The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
SH2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4278: Phosphoinositide phospholipase C

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P08487 (/IPI) P10686 (/IPI) P19174 (/IPI) Q62077 (/IPI)
Phosphatidylinositol phospholipase C activity GO:0004435
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
2 P10686 (/TAS) P19174 (/TAS)
Phosphatidylinositol phospholipase C activity GO:0004435
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
1 P19174 (/IDA)
Phosphatidylinositol phospholipase C activity GO:0004435
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
1 Q62077 (/ISO)
Phospholipase C activity GO:0004629
Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.
1 P19174 (/TAS)
Signal transducer activity, downstream of receptor GO:0005057
Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell.
1 P19174 (/NAS)
Insulin receptor binding GO:0005158
Interacting selectively and non-covalently with the insulin receptor.
1 P10686 (/IDA)
Neurotrophin TRKA receptor binding GO:0005168
Interacting selectively and non-covalently with the neurotrophin TRKA receptor.
1 P19174 (/IPI)
Neurotrophin TRKA receptor binding GO:0005168
Interacting selectively and non-covalently with the neurotrophin TRKA receptor.
1 Q62077 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 P19174 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q62077 (/ISO)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
1 Q62077 (/IPI)
Glutamate receptor binding GO:0035254
Interacting selectively and non-covalently with a glutamate receptor.
1 Q62077 (/IPI)
Phosphoprotein binding GO:0051219
Interacting selectively and non-covalently with a phosphorylated protein.
1 P10686 (/IPI)

There are 54 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
5 A0A0R4IMG4 (/IMP) B3DH74 (/IMP) F1QFY8 (/IMP) F1QLX2 (/IMP) Q804J6 (/IMP)
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
5 A0A0R4IMG4 (/IMP) B3DH74 (/IMP) F1QFY8 (/IMP) F1QLX2 (/IMP) Q804J6 (/IMP)
Regulation of heart contraction GO:0008016
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
5 A0A0R4IMG4 (/IMP) B3DH74 (/IMP) F1QFY8 (/IMP) F1QLX2 (/IMP) Q804J6 (/IMP)
Granulocyte differentiation GO:0030851
The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.
5 A0A0R4IMG4 (/IMP) B3DH74 (/IMP) F1QFY8 (/IMP) F1QLX2 (/IMP) Q804J6 (/IMP)
Fin regeneration GO:0031101
The regrowth of fin tissue following its loss or destruction.
5 A0A0R4IMG4 (/IMP) B3DH74 (/IMP) F1QFY8 (/IMP) F1QLX2 (/IMP) Q804J6 (/IMP)
Regulation of angioblast cell migration involved in selective angioblast sprouting GO:0035477
Any process that modulates the frequency, rate or extent of angioblast cell migration involved in selective angioblast sprouting.
5 A0A0R4IMG4 (/IMP) B3DH74 (/IMP) F1QFY8 (/IMP) F1QLX2 (/IMP) Q804J6 (/IMP)
Artery morphogenesis GO:0048844
The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs.
5 A0A0R4IMG4 (/IMP) B3DH74 (/IMP) F1QFY8 (/IMP) F1QLX2 (/IMP) Q804J6 (/IMP)
Hematopoietic stem cell differentiation GO:0060218
The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
5 A0A0R4IMG4 (/IMP) B3DH74 (/IMP) F1QFY8 (/IMP) F1QLX2 (/IMP) Q804J6 (/IMP)
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
3 P08487 (/ISS) P10686 (/ISS) Q62077 (/ISS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2 P10686 (/TAS) P19174 (/TAS)
Border follicle cell migration GO:0007298
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
2 Q24284 (/IGI) Q9VXH3 (/IGI)
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
2 P10686 (/IMP) P19174 (/IMP)
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
2 P08487 (/ISS) Q62077 (/ISS)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
2 Q24284 (/IMP) Q9VXH3 (/IMP)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
2 Q24284 (/IGI) Q9VXH3 (/IGI)
Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096
An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
2 P10686 (/TAS) P19174 (/TAS)
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
2 Q24284 (/IGI) Q9VXH3 (/IGI)
Negative regulation of cell differentiation GO:0045596
Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.
2 Q24284 (/IMP) Q9VXH3 (/IMP)
Activation of MAPKK activity GO:0000186
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
1 P19174 (/TAS)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 Q62077 (/IMP)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 P08487 (/ISS)
Stimulatory C-type lectin receptor signaling pathway GO:0002223
Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.
1 Q62077 (/TAS)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P10686 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 P19174 (/NAS)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 P19174 (/IMP)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 Q62077 (/ISO)
Activation of phospholipase C activity GO:0007202
The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
1 P10686 (/TAS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 P19174 (/TAS)
Protein secretion GO:0009306
The controlled release of proteins from a cell.
1 P10686 (/IMP)
Response to gravity GO:0009629
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus.
1 P10686 (/IEP)
Response to organonitrogen compound GO:0010243
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
1 P10686 (/IEP)
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
1 Q62077 (/ISO)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 P19174 (/IMP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 Q62077 (/ISO)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
1 P19174 (/IMP)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
1 Q62077 (/ISO)
Inositol trisphosphate biosynthetic process GO:0032959
The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached.
1 P10686 (/IMP)
Fc-epsilon receptor signaling pathway GO:0038095
A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
1 P19174 (/TAS)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 P10686 (/IEP)
Response to morphine GO:0043278
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
1 P10686 (/IEP)
Positive regulation of blood vessel endothelial cell migration GO:0043536
Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
1 P19174 (/IDA)
Positive regulation of blood vessel endothelial cell migration GO:0043536
Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
1 Q62077 (/ISO)
Inositol phosphate metabolic process GO:0043647
The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
1 P19174 (/TAS)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 P19174 (/IDA)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 Q62077 (/ISO)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
1 Q62077 (/IDA)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
1 P19174 (/TAS)
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
1 P19174 (/TAS)
Positive regulation of release of sequestered calcium ion into cytosol GO:0051281
Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
1 P19174 (/IMP)
Positive regulation of release of sequestered calcium ion into cytosol GO:0051281
Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
1 Q62077 (/ISO)
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
1 P19174 (/IDA)
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
1 P19174 (/IMP)
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
1 Q62077 (/ISO)
Regulation of store-operated calcium channel activity GO:1901339
Any process that modulates the frequency, rate or extent of store-operated calcium channel activity.
1 P10686 (/IMP)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
3 P08487 (/ISS) P10686 (/ISS) Q62077 (/ISS)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
3 P08487 (/ISS) P10686 (/ISS) Q62077 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P19174 (/TAS) Q62077 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P10686 (/TAS) P19174 (/TAS)
COP9 signalosome GO:0008180
A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
2 P08487 (/ISS) P10686 (/ISS)
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
1 P19174 (/IDA)
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
1 Q62077 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P19174 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q62077 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P10686 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P19174 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q62077 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P19174 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q62077 (/ISO)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 Q62077 (/IDA)
COP9 signalosome GO:0008180
A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
1 P19174 (/IDA)
COP9 signalosome GO:0008180
A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
1 Q62077 (/ISO)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 P19174 (/IDA)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 Q62077 (/ISO)
Cell projection GO:0042995
A prolongation or process extending from a cell, e.g. a flagellum or axon.
1 P19174 (/IDA)
Cell projection GO:0042995
A prolongation or process extending from a cell, e.g. a flagellum or axon.
1 Q62077 (/ISO)