The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 92591: Bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-d...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-dehydro-3-deoxy-phosphogluconate aldolase. [EC: 4.1.2.14]
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.
  • The enzyme shows no activity with 2-dehydro-3-deoxy-6-phosphate-D- galactonate (cf. EC 4.1.2.55).
  • Also acts on 2-oxobutanoate.
7 A0A0A7X4Z8 A0A0H3BKR8 A0A1L7DEX8 F7XRE1 H6KUQ1 O83578 R9UW58
4-hydroxy-2-oxoglutarate aldolase. [EC: 4.1.3.16]
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
  • The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate.
  • Formerly EC 4.1.2.1 and EC 4.1.2.31.
7 A0A0A7X4Z8 A0A0H3BKR8 A0A1L7DEX8 F7XRE1 H6KUQ1 O83578 R9UW58
CATH-Gene3D is a Global Biodata Core Resource Learn more...