The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
SH2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4268: Tyrosine-protein kinase JAK2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 37 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
5 O19064 (/ISS) O60674 (/ISS) Q5RB23 (/ISS) Q62689 (/ISS) Q75R65 (/ISS)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
5 O19064 (/ISS) Q5RB23 (/ISS) Q62120 (/ISS) Q62689 (/ISS) Q75R65 (/ISS)
Histone kinase activity (H3-Y41 specific) GO:0035401
Catalysis of the transfer of a phosphate group to the tyrosine-41 residue of histone H3.
5 O19064 (/ISS) Q5RB23 (/ISS) Q62120 (/ISS) Q62689 (/ISS) Q75R65 (/ISS)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
5 O19064 (/ISS) Q5RB23 (/ISS) Q62120 (/ISS) Q62689 (/ISS) Q75R65 (/ISS)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
3 O60674 (/TAS) Q62120 (/TAS) Q62689 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 O60674 (/IPI) Q62120 (/IPI) Q62689 (/IPI)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
2 O60674 (/IDA) Q62120 (/IDA)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
2 Q62120 (/IMP) Q62689 (/IMP)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
2 O60674 (/TAS) Q62120 (/TAS)
Growth hormone receptor binding GO:0005131
Interacting selectively and non-covalently with the growth hormone receptor.
2 O60674 (/ISS) Q62120 (/ISS)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 O60674 (/NAS)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 Q62120 (/TAS)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 O60674 (/EXP)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 Q62120 (/ISO)
Ras guanyl-nucleotide exchange factor activity GO:0005088
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 O60674 (/TAS)
Receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 O60674 (/IPI)
Receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q62120 (/ISO)
Growth hormone receptor binding GO:0005131
Interacting selectively and non-covalently with the growth hormone receptor.
1 Q62689 (/IPI)
Interleukin-12 receptor binding GO:0005143
Interacting selectively and non-covalently with the interleukin-12 receptor.
1 Q62120 (/IPI)
Interleukin-12 receptor binding GO:0005143
Interacting selectively and non-covalently with the interleukin-12 receptor.
1 O60674 (/ISS)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 Q62689 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 O60674 (/IDA)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q62120 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q62120 (/ISS)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
1 O60674 (/IDA)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
1 Q62120 (/ISO)
Type 1 angiotensin receptor binding GO:0031702
Interacting selectively and non-covalently with a type 1 angiotensin receptor.
1 Q62689 (/IPI)
Acetylcholine receptor binding GO:0033130
Interacting selectively and non-covalently with an acetylcholine receptor.
1 Q62689 (/IPI)
Histone kinase activity (H3-Y41 specific) GO:0035401
Catalysis of the transfer of a phosphate group to the tyrosine-41 residue of histone H3.
1 O60674 (/IDA)
Histone kinase activity (H3-Y41 specific) GO:0035401
Catalysis of the transfer of a phosphate group to the tyrosine-41 residue of histone H3.
1 Q62120 (/ISO)
SH2 domain binding GO:0042169
Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.
1 O60674 (/IPI)
SH2 domain binding GO:0042169
Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.
1 Q62120 (/ISO)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
1 O60674 (/IDA)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
1 Q62120 (/ISO)
Phosphatidylinositol 3-kinase binding GO:0043548
Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
1 Q62689 (/IPI)
Insulin receptor substrate binding GO:0043560
Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.
1 Q62689 (/IPI)
Peptide hormone receptor binding GO:0051428
Interacting selectively and non-covalently with a receptor for peptide hormones.
1 Q62689 (/IPI)

There are 171 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
5 O19064 (/ISS) O60674 (/ISS) Q5RB23 (/ISS) Q62689 (/ISS) Q75R65 (/ISS)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
5 O19064 (/ISS) O60674 (/ISS) Q5RB23 (/ISS) Q62689 (/ISS) Q75R65 (/ISS)
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
5 O19064 (/ISS) O60674 (/ISS) Q5RB23 (/ISS) Q62689 (/ISS) Q75R65 (/ISS)
Histone H3-Y41 phosphorylation GO:0035409
The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone.
5 O19064 (/ISS) Q5RB23 (/ISS) Q62120 (/ISS) Q62689 (/ISS) Q75R65 (/ISS)
Activation of Janus kinase activity GO:0042976
The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.
