The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 92735: Putative KHG/KDPG aldolase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-dehydro-3-deoxy-phosphogluconate aldolase. [EC: 4.1.2.14]
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.
  • The enzyme shows no activity with 2-dehydro-3-deoxy-6-phosphate-D- galactonate (cf. EC 4.1.2.55).
  • Also acts on 2-oxobutanoate.
6 A0A0H3PC05 A0A0Y7JWY8 A0A0Y7NSJ5 A0A112WNJ0 P44480 Q4QPJ7
4-hydroxy-2-oxoglutarate aldolase. [EC: 4.1.3.16]
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
  • The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate.
  • Formerly EC 4.1.2.1 and EC 4.1.2.31.
2 P44480 Q4QPJ7
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