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CATH Superfamily 3.20.20.70

Aldolase class I

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 120927: 7-carboxy-7-deazaguanine synthase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
7-carboxy-7-deazaguanine synthase. [EC: 4.3.99.3]
6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH(3).
  • The enzyme is a member of the superfamily of S-adenosyl-L-methionine- dependent radical (radical AdoMet) enzymes.
  • Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule.
  • The S-adenosyl-L-methionine is catalytic as it is regenerated at the end of the reaction.
  • The reaction is part of the biosynthesis pathway of queuosine.
 190 A0A011MKT3 A0A017QLK6 A0A063CYB2 A0A063ZP59 A0A084EXS2 A0A099W8A5 A0A099WDD7 A0A0A2XCK4 A0A0A2Y382 A0A0A2YC72
(180 more...)