5 O19064 (/ISS) O60674 (/ISS) Q5RB23 (/ISS) Q62689 (/ISS) Q75R65 (/ISS)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
5 O19064 (/ISS) O60674 (/ISS) Q5RB23 (/ISS) Q62689 (/ISS) Q75R65 (/ISS)
JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397
The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
5 O19064 (/ISS) O60674 (/ISS) Q5RB23 (/ISS) Q62689 (/ISS) Q75R65 (/ISS)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
4 O19064 (/ISS) O60674 (/ISS) Q5RB23 (/ISS) Q62689 (/ISS)
JAK-STAT cascade GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins.
3 F1QWX8 (/IMP) O93596 (/IMP) Q62120 (/IMP)
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
3 F1QWX8 (/IMP) O93596 (/IMP) Q62120 (/IMP)
JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397
The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
3 O60674 (/TAS) Q62120 (/TAS) Q62689 (/TAS)
JAK-STAT cascade GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins.
2 Q62120 (/IDA) Q62689 (/IDA)
Tyrosine phosphorylation of STAT protein GO:0007260
The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
2 O60674 (/ISS) Q62120 (/ISS)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
2 F1QWX8 (/IMP) O93596 (/IMP)
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
2 F1QWX8 (/IGI) O93596 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 F1QWX8 (/IDA) O93596 (/IDA)
Positive regulation of JAK-STAT cascade GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
2 F1QWX8 (/IDA) O93596 (/IDA)
Blood vessel morphogenesis GO:0048514
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
2 F1QWX8 (/IMP) O93596 (/IMP)
Positive regulation of nitric-oxide synthase biosynthetic process GO:0051770
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme.
2 Q62120 (/IDA) Q62689 (/IDA)
Primitive hemopoiesis GO:0060215
A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells.
2 F1QWX8 (/IMP) O93596 (/IMP)
Regulation of interferon-gamma-mediated signaling pathway GO:0060334
Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor.
2 O60674 (/TAS) Q62120 (/TAS)
JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397
The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
2 Q62120 (/IDA) Q62689 (/IDA)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 O60674 (/TAS)
Activation of MAPKK activity GO:0000186
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
1 Q62689 (/IMP)
Activation of MAPKK activity GO:0000186
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
1 Q62120 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 O60674 (/TAS)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 O60674 (/ISS)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
1 Q62120 (/IDA)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
1 O60674 (/ISS)
Movement of cell or subcellular component GO:0006928
The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.
1 O60674 (/TAS)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 Q62689 (/IMP)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 Q62120 (/ISS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 Q62120 (/IMP)
Enzyme linked receptor protein signaling pathway GO:0007167
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q62120 (/IDA)
Enzyme linked receptor protein signaling pathway GO:0007167
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription.
1 O60674 (/ISS)
G-protein coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 Q62689 (/IMP)
G-protein coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 Q62120 (/ISS)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
1 Q62689 (/IMP)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
1 Q62120 (/ISS)
JAK-STAT cascade GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins.
1 O60674 (/TAS)
Tyrosine phosphorylation of STAT protein GO:0007260
The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
1 Q62120 (/IDA)
Tyrosine phosphorylation of STAT protein GO:0007260
The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
1 Q62120 (/IMP)
STAT protein import into nucleus GO:0007262
The directed movement of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases.
1 Q62120 (/IDA)
STAT protein import into nucleus GO:0007262
The directed movement of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases.
1 O60674 (/ISS)
Mesoderm development GO:0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
1 O60674 (/TAS)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
1 O60674 (/TAS)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q62689 (/IMP)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q62120 (/ISS)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q62120 (/IMP)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 O60674 (/ISS)
Intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.
1 Q62689 (/IMP)
Intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.
1 Q62120 (/ISS)
Hormone-mediated signaling pathway GO:0009755
A series of molecular signals mediated by the detection of a hormone.
1 Q62689 (/IDA)
Hormone-mediated signaling pathway GO:0009755
A series of molecular signals mediated by the detection of a hormone.
1 Q62120 (/ISS)
Negative regulation of cardiac muscle cell apoptotic process GO:0010667
Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
1 Q62689 (/IMP)
Positive regulation of cell-substrate adhesion GO:0010811
Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
1 O60674 (/IDA)
Positive regulation of cell-substrate adhesion GO:0010811
Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
1 Q62120 (/ISO)
Positive regulation of cell-substrate adhesion GO:0010811
Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
1 Q62120 (/ISS)
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
1 Q62120 (/IMP)
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
1 O60674 (/ISS)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
1 Q62120 (/IDA)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
1 O60674 (/ISS)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 O60674 (/IDA)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q62120 (/IMP)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q62120 (/ISO)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q62120 (/TAS)
Negative regulation of cell-cell adhesion GO:0022408
Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.
1 Q62689 (/IMP)
Negative regulation of cell-cell adhesion GO:0022408
Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.
