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CATH Superfamily 3.30.565.10

Histidine kinase-like ATPase, C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Histidine kinase-like ATPase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 80793: Heat shock protein 90

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Adenosinetriphosphatase. [EC: 3.6.1.3]
ATP + H(2)O = ADP + phosphate.
  • Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39.
  • The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA.
  • Formerly EC 3.6.1.4.
 4 A1Z6L9 B4HTM4 B4LFU3 B4QP43
Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10]
ATP + H(2)O = ADP + phosphate.
  • This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins.
  • They comprise a number of heat-shock-cognate proteins.
  • They are also active in clathrin uncoating and in the oligomerization of actin.
 3 I3RV96 I3RV97 L7QJJ0
DNA topoisomerase (ATP-hydrolyzing). [EC: 5.99.1.3]
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
  • Can introduce negative superhelical turns into double-stranded circular DNA.
  • One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.99.1.2).
 2 B0EKY0 G0R5I6
Histone acetyltransferase. [EC: 2.3.1.48]
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
  • A group of enzymes acetylating histones.
  • Several of the enzymes can also acetylate lysines in other proteins.
 1 A0A061HXP4
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