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CATH Superfamily 3.20.20.70

Aldolase class I

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 120607: Putative L-lysine 2,3-aminomutase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Lysine 2,3-aminomutase. [EC: 5.4.3.2]
L-lysine = (3S)-3,6-diaminohexanoate.
  • This enzyme is a member of the 'AdoMet radical' (radical SAM) family.
  • It contains pyridoxal phosphate and a [4Fe-4S] cluster and binds an exchangeable S-adenosyl-L-methionine molecule.
  • Activity in vitro requires a strong reductant such as dithionite and strictly anaerobic conditions.
  • A 5'-deoxyadenosyl radical is generated during the reaction cycle by reductive cleavage of S-adenosyl-L-methionine, mediated by the iron- sulfur cluster.
  • S-adenosyl-L-methionine is regenerated at the end of the reaction.
 2076 A0A009GMK8 A0A009GMK8 A0A009IRB2 A0A009IRB2 A0A009RG32 A0A009RG32 A0A010QXL1 A0A010QXL1 A0A017H343 A0A017H343
(2066 more...)
Glutamate 2,3-aminomutase. [EC: 5.4.3.9]
L-glutamate = 3-aminopentanedioate.
  • This enzyme is a member of the 'AdoMet radical' (radical SAM) family.
  • It contains pyridoxal phosphate and a [4Fe-4S] cluster, which is coordinated by 3 cysteines and binds an exchangeable S-adenosyl-L- methionine molecule.
  • During the reaction cycle, the AdoMet forms a 5'-deoxyadenosyl radical, which is regenerated at the end of the reaction.
 50 A0A031WIJ4 A0A031WIJ4 A0A088T1K7 A0A088T1K7 A0A0H3N8J8 A0A0H3N8J8 A0A0H5SGS0 A0A0H5SGS0 A0A0J1FQ51 A0A0J1FQ51
(40 more...)
D-alanine--D-alanine ligase. [EC: 6.3.2.4]
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.
  • Involved with EC 6.3.2.7 or EC 6.3.2.13, EC 6.3.2.8, EC 6.3.2.9 and EC 6.3.2.10 in the synthesis of a cell-wall peptide.
 2 A0A1F6QGX9 A0A1F6QGX9