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CATH Superfamily 3.20.20.70

Aldolase class I

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 119956: Thiazole biosynthesis protein thiG

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Thiazole synthase. [EC: 2.8.1.10]
1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-[sulfur- carrier protein ThiS] = 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)- ylidene)ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H(2)O.
  • H(2)S can provide the sulfur in vitro.
  • Part of the pathway for thiamine biosynthesis.
 16554 A0A009F1Z7 A0A009F1Z7 A0A009G2Y0 A0A009G2Y0 A0A009GWA4 A0A009GWA4 A0A009HKK9 A0A009HKK9 A0A009I7U0 A0A009I7U0
(16544 more...)
2-iminoacetate synthase. [EC: 4.1.99.19]
L-tyrosine + S-adenosyl-L-methionine + NADPH = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+) + H(+).
  • Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule.
  • The first stage of catalysis is reduction of the S-adenosyl-L- methionine to produce methionine and a 5-deoxyadenosin-5-yl radical that is crucial for the conversion of the substrate.
  • Part of the pathway for thiamine biosynthesis.
  • Formerly EC 1.3.99.n2.
 6 A0A0K2DWI2 A0A0K2DWI2 A0A0K2L4P1 A0A0K2L4P1 A0A1L9F208 A0A1L9F208
Glycine oxidase. [EC: 1.4.3.19]
Glycine + H(2)O + O(2) = glyoxylate + NH(3) + H(2)O(2).
  • The enzyme from Bacillus subtilis is active with glycine, sarcosine, N-ethylglycine, D-alanine, D-alpha-aminobutyrate, D-proline, D-pipecolate and N-methyl-D-alanine.
  • It differs from EC 1.4.3.3 due to its activity on sarcosine and D-pipecolate.
  • The intermediate 2-iminoacetate is used directly by EC 2.8.1.10.
 2 M1WVC5 M1WVC5
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