The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 30168: cGMP-specific 3',5'-cyclic phosphodiesterase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
3',5'-cyclic-GMP phosphodiesterase activity GO:0047555
Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.
2 O54735 (/TAS) O76074 (/TAS)
Cyclic-nucleotide phosphodiesterase activity GO:0004112
Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate.
1 Q8CG03 (/IDA)
Cyclic-nucleotide phosphodiesterase activity GO:0004112
Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate.
1 Q28156 (/ISS)
3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.
1 Q8CG03 (/IMP)
3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.
1 O76074 (/NAS)
CGMP binding GO:0030553
Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).
1 Q8CG03 (/IDA)
CGMP binding GO:0030553
Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).
1 Q28156 (/ISS)
CGMP binding GO:0030553
Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).
1 O76074 (/TAS)
3',5'-cyclic-GMP phosphodiesterase activity GO:0047555
Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.
1 O54735 (/IDA)
3',5'-cyclic-GMP phosphodiesterase activity GO:0047555
Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.
1 Q28156 (/ISS)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
CGMP catabolic process GO:0046069
The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate.
2 O76074 (/IDA) Q8CG03 (/IDA)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 O54735 (/IEP)
Regulation of the force of heart contraction GO:0002026
Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
1 O54735 (/IMP)
Positive regulation of chronic inflammatory response GO:0002678
Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response.
1 O54735 (/IMP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 O54735 (/IEP)
Short-term memory GO:0007614
The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.
1 O54735 (/IMP)
Positive regulation of cardiac muscle hypertrophy GO:0010613
Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
1 Q8CG03 (/IMP)
Regulation of cGMP metabolic process GO:0030823
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP.
1 Q8CG03 (/IGI)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 O54735 (/IEP)
Response to testosterone GO:0033574
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
1 O54735 (/IEP)
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
1 Q8CG03 (/IMP)
Vasodilation GO:0042311
An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure.
1 O54735 (/IEP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 O54735 (/IMP)
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
1 Q8CG03 (/IMP)
Positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745
Any process that activates or increases the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity.
1 Q8CG03 (/IC)
Positive regulation of vasoconstriction GO:0045907
Any process that activates or increases the frequency, rate or extent of vasoconstriction.
1 O54735 (/IMP)
CGMP metabolic process GO:0046068
The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate.
1 Q8CG03 (/IMP)
CGMP catabolic process GO:0046069
The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate.
1 Q8CG03 (/ISO)
CGMP catabolic process GO:0046069
The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate.
1 Q28156 (/ISS)
Negative regulation of cardiac muscle contraction GO:0055118
Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction.
1 Q8CG03 (/IMP)
Relaxation of cardiac muscle GO:0055119
The process in which the extent of cardiac muscle contraction is reduced.
1 Q8CG03 (/IMP)
Positive regulation of oocyte development GO:0060282
Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
1 Q8CG03 (/IGI)
Positive regulation of oocyte development GO:0060282
Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
1 Q8CG03 (/IMP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O54735 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O76074 (/TAS)