84309 (/ISO) Q01341 (/ISO)
Conditioned taste aversion GO:0001661
A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus.
1 P32870 (/IMP)
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
1 D2CFN3 (/IDA)
Adenosine receptor signaling pathway GO:0001973
The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.
1 P84309 (/IGI)
Instar larval or pupal development GO:0002165
The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster.
1 Q9VW60 (/IMP)
Renal water homeostasis GO:0003091
Renal process involved in the maintenance of an internal steady state of water in the body.
1 Q01341 (/IMP)
CAMP biosynthetic process GO:0006171
The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
1 P32870 (/NAS)
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 Q19523 (/IMP)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 P32870 (/IMP)
Female meiotic division GO:0007143
A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline.
1 P21932 (/IEP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 F1LQT1 (/NAS)
G-protein coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 Q966F9 (/ISS)
G-protein coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 P32870 (/TAS)
Adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007188
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP).
1 Q80TL1 (/TAS)
Adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
1 P84309 (/IGI)
Adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191
The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP).
1 P84309 (/IGI)
Adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195
The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).
1 P84309 (/IGI)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
1 O95622 (/IMP)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
1 P84309 (/ISO)
Dopamine receptor signaling pathway GO:0007212
The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.
1 O43306 (/IDA)
Dopamine receptor signaling pathway GO:0007212
The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.
1 Q01341 (/ISO)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a neuron, across a chemical synapse, the subsequent activation of neurotransmitter receptors of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 P32870 (/IMP)
Neuromuscular synaptic transmission GO:0007274
The process of communication from a neuron to a muscle, across a synapse.
1 P32870 (/IMP)
Single fertilization GO:0007338
The union of male and female gametes to form a zygote.
1 Q8VHH7 (/IMP)
Acrosome reaction GO:0007340
The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the egg.
1 Q8VHH7 (/IMP)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon.
1 O88444 (/IMP)
Neuromuscular junction development GO:0007528
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
1 P32870 (/IMP)
Molting cycle, chitin-based cuticle GO:0007591
The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster.
1 P32870 (/IGI)
Sensory perception of smell GO:0007608
The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
1 Q8VHH7 (/IMP)
Sensory perception of smell GO:0007608
The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
1 O60266 (/ISS)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
1 P32870 (/IMP)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
1 P32870 (/NAS)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
1 P40145 (/TAS)
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
1 P32870 (/IMP)
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
1 P32870 (/NAS)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
1 P32870 (/IMP)
Mating behavior GO:0007617
The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.
1 P32870 (/TAS)
Courtship behavior GO:0007619
The behavioral interactions between organisms for the purpose of attracting sexual partners.
1 P32870 (/TAS)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 D4A3N4 (/IEP)
Grooming behavior GO:0007625
The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites.
1 P32870 (/NAS)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
1 P84309 (/IMP)
Cell death GO:0008219
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
1 Q19523 (/IMP)
Associative learning GO:0008306
Learning by associating a stimulus (the cause) with a particular outcome (the effect).
1 P32870 (/IDA)
Associative learning GO:0008306
Learning by associating a stimulus (the cause) with a particular outcome (the effect).
1 P32870 (/IMP)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 P32870 (/IMP)
Olfactory learning GO:0008355
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.
1 Q8VHH7 (/IMP)
Olfactory learning GO:0008355
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.
1 P32870 (/NAS)
Olfactory learning GO:0008355
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.
1 P32870 (/TAS)
Cyclic nucleotide biosynthetic process GO:0009190
The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.
1 P32870 (/IDA)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
1 P32870 (/IMP)
Response to lithium ion GO:0010226
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.
1 D4A3N4 (/IEP)
Regulation of protein kinase A signaling GO:0010738
Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
1 P32870 (/IMP)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 O43306 (/ISS)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P40146 (/IEP)
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
1 P32870 (/NAS)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
1 Q8VHH7 (/IMP)
Positive regulation of cAMP biosynthetic process GO:0030819
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
1 P51828 (/IDA)
Positive regulation of cAMP biosynthetic process GO:0030819
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
1 F1LQT1 (/IMP)
Positive regulation of cAMP biosynthetic process GO:0030819
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
1 P51829 (/ISO)
Negative regulation of urine volume GO:0035811
Any process that decreases the amount of urine excreted from the body over a unit of time.
1 Q01341 (/IMP)
Negative regulation of multicellular organism growth GO:0040015
Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size.
1 Q9VW60 (/IMP)
Positive regulation of locomotion GO:0040017
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
1 Q19523 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 D4A3N4 (/IEP)
Response to starvation GO:0042594
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
1 Q9VW60 (/IDA)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
1 O88444 (/IMP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 D2CFN3 (/IMP)
Locomotor rhythm GO:0045475
The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
1 Q9V9R3 (/IMP)
Behavioral response to ethanol GO:0048149
Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.
1 P32870 (/IMP)
Behavioral response to ethanol GO:0048149
Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.
1 P32870 (/NAS)
Behavioral response to ethanol GO:0048149
Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.
1 P32870 (/TAS)
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
1 P32870 (/IMP)
Neuromuscular process controlling balance GO:0050885
Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.
1 P84309 (/IMP)
Maternal process involved in female pregnancy GO:0060135
A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.
1 F1LQT1 (/IEP)
Regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178
Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
1 O95622 (/IMP)
Regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178
Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
1 P84309 (/ISO)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
1 P19754 (/IDA)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
1 P40146 (/IEP)
Cellular response to ethanol GO:0071361
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P51828 (/IDA)
Cellular response to ethanol GO:0071361
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P51829 (/ISO)
Cellular response to prostaglandin E stimulus GO:0071380
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.
