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CATH Superfamily 3.20.20.70

Aldolase class I

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 120939: Glucose-6-phosphate isomerase / transaldolase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Transaldolase. [EC: 2.2.1.2]
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.
    		 6700 A0A010PME8 A0A010PME8 A0A011T478 A0A011T478 A0A013XWA4 A0A013XWA4 A0A014LSG1 A0A014LSG1 A0A021VS52 A0A021VS52
    (6690 more...)
    Glucose-6-phosphate isomerase. [EC: 5.3.1.9]
    D-glucose 6-phosphate = D-fructose 6-phosphate.
    • Also catalyzes the anomerization of D-glucose 6-phosphate.
    		 32 A0A0D7E5B0 A0A0D7E5B0 A0A0J6SPZ6 A0A0J6SPZ6 A0A0M9B6S6 A0A0M9B6S6 A0A149T3E9 A0A149T3E9 A0A160TI71 A0A160TI71
    (22 more...)
    Ribonuclease E. [EC: 3.1.26.12]
    Endonucleolytic cleavage of single-stranded RNA in A- and U-rich regions.
    • RNase E is a bacterial ribonuclease that plays a role in the processing of ribosomal RNA (9S to 5S rRNA), the chemical degradation of bulk cellular RNA, the decay of specific regulatory, messenger and structural RNAs and the control of plasmid DNA replication.
    • The enzyme binds to monophosphorylated 5' ends of substrates but exhibits sequential cleavages in the 3' to 5' direction.
    • 2'-O-methyl nucleotide substitutions at RNase E binding sites do not prevent binding but do prevent cleavage of non-modified target sequences 5' to that locus.
    • In Escherichia coli, the enzyme is found in the RNA degradosome.
    • The C-terminal half of the protein contains binding sites for the three other major degradosomal components, the DEAD-box RNA helicase Rh1B, EC 4.1.1.11 and EC 2.7.7.8.
    • Formerly EC 3.1.26.n1.
    		 8 A0A1C3H317 A0A1C3H317 A5EW86 A5EW86 C8N8A8 C8N8A8 G9ZFU9 G9ZFU9
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