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CATH Superfamily 3.20.20.70

Aldolase class I

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 42266: Fructose-bisphosphate aldolase/6-deoxy-5-ketofruct...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Fructose-bisphosphate aldolase. [EC: 4.1.2.13]
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
  • Also acts on (3S,4R)-ketose 1-phosphates.
  • The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc.
  • Formerly EC 4.1.2.7.
 4 C7P7E5 C9RF81 D3S781 Q58980
6-deoxy-5-ketofructose 1-phosphate synthase. [EC: 2.2.1.11]
(1) 2-oxopropanal + D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate. (2) 2-oxopropanal + D-fructose 1-phosphate = D-glyceraldehyde + 1-deoxy- D-threo-hexo-2,5-diulose 6-phosphate.
  • The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
  • The enzyme can also catalyze the reaction of EC 4.1.2.13.
 1 Q58980