The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"SH2 domain
".
FunFam 4354: Ras and Rab interactor 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 20 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
9 | A0A087WQ94 (/ISO) A0A087WQM0 (/ISO) A0A087WQS0 (/ISO) A0A087WRU0 (/ISO) A0A1D5RM59 (/ISO) E9Q0S6 (/ISO) Q7TPM8 (/ISO) Q7TSV1 (/ISO) Q9DBT6 (/ISO) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
9 | A0A087WQ94 (/TAS) A0A087WQM0 (/TAS) A0A087WQS0 (/TAS) A0A087WRU0 (/TAS) A0A1D5RM59 (/TAS) E9Q0S6 (/TAS) Q7TPM8 (/TAS) Q7TSV1 (/TAS) Q9DBT6 (/TAS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
7 | Q04205 (/IPI) Q13671 (/IPI) Q63HR2 (/IPI) Q68CZ2 (/IPI) Q8IZW8 (/IPI) Q8TB24 (/IPI) Q9HBL0 (/IPI) |
Rab guanyl-nucleotide exchange factor activity GO:0017112
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
3 | Q13671 (/TAS) Q8TB24 (/TAS) Q8WYP3 (/TAS) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | Q9HBL0 (/IDA) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
1 | Q9VHC3 (/ISS) |
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
|
1 | Q9VRS2 (/IPI) |
Receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | Q8CGB6 (/ISO) |
Ras GTPase binding GO:0017016
Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases.
|
1 | Q921Q7 (/IDA) |
Rab guanyl-nucleotide exchange factor activity GO:0017112
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | Q8TB24 (/IMP) |
Rab guanyl-nucleotide exchange factor activity GO:0017112
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | P59729 (/ISO) |
Rab guanyl-nucleotide exchange factor activity GO:0017112
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | P59729 (/ISS) |
Rab guanyl-nucleotide exchange factor activity GO:0017112
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | Q8WYP3 (/NAS) |
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
|
1 | Q8TB24 (/IDA) |
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
|
1 | P59729 (/ISO) |
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
|
1 | P59729 (/ISS) |
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
1 | Q63HR2 (/IPI) |
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
1 | Q8CGB6 (/ISO) |
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | Q8CGB6 (/ISO) |
GTPase regulator activity GO:0030695
Modulates the rate of GTP hydrolysis by a GTPase.
|
1 | Q8WYP3 (/NAS) |
There are 27 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cell-substrate junction assembly GO:0007044
The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate.
|
9 | A0A087WQ94 (/IMP) A0A087WQM0 (/IMP) A0A087WQS0 (/IMP) A0A087WRU0 (/IMP) A0A1D5RM59 (/IMP) E9Q0S6 (/IMP) Q7TPM8 (/IMP) Q7TSV1 (/IMP) Q9DBT6 (/IMP) |
Fibroblast migration GO:0010761
Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.
|
9 | A0A087WQ94 (/IMP) A0A087WQM0 (/IMP) A0A087WQS0 (/IMP) A0A087WRU0 (/IMP) A0A1D5RM59 (/IMP) E9Q0S6 (/IMP) Q7TPM8 (/IMP) Q7TSV1 (/IMP) Q9DBT6 (/IMP) |
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
|
3 | Q13671 (/TAS) Q8TB24 (/TAS) Q8WYP3 (/TAS) |
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
|
1 | Q8CGB6 (/IMP) |
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
|
1 | Q8TB24 (/NAS) |
Cytoskeletal anchoring at plasma membrane GO:0007016
A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane.
|
1 | Q9VHC3 (/ISS) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
1 | Q13671 (/TAS) |
Small GTPase mediated signal transduction GO:0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
|
1 | Q8WYP3 (/NAS) |
Apposition of dorsal and ventral imaginal disc-derived wing surfaces GO:0007475
The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing.
