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CATH Superfamily 3.20.20.70

Aldolase class I

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 120507: 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synth...

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase. [EC: 2.2.1.10]
L-aspartate 4-semialdehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate = 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + 2,3- dioxopropylaldehyde phosphate.
  • The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
  • The enzyme can also catalyze the cleavage of fructose-1,6- bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate.
  • Formerly EC 4.1.2.n5.
 1138 A0A060HNK9 A0A060HNK9 A0A062V659 A0A062V659 A0A063ZFJ7 A0A063ZFJ7 A0A063ZH38 A0A063ZH38 A0A063ZRK7 A0A063ZRK7
(1128 more...)
3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase. [EC: 2.3.1.245]
Glycerone phosphate + acetyl-CoA = 3-hydroxy-5-phosphonooxypentane-2,4- dione + coenzyme A.
  • The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2.
 966 A0A022PJX1 A0A022PJX1 A0A023YXM1 A0A023YXM1 A0A024KWM4 A0A024KWM4 A0A025BX82 A0A025BX82 A0A026S5F8 A0A026S5F8
(956 more...)
Fructose-bisphosphate aldolase. [EC: 4.1.2.13]
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
  • Also acts on (3S,4R)-ketose 1-phosphates.
  • The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc.
  • Formerly EC 4.1.2.7.
 124 A0A090NH93 A0A090NH93 A0A0A6ZSM5 A0A0A6ZSM5 A0A0C5BR67 A0A0C5BR67 A0A0F2Q8Y3 A0A0F2Q8Y3 A0A0F7ICG9 A0A0F7ICG9
(114 more...)
DNA helicase. [EC: 3.6.4.12]
ATP + H(2)O = ADP + phosphate.
  • DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA.
  • Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15).
  • Some helicases unwind DNA as well as RNA (4,9).
  • May be identical with EC 3.6.4.13 (RNA helicase).
 8 A0A081RPB9 A0A081RPB9 A0A081S6N5 A0A081S6N5 A0A087RRJ4 A0A087RRJ4 A0A087RWI1 A0A087RWI1
2-amino-4,5-dihydroxy-6-oxo-7-(phosphonooxy)heptanoate synthase. [EC: 4.1.2.56]
2-amino-4,5-dihydroxy-6-oxo-7-(phosphonooxy)heptanoate = glycerone phosphate + L-aspartate 4-semialdehyde.
  • Part of the pathway for the biosynthesis of grixazone, a mixture of yellow pigments produced by the bacterium Streptomyces griseus.
  • Formerly EC 4.1.2.n6.
 8 A0A1A9DVF2 A0A1A9DVF2 A0A1C4SQN5 A0A1C4SQN5 A0JC77 A0JC77 B1VTI8 B1VTI8
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