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CATH Superfamily 3.20.20.70

Aldolase class I

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 119618: Keto-hydroxyglutarate-aldolase/keto-deoxy-phosphog...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-dehydro-3-deoxy-phosphogluconate aldolase. [EC: 4.1.2.14]
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.
  • The enzyme shows no activity with 2-dehydro-3-deoxy-6-phosphate-D- galactonate (cf. EC 4.1.2.55).
  • Also acts on 2-oxobutanoate.
 60 A0A059UWB1 A0A067AGF6 A0A080W0D9 A0A084CBI2 A0A086BZM3 A0A088P449 A0A089WK78 A0A099EA13 A0A099MUE4 A0A0A7JGY2
(50 more...)
4-hydroxy-2-oxoglutarate aldolase. [EC: 4.1.3.16]
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
  • The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate.
  • Formerly EC 4.1.2.1 and EC 4.1.2.31.
 52 A0A059UWB1 A0A080W0D9 A0A084CBI2 A0A086BZM3 A0A088P449 A0A089WK78 A0A099EA13 A0A099MUE4 A0A0A7JGY2 A0A0A7PRF5
(42 more...)
Oxaloacetate decarboxylase. [EC: 4.1.1.3]
Oxaloacetate = pyruvate + CO(2).
  • The enzyme from Klebsiella aerogenes is a biotinyl protein and also decarboxylates glutaconyl-CoA and methylmalonyl-CoA.
  • The process is accompanied by the extrusion of two sodium ions from cells.
  • Some animal enzymes require manganese.
 1 Q88P29