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CATH Superfamily 3.20.20.70

Aldolase class I

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 120487: Dihydroorotate dehydrogenase (quinone), mitochondr...

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Dihydroorotate dehydrogenase (quinone). [EC: 1.3.5.2]
(S)-dihydroorotate + a quinone = orotate + a quinol.
  • This Class 2 dihydroorotate dehydrogenase enzyme contains FMN.
  • The enzyme is found in eukaryotes in the mitochondrial membrane, in cyanobacteria, and in some Gram-negative and Gram-positive bacteria associated with the cytoplasmic membrane.
  • The reaction is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides.
  • The best quinone electron acceptors for the enzyme from bovine liver are ubiquinone-6 and ubiquinone-7, although simple quinones, such as benzoquinone, can also act as acceptor at lower rates.
  • Methyl-, ethyl-, tert-butyl and benzyl-(S)-dihydroorotates are also substrates, but methyl esters of (S)-1-methyl and (S)-3-methyl and (S)-1,3-dimethyldihydroorotates are not.
  • Class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1), NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor.
  • Formerly EC 1.3.99.11.
 17594 A0A009F7P9 A0A009F7P9 A0A009GJ21 A0A009GJ21 A0A009GVT5 A0A009GVT5 A0A009H465 A0A009H465 A0A009IN36 A0A009IN36
(17584 more...)
Dihydroorotate oxidase (fumarate). [EC: 1.3.98.1]
(S)-dihydroorotate + fumarate = orotate + succinate.
  • The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides.
  • Molecular oxygen can replace fumarate in vitro.
  • Other class 1 dihydroorotate dehydrogenases use either NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor.
  • The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.
  • Formerly EC 1.3.3.1.
 480 A0A024KTJ4 A0A024KTJ4 A0A026UIE0 A0A026UIE0 A0A027U741 A0A027U741 A0A027ZL34 A0A027ZL34 A0A028E7N3 A0A028E7N3
(470 more...)
Transferred entry: 1.3.98.1. [EC: 1.3.3.1]
    		8 E6PWA3 E6PWA3 E6QBF2 E6QBF2 E6QU29 E6QU29 Q4UDM3 Q4UDM3
    Dihydroorotate dehydrogenase (NAD(+)). [EC: 1.3.1.14]
    (S)-dihydroorotate + NAD(+) = orotate + NADH.
    • The enzyme consists of two subunits, an FMN binding catalytic subunit and a FAD and iron-sulfur binding electron transfer subunit.
    • The reaction, which takes place in the cytosol, is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides.
    • Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NADP(+) (EC 1.3.1.15) as electron acceptor.
    • The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.
    		 8 A0A0F4Z308 A0A0F4Z308 A2QCB1 A2QCB1 G5EB61 G5EB61 Q12610 Q12610
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