The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"SH2 domain
".
FunFam 4364: Non-receptor tyrosine-protein kinase TYK2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
1 | Q9R117 (/ISO) |
|
Growth hormone receptor binding GO:0005131
Interacting selectively and non-covalently with the growth hormone receptor.
|
1 | Q9R117 (/ISO) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | G5EDP9 (/IPI) |
|
Type 1 angiotensin receptor binding GO:0031702
Interacting selectively and non-covalently with a type 1 angiotensin receptor.
|
1 | D3ZD03 (/IPI) |
There are 5 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
|
1 | G5EDP9 (/IGI) |
|
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
|
1 | G5EDP9 (/IMP) |
|
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
|
1 | G5EDP9 (/IMP) |
|
Dauer larval development GO:0040024
The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.
|
1 | G5EDP9 (/IGI) |
|
Dauer larval development GO:0040024
The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.
|
1 | G5EDP9 (/IMP) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q9R117 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9R117 (/ISO) |
|
Phosphatidylinositol 3-kinase complex GO:0005942
A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
|
1 | G5EDP9 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q9R117 (/ISO) |