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CATH Superfamily 3.30.450.40

GAF domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: GAF domain

This entry represents the GAF domain and domains sharing protein structural similarity, such as the C-terminal domain of the transcription regulator IclR, the C-terminal domain of the heat-inducible transcription repressor HrcA, and the phytochrome chromophore attachment domain. The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes PMID:9433123,PMID:20004158. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain PMID:11032796.

PMID:9433123 PMID:20004158 PMID:11032796

GO Diversity

Unique GO annotations
324 Unique GO terms

EC Diversity

Unique EC annotations
89 Unique EC terms

Species Diversity

Unique species annotations
18811 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 306
Domain clusters (>95% seq id): 81
Domain clusters (>35% seq id): 53
Unique PDBs: 152
Alignments
Structural Clusters (5A): 6
Structural Clusters (9A): 3
FunFam Clusters: 96
Function
Unique EC: 89
Unique GO: 324
Taxonomy
Unique Species: 18811