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CATH Superfamily 3.30.505.10

SH2 domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
SH2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4288: Phosphatidylinositol-3,4,5-trisphosphate 5-phospha...

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase. [EC: 3.1.3.86]
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate.
  • This enzyme hydrolyzes phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways.
  • The enzyme also shows activity toward PtdIns(1,3,4,5)P(4).
  • The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects.
  • Formerly EC 3.1.3.n1.
 22 A0A061IG60 A0A061IG60 A0A061IIA1 A0A061IIA1 O15357 O15357 P97573 P97573 Q2I6J0 Q2I6J0
(12 more...)