|
1 | Q9VHC3 (/IMP) |
Imaginal disc-derived wing morphogenesis GO:0007476
The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
|
1 | Q9VHC3 (/IMP) |
Imaginal disc-derived wing morphogenesis GO:0007476
The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
|
1 | Q9VHC3 (/NAS) |
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
|
1 | Q921Q7 (/IMP) |
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
|
1 | Q8IZW8 (/IDA) |
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
|
1 | Q8BZ33 (/ISO) |
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | Q5SSZ5 (/IMP) |
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | Q63HR2 (/IMP) |
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | Q8CGB6 (/ISO) |
Associative learning GO:0008306
Learning by associating a stimulus (the cause) with a particular outcome (the effect).
|
1 | Q921Q7 (/IMP) |
Response to muscle activity GO:0014850
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus.
|
1 | Q8CGB6 (/IMP) |
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
1 | Q5SSZ5 (/IMP) |
Cellular homeostasis GO:0019725
Any process involved in the maintenance of an internal steady state at the level of the cell.
|
1 | Q8CGB6 (/IMP) |
Negative regulation of synaptic plasticity GO:0031914
A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
1 | Q921Q7 (/IMP) |
Collagen metabolic process GO:0032963
The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
|
1 | Q8CGB6 (/IMP) |
Multicellular organism growth GO:0035264
The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
|
1 | Q8CGB6 (/IMP) |
TORC1 signaling GO:0038202
A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components.
|
1 | Q9VRS2 (/IMP) |
Lung alveolus development GO:0048286
The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.
|
1 | Q5SSZ5 (/IMP) |
Multicellular organismal homeostasis GO:0048871
Any process involved in the maintenance of an internal steady state at the level of the multicellular organism.
|
1 | Q8CGB6 (/IMP) |
There are 23 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
18 |
A0A087WQ94 (/IDA)
A0A087WQM0 (/IDA)
A0A087WQS0 (/IDA)
A0A087WRU0 (/IDA)
A0A087WWW7 (/IDA)
A0A1D5RM59 (/IDA)
E9PF55 (/IDA)
E9PGF5 (/IDA)
E9Q0S6 (/IDA)
H0Y4U1 (/IDA)
(8 more) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
12 |
A0A087WQ94 (/ISO)
A0A087WQM0 (/ISO)
A0A087WQS0 (/ISO)
A0A087WRU0 (/ISO)
A0A1D5RM59 (/ISO)
E9Q0S6 (/ISO)
Q5SSZ5 (/ISO)
Q7TPM8 (/ISO)
Q7TSV1 (/ISO)
Q8BZ33 (/ISO)
(2 more) |
Cell-substrate junction GO:0030055
A cell junction that forms a connection between a cell and the extracellular matrix.
|
9 | A0A087WQ94 (/IDA) A0A087WQM0 (/IDA) A0A087WQS0 (/IDA) A0A087WRU0 (/IDA) A0A1D5RM59 (/IDA) E9Q0S6 (/IDA) Q7TPM8 (/IDA) Q7TSV1 (/IDA) Q9DBT6 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | Q13671 (/TAS) Q68CZ2 (/TAS) Q8IZW8 (/TAS) Q8TB24 (/TAS) Q8WYP3 (/TAS) |
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
3 | H2L045 (/IDA) H2L046 (/IDA) P92160 (/IDA) |
M band GO:0031430
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
|
3 | H2L045 (/IDA) H2L046 (/IDA) P92160 (/IDA) |
Striated muscle dense body GO:0055120
A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.
|
3 | H2L045 (/IDA) H2L046 (/IDA) P92160 (/IDA) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
2 | Q8CGB6 (/ISS) Q9VHC3 (/ISS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q13671 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q921Q7 (/ISO) |
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
|
1 | Q8TB24 (/IDA) |
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
|
1 | P59729 (/ISO) |
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
|
1 | P59729 (/ISS) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q68CZ2 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q5SSZ5 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q13671 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q921Q7 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q13671 (/TAS) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
1 | Q921Q7 (/IDA) |
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
|
1 | Q8TB24 (/IDA) |
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
|
1 | P59729 (/ISO) |
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
|
1 | P59729 (/ISS) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
1 | Q921Q7 (/IDA) |