1 Q62120 (/ISS)
Actin filament polymerization GO:0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
1 O60674 (/NAS)
Lymphocyte differentiation GO:0030098
The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
1 B0V237 (/IMP)
Myeloid cell differentiation GO:0030099
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
1 Q62120 (/IMP)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
1 Q62120 (/IMP)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
1 O60674 (/ISS)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 Q62689 (/IMP)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 Q62120 (/ISS)
Axon regeneration GO:0031103
The regrowth of axons following their loss or damage.
1 Q62689 (/IMP)
Axon regeneration GO:0031103
The regrowth of axons following their loss or damage.
1 Q62120 (/ISS)
Mineralocorticoid receptor signaling pathway GO:0031959
Any series of molecular signals generated as a consequence of a mineralocorticoid binding to its receptor.
1 Q62689 (/IMP)
Mineralocorticoid receptor signaling pathway GO:0031959
Any series of molecular signals generated as a consequence of a mineralocorticoid binding to its receptor.
1 Q62120 (/ISS)
Positive regulation of insulin secretion GO:0032024
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
1 Q62689 (/IMP)
Positive regulation of insulin secretion GO:0032024
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
1 Q62120 (/ISS)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q62120 (/IDA)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 O60674 (/ISS)
Positive regulation of phosphoprotein phosphatase activity GO:0032516
Any process that activates or increases the activity of a phosphoprotein phosphatase.
1 Q62689 (/IMP)
Positive regulation of phosphoprotein phosphatase activity GO:0032516
Any process that activates or increases the activity of a phosphoprotein phosphatase.
1 Q62120 (/ISS)
Positive regulation of interleukin-1 beta production GO:0032731
Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production.
1 Q62689 (/IMP)
Positive regulation of interleukin-1 beta production GO:0032731
Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production.
1 Q62120 (/ISS)
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
1 Q62120 (/IDA)
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
1 O60674 (/ISS)
T cell differentiation in thymus GO:0033077
The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.
1 B0V237 (/IMP)
Positive regulation of protein import into nucleus, translocation GO:0033160
Any process that activates or increases the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane.
1 Q62689 (/IMP)
Positive regulation of protein import into nucleus, translocation GO:0033160
Any process that activates or increases the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane.
1 Q62120 (/ISS)
Response to hydroperoxide GO:0033194
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.
1 Q62689 (/IMP)
Response to hydroperoxide GO:0033194
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.
1 Q62120 (/ISS)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 O60674 (/IDA)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q62120 (/ISO)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q62120 (/ISS)
Host programmed cell death induced by symbiont GO:0034050
Cell death in a host resulting from activation of host endogenous cellular processes after direct or indirect interaction with a symbiont (defined as the smaller of two, or more, organisms engaged in symbiosis, a close interaction encompassing mutualism through parasitism). An example of direct interaction is contact with penetrating hyphae of a fungus; an example of indirect interaction is encountering symbiont-secreted molecules.
1 Q62120 (/IDA)
Response to tumor necrosis factor GO:0034612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 O60674 (/IDA)
Response to tumor necrosis factor GO:0034612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 Q62120 (/ISO)
Response to tumor necrosis factor GO:0034612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 Q62120 (/ISS)
Post-embryonic hemopoiesis GO:0035166
The stages of blood cell formation that take place after completion of embryonic development.
1 Q62120 (/IMP)
Histone H3-Y41 phosphorylation GO:0035409
The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone.
1 O60674 (/IDA)
Histone H3-Y41 phosphorylation GO:0035409
The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone.
1 Q62120 (/ISO)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 Q62120 (/IDA)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 O60674 (/ISS)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 O60674 (/TAS)
Interleukin-12-mediated signaling pathway GO:0035722
A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 O60674 (/IDA)
Interleukin-12-mediated signaling pathway GO:0035722
A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q62120 (/ISO)
Interleukin-12-mediated signaling pathway GO:0035722
A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q62120 (/ISS)
Cellular response to interleukin-3 GO:0036016
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus.
1 Q62120 (/IDA)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
1 Q62120 (/IDA)
Activation of Janus kinase activity GO:0042976
The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.
1 Q62120 (/IDA)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q62689 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q62120 (/IDA)
Positive regulation of DNA binding GO:0043388
Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
1 Q62689 (/IMP)
Positive regulation of DNA binding GO:0043388
Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
1 Q62120 (/ISS)
Negative regulation of DNA binding GO:0043392
Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
1 Q62120 (/IDA)
Negative regulation of DNA binding GO:0043392
Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
1 O60674 (/ISS)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
1 Q62689 (/IMP)
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 Q62689 (/IMP)
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 Q62120 (/ISS)
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
1 Q62689 (/IMP)
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
1 Q62120 (/ISS)
Negative regulation of heart contraction GO:0045822
Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.