1 O43306 (/IDA)
Cellular response to prostaglandin E stimulus GO:0071380
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.
1 Q01341 (/ISO)
Cellular response to catecholamine stimulus GO:0071870
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol
1 O43306 (/IDA)
Cellular response to catecholamine stimulus GO:0071870
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol
1 Q01341 (/ISO)
Adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880
The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP).
1 O60503 (/IMP)
Adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880
The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP).
1 P51830 (/ISO)
Medium-term memory GO:0072375
The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster).
1 Q19523 (/IMP)
Maintenance of protein location in plasma membrane GO:0072660
Any process in which a protein is maintained in a specific location in the plasma membrane, and is prevented from moving elsewhere.
1 Q03343 (/IMP)
Regulation of olfactory learning GO:0090328
Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.
1 P32870 (/IMP)
Regulation of blood vessel diameter GO:0097746
Any process that modulates the diameter of blood vessels.
1 O43306 (/IMP)
Regulation of blood vessel diameter GO:0097746
Any process that modulates the diameter of blood vessels.
1 Q01341 (/ISO)
Positive regulation of oocyte maturation GO:1900195
Any process that activates or increases the frequency, rate or extent of oocyte maturation.
1 Q966F9 (/IMP)
Cellular response to vasopressin GO:1904117
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus.
1 Q01341 (/IMP)
Regulation of defecation GO:2000292
Any process that modulates the frequency, rate or extent of defecation.
1 Q19523 (/IGI)

There are 42 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
16 O43306 (/TAS) O60266 (/TAS) O60503 (/TAS) O88444 (/TAS) O95622 (/TAS) P30803 (/TAS) P40145 (/TAS) P51828 (/TAS) P51829 (/TAS) P84309 (/TAS)
(6 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
11 O60266 (/IDA) P21932 (/IDA) P26769 (/IDA) P40146 (/IDA) P84309 (/IDA) Q03343 (/IDA) Q04400 (/IDA) Q08462 (/IDA) Q08828 (/IDA) Q29450 (/IDA)
(1 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
10 F1LQT1 (/IDA) O60266 (/IDA) P21932 (/IDA) P26770 (/IDA) P32870 (/IDA) P40146 (/IDA) P51830 (/IDA) P84309 (/IDA) Q03343 (/IDA) Q80TL1 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
10 M9NDN7 (/ISM) M9PBA8 (/ISM) M9PE08 (/ISM) M9PEP2 (/ISM) Q9VK50 (/ISM) Q9VK51 (/ISM) Q9VK52 (/ISM) Q9VK53 (/ISM) Q9VXU0 (/ISM) Q9W038 (/ISM)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
9 O60266 (/ISS) P21932 (/ISS) P30803 (/ISS) P40144 (/ISS) P51830 (/ISS) P84309 (/ISS) P98999 (/ISS) Q04400 (/ISS) Q9DGG6 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
7 O88444 (/ISS) P51830 (/ISS) P98999 (/ISS) Q08462 (/ISS) Q08828 (/ISS) Q80TL1 (/ISS) Q9DGG6 (/ISS)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
6 O60266 (/ISS) O95622 (/ISS) P21932 (/ISS) P30803 (/ISS) P40144 (/ISS) Q04400 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
6 O43306 (/ISS) P26769 (/ISS) Q01341 (/ISS) Q08462 (/ISS) Q80TL1 (/ISS) Q8NFM4 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 O60266 (/IDA) O88444 (/IDA) Q08462 (/IDA) Q8NFM4 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 O95622 (/ISS) P51828 (/ISS) Q8VHH7 (/ISS) Q966F9 (/ISS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 O60503 (/IDA) O95622 (/IDA) P51828 (/IDA) Q8VHH7 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
4 P21932 (/IDA) P26769 (/IDA) Q03343 (/IDA) Q04400 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q80TL1 (/ISO) Q8VHH7 (/ISO) Q91WF3 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 O88444 (/ISO) Q80TL1 (/ISO) Q8VHH7 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 O60503 (/IDA) P19754 (/IDA) P26769 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 P51829 (/ISO) P51830 (/ISO) P84309 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
3 M0R5U4 (/IDA) Q80TL1 (/IDA) Q91WF3 (/IDA)
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
3 O43306 (/ISS) P30804 (/ISS) Q03343 (/ISS)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
3 B3KWA8 (/IDA) C9JRT8 (/IDA) O95622 (/IDA)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
2 P26769 (/IDA) Q91WF3 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 D4A3N4 (/IDA) P21932 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P19754 (/ISS) Q08828 (/ISS)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
2 Q03343 (/IDA) Q04400 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 O60266 (/ISS) Q8VHH7 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 O16880 (/IC) Q19523 (/IC)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 O60266 (/TAS) O60503 (/TAS)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
2 P84309 (/IDA) Q8VHH7 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 P26769 (/ISS) Q08462 (/ISS)
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
2 P26769 (/IDA) P26770 (/IDA)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
1 Q08462 (/ISS)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 P21932 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P51830 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q8VHH7 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P40145 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9V9R3 (/NAS)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 M0R5U4 (/IDA)
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
1 Q01341 (/IDA)
Microvillus membrane GO:0031528
The portion of the plasma membrane surrounding a microvillus.
1 Q03343 (/IDA)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
1 P84309 (/ISO)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 Q08462 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q08828 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 O88444 (/ISO)