The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16033: Phosphoinositide-3-kinase, catalytic, alpha polype...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
28 A0A061IHE6 A0A061IHE6 A0A096MY63 A0A096MY63 A0A0D9RKI4 A0A0D9RKI4 A0A0G2K344 A0A0G2K344 D2GUC9 D2GUC9
(18 more...)
Phosphatidylinositol-4,5-bisphosphate 3-kinase. [EC: 2.7.1.153]
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
  • This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
26 A0A096MY63 A0A096MY63 A0A0D9RKI4 A0A0D9RKI4 A0A0G2K344 A0A0G2K344 D2GUC9 D2GUC9 F1Q3M8 F1Q3M8
(16 more...)