1 Q62689 (/IMP)
Negative regulation of heart contraction GO:0045822
Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.
1 Q62120 (/ISS)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q62120 (/IGI)
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
1 O60674 (/IDA)
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
1 Q62120 (/ISO)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 Q62120 (/IDA)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 Q62689 (/IMP)
Platelet-derived growth factor receptor signaling pathway GO:0048008
The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
1 Q62689 (/IMP)
Platelet-derived growth factor receptor signaling pathway GO:0048008
The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
1 Q62120 (/ISS)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
1 O60674 (/IDA)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
1 Q62120 (/ISO)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
1 Q62120 (/ISS)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
1 Q62689 (/IMP)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
1 Q62120 (/ISS)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
1 Q62120 (/IMP)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
1 O60674 (/ISS)
Positive regulation of cell activation GO:0050867
Any process that activates or increases the frequency, rate or extent of activation.
1 Q62689 (/IMP)
Positive regulation of cell activation GO:0050867
Any process that activates or increases the frequency, rate or extent of activation.
1 Q62120 (/ISS)
Positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q62689 (/IMP)
Positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q62120 (/ISS)
Positive regulation of nitric-oxide synthase biosynthetic process GO:0051770
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme.
1 O60674 (/ISS)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
1 Q62689 (/IDA)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
1 Q62120 (/ISS)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
1 O60674 (/TAS)
Growth hormone receptor signaling pathway GO:0060396
The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand.
1 O60674 (/IDA)
Growth hormone receptor signaling pathway GO:0060396
The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand.
1 Q62120 (/ISO)
Growth hormone receptor signaling pathway GO:0060396
The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand.
1 Q62120 (/ISS)
JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397
The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
1 Q62120 (/IMP)
Positive regulation of growth hormone receptor signaling pathway GO:0060399
Any process that increases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand.
1 Q62120 (/IMP)
Positive regulation of growth hormone receptor signaling pathway GO:0060399
Any process that increases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand.
1 O60674 (/ISS)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 Q62689 (/IMP)
Mammary gland epithelium development GO:0061180
The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
1 Q62120 (/IMP)
Mammary gland epithelium development GO:0061180
The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
1 O60674 (/ISS)
Response to interleukin-12 GO:0070671
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus.
1 O60674 (/IDA)
Response to interleukin-12 GO:0070671
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus.
1 Q62120 (/ISO)
Response to interleukin-12 GO:0070671
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus.
1 Q62120 (/ISS)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q62120 (/IDA)
Cellular response to dexamethasone stimulus GO:0071549
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
1 Q62120 (/IDA)
Response to granulocyte macrophage colony-stimulating factor GO:0097012
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus.
1 Q62120 (/NAS)
Extrinsic apoptotic signaling pathway GO:0097191
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
1 Q62120 (/IDA)
Extrinsic apoptotic signaling pathway GO:0097191
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
1 O60674 (/ISS)
Activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296
Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway.
1 Q62120 (/IDA)
Activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296
Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway.
1 O60674 (/ISS)
Positive regulation of growth factor dependent skeletal muscle satellite cell proliferation GO:1902728
Any process that activates or increases the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta.
1 Q62689 (/IMP)
Positive regulation of epithelial cell apoptotic process GO:1904037
Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process.
1 Q62689 (/IMP)
Positive regulation of vascular smooth muscle cell proliferation GO:1904707
Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation.
1 Q62689 (/IMP)
Positive regulation of apoptotic signaling pathway GO:2001235
Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.
1 Q62120 (/IMP)

There are 23 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 O19064 (/ISS) Q5RB23 (/ISS) Q62120 (/ISS) Q62689 (/ISS) Q75R65 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 G1TCI4 (/IDA) O60674 (/IDA) Q62120 (/IDA) Q62689 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 O60674 (/TAS) Q62120 (/TAS) Q62689 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 O60674 (/IDA) Q62689 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q62120 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 O60674 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q62120 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 O60674 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q62120 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q62120 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q62120 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q62689 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O60674 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q62120 (/ISO)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
1 Q62120 (/IDA)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
1 O60674 (/ISS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 O60674 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 Q62120 (/ISO)
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
1 Q62689 (/IDA)
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
1 Q62120 (/ISS)
Endosome lumen GO:0031904
The volume enclosed by the membrane of an endosome.
1 O60674 (/TAS)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 Q62120 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 O60674 (/ISS)