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CATH Superfamily 3.20.20.70

Aldolase class I

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 120872: 4-hydroxy-tetrahydrodipicolinate synthase 1, chlor...

There are 17 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
4-hydroxy-tetrahydrodipicolinate synthase. [EC: 4.3.3.7]
Pyruvate + L-aspartate-4-semialdehyde = (4S)-4-hydroxy-2,3,4,5- tetrahydro-(2S)-dipicolinate + H(2)O.
  • Formerly EC 4.2.1.52.
 33162 A0A009EVQ2 A0A009EVQ2 A0A009H5V1 A0A009H5V1 A0A009HEY2 A0A009HEY2 A0A009I0V8 A0A009I0V8 A0A009IRW5 A0A009IRW5
(33152 more...)
5-dehydro-4-deoxyglucarate dehydratase. [EC: 4.2.1.41]
5-dehydro-4-deoxy-D-glucarate = 2,5-dioxopentanoate + H(2)O + CO(2).
    		 3624 A0A009GHG7 A0A009GHG7 A0A009H369 A0A009H369 A0A009HNN8 A0A009HNN8 A0A009HSY2 A0A009HSY2 A0A009JQL1 A0A009JQL1
    (3614 more...)
    N-acetylneuraminate lyase. [EC: 4.1.3.3]
    N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate.
    • Also acts on N-glycoloylneuraminate, and on O-acetylated sialic acids, other than 4-O-acetylated derivatives.
    		 3154 A0A011P8Z0 A0A011P8Z0 A0A015S1J8 A0A015S1J8 A0A015T2B1 A0A015T2B1 A0A015UQF8 A0A015UQF8 A0A015VFB2 A0A015VFB2
    (3144 more...)
    Transferred entry: 4.3.3.7. [EC: 4.2.1.52]
      		382 A0A061YRY4 A0A061YRY4 A0A067AM15 A0A067AM15 A0A077M6V4 A0A077M6V4 A0A077M737 A0A077M737 A0A095LBW5 A0A095LBW5
      (372 more...)
      1-pyrroline-4-hydroxy-2-carboxylate deaminase. [EC: 3.5.4.22]
      1-pyrroline-4-hydroxy-2-carboxylate + H(2)O = 2,5-dioxopentanoate + NH(3).
        		 108 A0A069PFC0 A0A069PFC0 A0A087PQV1 A0A087PQV1 A0A090TAC3 A0A090TAC3 A0A099XWP5 A0A099XWP5 A0A0A1F827 A0A0A1F827
        (98 more...)
        Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase. [EC: 4.1.2.45]
        (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H(2)O = salicylaldehyde + pyruvate.
        • This enzyme is involved in naphthalene degradation.
        • The enzyme catalyzes a retro-aldol reaction in vitro, and it accepts a broad range of aldehydes and 4-substituted 2-oxobut-3-enoates as substrates.
        		 32 A0A010RPC2 A0A010RPC2 A0A0J5Q5D8 A0A0J5Q5D8 A0A0M4FDT0 A0A0M4FDT0 C3KFM9 C3KFM9 G9G7J1 G9G7J1
        (22 more...)
        4-hydroxy-2-oxoglutarate aldolase. [EC: 4.1.3.16]
        4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
        • The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate.
        • Formerly EC 4.1.2.1 and EC 4.1.2.31.
        		 24 A0A084G494 A0A084G494 A0A0F4YZY3 A0A0F4YZY3 A0A0F8CTK8 A0A0F8CTK8 A0A0M8K8N1 A0A0M8K8N1 P0CL20 P0CL20
        (14 more...)
        2-dehydro-3-deoxy-phosphogluconate aldolase. [EC: 4.1.2.14]
        2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.
        • The enzyme shows no activity with 2-dehydro-3-deoxy-6-phosphate-D- galactonate (cf. EC 4.1.2.55).
        • Also acts on 2-oxobutanoate.
        		 20 A0A088E4S2 A0A088E4S2 A0A0U5CW98 A0A0U5CW98 A0A151AFC9 A0A151AFC9 A4YGA2 A4YGA2 F7PKW4 F7PKW4
        (10 more...)
        2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase. [EC: 4.1.2.55]
        (1) 2-dehydro-3-deoxy-6-phospho-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate. (2) 2-dehydro-3-deoxy-6-phospho-D-galactonate = pyruvate + D-glyceraldehyde 3-phosphate.
        • In the archaeon Sulfolobus solfataricus the enzyme is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway.
