The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
SH2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4167: SHC-transforming protein 1 isoform 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 22 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P29353 (/IPI) P98083 (/IPI) Q5M824 (/IPI)
Phosphotyrosine binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
2 P29353 (/IPI) Q5M824 (/IPI)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
2 P98083 (/IPI) Q5M824 (/IPI)
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
2 P29353 (/IPI) P98083 (/IPI)
Phosphotyrosine binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
1 P98083 (/ISO)
Transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068
The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way.
1 P29353 (/TAS)
Ras guanyl-nucleotide exchange factor activity GO:0005088
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 P29353 (/TAS)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
1 Q5M824 (/IPI)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
1 P29353 (/ISS)
Insulin receptor binding GO:0005158
Interacting selectively and non-covalently with the insulin receptor.
1 P29353 (/IPI)
Insulin receptor binding GO:0005158
Interacting selectively and non-covalently with the insulin receptor.
1 P98083 (/ISO)
Insulin-like growth factor receptor binding GO:0005159
Interacting selectively and non-covalently with the insulin-like growth factor receptor.
1 P29353 (/IPI)
Insulin-like growth factor receptor binding GO:0005159
Interacting selectively and non-covalently with the insulin-like growth factor receptor.
1 P98083 (/ISO)
Neurotrophin TRKA receptor binding GO:0005168
Interacting selectively and non-covalently with the neurotrophin TRKA receptor.
1 P29353 (/IPI)
Neurotrophin TRKA receptor binding GO:0005168
Interacting selectively and non-covalently with the neurotrophin TRKA receptor.
1 P98083 (/ISO)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
1 P29353 (/TAS)
Protein complex binding GO:0032403
Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q5M824 (/IPI)
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
1 P98083 (/ISO)
Epidermal growth factor binding GO:0048408
Interacting selectively and non-covalently with epidermal growth factor.
1 P98083 (/IPI)
Phosphoprotein binding GO:0051219
Interacting selectively and non-covalently with a phosphorylated protein.
1 Q5M824 (/IPI)
Protein phosphatase 2A binding GO:0051721
Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
1 Q5M824 (/IDA)
Protein phosphatase 2A binding GO:0051721
Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
1 Q5M824 (/IPI)

There are 60 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to growth factor stimulus GO:0071363
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
4 P98083 (/ISS) Q0IIE2 (/ISS) Q5M824 (/ISS) Q5R7W7 (/ISS)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
3 P29353 (/IMP) P98083 (/IMP) Q5M824 (/IMP)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
3 E7F3T0 (/IMP) E9QCZ8 (/IMP) P98083 (/IMP)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 P29353 (/IDA)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 P98083 (/ISO)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 P98083 (/ISS)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 P29353 (/TAS)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
1 P29353 (/IDA)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
1 P98083 (/ISO)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
1 P98083 (/ISS)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q5M824 (/IEP)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 P98083 (/IDA)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 P29353 (/TAS)
Regulation of epidermal growth factor-activated receptor activity GO:0007176
Any process that modulates the frequency, rate or extent of EGF-activated receptor activity.
1 P29353 (/TAS)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
1 P29353 (/TAS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 P29353 (/TAS)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 P98083 (/IMP)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 Q5M824 (/IPI)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P29353 (/NAS)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P29353 (/TAS)
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
1 Q5M824 (/IDA)
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
1 Q5M824 (/IMP)
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
1 P29353 (/ISS)
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
1 P29353 (/TAS)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
1 Q5M824 (/IEP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 Q5M824 (/IEP)
Single organismal cell-cell adhesion GO:0016337
The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism.
1 P98083 (/IMP)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q5M824 (/IMP)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 Q5M824 (/IMP)
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
1 Q5M824 (/IEP)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q5M824 (/IMP)
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
1 P98083 (/IMP)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 Q5M824 (/IEP)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 Q5M824 (/IEP)
Response to nicotine GO:0035094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.
1 Q5M824 (/IEP)
IRE1-mediated unfolded protein response GO:0036498
A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
1 P29353 (/TAS)
Fc-epsilon receptor signaling pathway GO:0038095
A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
1 P29353 (/TAS)
ERBB2 signaling pathway GO:0038128
A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair.
1 P29353 (/TAS)
Regulation of cell proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
1 P98083 (/IMP)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 Q5M824 (/IEP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 P29353 (/IMP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 P98083 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P29353 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P98083 (/ISO)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
1 P29353 (/IMP)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
1 P98083 (/ISO)
Positive regulation of DNA replication GO:0045740
Any process that activates or increases the frequency, rate or extent of DNA replication.
1 Q5M824 (/IMP)
Positive regulation of DNA replication GO:0045740
Any process that activates or increases the frequency, rate or extent of DNA replication.
1 P29353 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 P29353 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 P98083 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 P29353 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 P98083 (/ISO)
Positive regulation of vasoconstriction GO:0045907
Any process that activates or increases the frequency, rate or extent of vasoconstriction.
1 Q5M824 (/IMP)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
1 Q5M824 (/IMP)
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
1 P29353 (/TAS)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 Q5M824 (/IEP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 P29353 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 P98083 (/ISO)
Cellular response to growth factor stimulus GO:0071363
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
1 P29353 (/IDA)
Cellular response to growth factor stimulus GO:0071363
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
1 P98083 (/ISO)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P29353 (/TAS) P98083 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P29353 (/IDA) Q5M824 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q5M824 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q5M824 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P98083 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P98083 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P29353 (/TAS)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
1 Q5M824 (/IDA)
Shc-EGFR complex GO:0070435
A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway.
1 Q5M824 (/IDA)
Shc-EGFR complex GO:0070435
A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway.
1 P29353 (/ISS)