The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Histidine kinase-like ATPase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 80773: Mitochondrial pyruvate dehydrogenase kinase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
[Pyruvate dehydrogenase (acetyl-transferring)] kinase. [EC: 2.7.11.2]
ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.
  • Has no activating compound but is specific for its substrate.
  • A mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals.
  • Phosphorylation inactivates EC 1.2.4.1.
  • Formerly EC 2.7.1.99.
58 A0A061HV40 A0A084GFR0 A0A0B2P6I1 A0A0B2RL34 A0A0B2SE10 A0A0B2SK88 A0A0B4K7V5 A0A0B4KFG2 A0A0B7FPX4 A0A0D9QYT8
(48 more...)
Transferred entry: 2.7.11.2. [EC: 2.7.1.99]
    10 A0A0B2RL34 A0A0B2SK88 A8I354 A8I371 O82423 O82424 Q6PP98 Q6PP99 Q700B0 Q9JID3
    Histidine kinase. [EC: 2.7.13.3]
    ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
    • This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine).
    • A number of histones can act as acceptor.
    1 A0A060T4Z7
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