        • It utilizes 2-dehydro-3-deoxy-6-phosphate-D-gluconate and 2-dehydro- 3-deoxy-6-phosphate-D-galactonate with similar catalytic efficiency.
        • In vitro the enzyme can also catalyze the cleavage of the non- phosphorylated forms 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3- deoxy-D-galactonate with much lower catalytic efficiency.
        • Cf. EC 4.1.2.21 and EC 4.1.2.14.
        		 18 A0A0E3GT72 A0A0E3GT72 A0A0U3GTV7 A0A0U3GTV7 A0A157T6F6 A0A157T6F6 D0KR10 D0KR10 F9VPG1 F9VPG1
        (8 more...)
        4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase. [EC: 4.1.2.34]
        (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(2)O = 2-formylbenzoate + pyruvate.
        • Involved, with EC 1.13.11.38, in the metabolism of phenanthrene in bacteria.
        		 12 A0A0D5VCW2 A0A0D5VCW2 A0A0M5LIT0 A0A0M5LIT0 A0A158GIA0 A0A158GIA0 C7DQZ6 C7DQZ6 Q79EM8 Q79EM8
        (2 more...)
        L-threo-3-deoxy-hexylosonate aldolase. [EC: 4.1.2.54]
        2-dehydro-3-deoxy-L-galactonate = pyruvate + L-glyceraldehyde.
        • The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina).
        		 10 A0A024SFW9 A0A024SFW9 A6Y9S5 A6Y9S5 A8DRH7 A8DRH7 G0RHH4 G0RHH4 G3Y3P3 G3Y3P3
        2-dehydro-3-deoxy-6-phosphogalactonate aldolase. [EC: 4.1.2.21]
        2-dehydro-3-deoxy-6-phospho-D-galactonate = pyruvate + D-glyceraldehyde 3-phosphate.
        • The enzyme catalyzes the last reaction in a D-galactose degradation pathway.
        • Cf. EC 4.1.2.55.
        		 10 A0A088E4S2 A0A088E4S2 A0A151AFC9 A0A151AFC9 A4WKN2 A4WKN2 A4YGA2 A4YGA2 Q6KZI8 Q6KZI8
        2-dehydro-3-deoxy-D-gluconate aldolase. [EC: 4.1.2.51]
        2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde.
        • The enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway.
        • In the direction of aldol synthesis the enzyme catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D- galactonate at a similar ratio.
        • It shows no activity with 2-dehydro-3-deoxy-D-gluconate 6-phosphate.
        • Cf. EC 4.1.2.14.
        		 6 A0A151AFC9 A0A151AFC9 Q6KZI8 Q6KZI8 Q704D1 Q704D1
        N-acylglucosamine-6-phosphate 2-epimerase. [EC: 5.1.3.9]
        N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate.
          		 2 F4MZ09 F4MZ09
          Quinolinate synthase. [EC: 2.5.1.72]
          Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H(2)O + phosphate.
          • Quinolinate synthase catalyzes the second step in the de novo biosynthesis of NAD(+) from aspartate in some bacteria, with EC 1.4.3.16 catalyzing the first step and EC 2.4.2.19 the third step.
          • In Escherichia coli, two of the residues that are involved in the [4Fe-4S] cluster binding appear to undergo reversible disulfide-bond formation that regulates the activity of the enzyme.
          		 2 K4L413 K4L413
          N(6)-L-threonylcarbamoyladenine synthase. [EC: 2.3.1.234]
          L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L- threonylcarbamoyladenine(37) in tRNA.
          • The enzyme is involved in the synthesis of N(6)- threonylcarbamoyladenosine(37) in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNA(Ile), tRNA(Thr), tRNA(Asn), tRNA(Lys), tRNA(Ser) and tRNA(Arg).
          • Formerly EC 2.6.99.4.
          		 2 A0A1A9VJQ4 A0A1A9VJQ4
          L-rhamnonate dehydratase. [EC: 4.2.1.90]
          L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H(2)O.
            		 2 G0R5Q2 G0R5Q2
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