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CATH Superfamily 3.20.20.70

Aldolase class I

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 120787: Dihydroorotate dehydrogenase, catalytic subunit

There are 9 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Dihydrouracil dehydrogenase (NAD(+)). [EC: 1.3.1.1]
(1) 5,6-dihydrouracil + NAD(+) = uracil + NADH. (2) 5,6-dihydrothymine + NAD(+) = thymine + NADH.
  • The enzyme was originally discovered in the uracil-fermenting bacterium, Clostridium uracilicum, which utilizes uracil and thymine as nitrogen and carbon sources for growth.
  • Since then the enzyme was found in additional organisms including Alcaligenes eutrophus, Pseudomonas strains and Escherichia coli.
 1980 A0A010SRG7 A0A010SRG7 A0A010ZND9 A0A010ZND9 A0A011SR03 A0A011SR03 A0A011T6S7 A0A011T6S7 A0A015KKK9 A0A015KKK9
(1970 more...)
Dihydropyrimidine dehydrogenase (NADP(+)). [EC: 1.3.1.2]
5,6-dihydrouracil + NADP(+) = uracil + NADPH.
  • Also acts on dihydrothymine.
 632 A0A010ZND9 A0A010ZND9 A0A017H8W3 A0A017H8W3 A0A017HUM1 A0A017HUM1 A0A023YZL3 A0A023YZL3 A0A024KCW9 A0A024KCW9
(622 more...)
Dihydroorotate dehydrogenase (NAD(+)). [EC: 1.3.1.14]
(S)-dihydroorotate + NAD(+) = orotate + NADH.
  • The enzyme consists of two subunits, an FMN binding catalytic subunit and a FAD and iron-sulfur binding electron transfer subunit.
  • The reaction, which takes place in the cytosol, is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides.
  • Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NADP(+) (EC 1.3.1.15) as electron acceptor.
  • The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.
 546 A0A015SIE5 A0A015SIE5 A0A015VAE9 A0A015VAE9 A0A015ZK35 A0A015ZK35 A0A016DHL2 A0A016DHL2 A0A016E7M1 A0A016E7M1
(536 more...)
Dihydroorotate oxidase (fumarate). [EC: 1.3.98.1]
(S)-dihydroorotate + fumarate = orotate + succinate.
  • The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides.
  • Molecular oxygen can replace fumarate in vitro.
  • Other class 1 dihydroorotate dehydrogenases use either NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor.
  • The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.
  • Formerly EC 1.3.3.1.
 408 A0A031WJM7 A0A031WJM7 A0A062WN26 A0A062WN26 A0A062XKF0 A0A062XKF0 A0A075FZ97 A0A075FZ97 A0A075G1L9 A0A075G1L9
(398 more...)
Transferred entry: 1.3.98.1. [EC: 1.3.3.1]
    		60 A0A031WJM7 A0A031WJM7 A0A0H3N7G9 A0A0H3N7G9 A0A0J0UET5 A0A0J0UET5 A0A125VA08 A0A125VA08 A0A1F2DDC8 A0A1F2DDC8
    (50 more...)
    Dihydroorotate dehydrogenase (quinone). [EC: 1.3.5.2]
    (S)-dihydroorotate + a quinone = orotate + a quinol.
    • This Class 2 dihydroorotate dehydrogenase enzyme contains FMN.
    • The enzyme is found in eukaryotes in the mitochondrial membrane, in cyanobacteria, and in some Gram-negative and Gram-positive bacteria associated with the cytoplasmic membrane.
    • The reaction is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides.
    • The best quinone electron acceptors for the enzyme from bovine liver are ubiquinone-6 and ubiquinone-7, although simple quinones, such as benzoquinone, can also act as acceptor at lower rates.
    • Methyl-, ethyl-, tert-butyl and benzyl-(S)-dihydroorotates are also substrates, but methyl esters of (S)-1-methyl and (S)-3-methyl and (S)-1,3-dimethyldihydroorotates are not.
    • Class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1), NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor.
    • Formerly EC 1.3.99.11.
    		 42 A0A085IBQ9 A0A085IBQ9 A0A091C2Q4 A0A091C2Q4 A0A0M0WR40 A0A0M0WR40 A0A0Q6HL91 A0A0Q6HL91 A0A0Q9GNR9 A0A0Q9GNR9
    (32 more...)
    Dihydropyrimidinase. [EC: 3.5.2.2]
    5,6-dihydrouracil + H(2)O = 3-ureidopropanoate.
    • Also acts on dihydrothymine and hydantoin.
    		 8 A0A0B2QTY7 A0A0B2QTY7 A0A0B2SA68 A0A0B2SA68 C6TKV3 C6TKV3 I1KJ84 I1KJ84
    Transferred entry: 1.14.19.20. [EC: 1.14.21.6]
      		2 A8LIZ1 A8LIZ1
      Transferred entry: 1.3.5.2. [EC: 1.3.99.11]
        		2 D0VWT2 D0VWT2
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