View in Gene3D

CATH Superfamily 3.20.20.70

Aldolase class I

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 120179: Uridine monophosphate synthetase isoform I

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Orotidine-5'-phosphate decarboxylase. [EC: 4.1.1.23]
Orotidine 5'-phosphate = UMP + CO(2).
  • The enzyme from higher eukaryotes is identical with EC 2.4.2.10.
 1248 A0A017SK94 A0A017SK94 A0A022PXM5 A0A022PXM5 A0A022VYP6 A0A022VYP6 A0A022XP96 A0A022XP96 A0A058Z9F9 A0A058Z9F9
(1238 more...)
Orotate phosphoribosyltransferase. [EC: 2.4.2.10]
Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
  • The enzyme from higher eukaryotes also catalyzes the reaction listed as EC 4.1.1.23.
 64 A0A090D061 A0A090D061 A0A0B2QN51 A0A0B2QN51 A0A0B2S0I4 A0A0B2S0I4 A0A101C6W4 A0A101C6W4 A0A151RDY2 A0A151RDY2
(54 more...)
DNA-(apurinic or apyrimidinic site) lyase. [EC: 4.2.99.18]
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
  • 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis.
  • This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.
 12 A0A061H884 A0A061H884 A0A066W594 A0A066W594 A0A0M9VPL5 A0A0M9VPL5 A8PTB8 A8PTB8 M5EDG0 M5EDG0
(2 more...)