The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
C2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15251: Phospholipase C beta 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 A2AT91 (/IPI) P13217 (/IPI) Q15147 (/IPI) Q5FWA6 (/IPI) Q91UZ1 (/IPI) V9GXQ9 (/IPI)
Phosphatidylinositol phospholipase C activity GO:0004435
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
2 P13217 (/TAS) Q15147 (/TAS)
Phospholipase C activity GO:0004629
Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.
2 P13217 (/TAS) Q15147 (/TAS)
Phosphatidylinositol phospholipase C activity GO:0004435
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
1 P13217 (/IMP)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 P13217 (/NAS)
Mitogen-activated protein kinase binding GO:0051019
Interacting selectively and non-covalently with a mitogen-activated protein kinase.
1 Q9QW07 (/IPI)

There are 34 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580
The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.
1 P13217 (/IMP)
Mucosal immune response GO:0002385
An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract.
1 P13217 (/IMP)
Phospholipid metabolic process GO:0006644
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
1 P13217 (/TAS)
Diacylglycerol biosynthetic process GO:0006651
The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.
1 P13217 (/TAS)
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 G5EBH0 (/IGI)
Dopamine receptor signaling pathway GO:0007212
The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.
1 G5EBH0 (/IMP)
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
1 P13217 (/IMP)
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
1 Q9QW07 (/NAS)
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
1 P13217 (/TAS)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
1 P13217 (/IMP)
Light-induced release of internally sequestered calcium ion GO:0008377
The process in which the detection of light triggers the release of internally sequestered calcium ions.
1 P13217 (/TAS)
Phospholipid biosynthetic process GO:0008654
The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
1 P13217 (/TAS)
Entrainment of circadian clock GO:0009649
The synchronization of a circadian rhythm to environmental time cues such as light.
1 P13217 (/IMP)
Positive regulation of acetylcholine secretion, neurotransmission GO:0014057
Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine.
1 G5EBH0 (/IMP)
Rhodopsin mediated signaling pathway GO:0016056
The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response.
1 P13217 (/IMP)
Deactivation of rhodopsin mediated signaling GO:0016059
The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon).
1 P13217 (/IDA)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
1 P13217 (/TAS)
Protein localization to synapse GO:0035418
Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
1 G5EBH0 (/IGI)
Regulation of locomotion GO:0040012
Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.
1 G5EBH0 (/IGI)
Positive regulation of locomotion GO:0040017
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
1 G5EBH0 (/IMP)
Regulation of pharyngeal pumping GO:0043051
Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes.
1 G5EBH0 (/IGI)
Regulation of pharyngeal pumping GO:0043051
Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes.
1 G5EBH0 (/IMP)
Thermotaxis GO:0043052
The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature.
1 G5EBH0 (/IGI)
Thermotaxis GO:0043052
The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature.
1 P13217 (/IMP)
Entrainment of circadian clock by photoperiod GO:0043153
The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
1 P13217 (/IGI)
Negative regulation of potassium ion transport GO:0043267
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9QW07 (/IMP)
Inositol phosphate metabolic process GO:0043647
The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
1 Q15147 (/TAS)
Photoreceptor cell maintenance GO:0045494
Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light.
1 P13217 (/IMP)
Phosphatidylinositol metabolic process GO:0046488
The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
1 P13217 (/IMP)
Regulation of oviposition GO:0046662
Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium.
1 G5EBH0 (/IMP)
Negative regulation of compound eye retinal cell programmed cell death GO:0046673
Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.
1 P13217 (/IMP)
Positive regulation of axon regeneration GO:0048680
Any process that activates, maintains or increases the rate of axon regeneration.
1 G5EBH0 (/IMP)
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482
Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G-protein coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol.
1 P13217 (/TAS)
Positive regulation of clathrin-dependent endocytosis GO:2000370
Any process that activates or increases the frequency, rate or extent of clathrin-mediated endocytosis.
1 P13217 (/IMP)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 A2AT91 (/IDA) Q5FWA6 (/IDA) Q91UZ1 (/IDA) V9GXQ9 (/IDA)
Smooth endoplasmic reticulum GO:0005790
The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
4 A2AT91 (/IDA) Q5FWA6 (/IDA) Q91UZ1 (/IDA) V9GXQ9 (/IDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane in asymetric synapses. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
4 A2AT91 (/IDA) Q5FWA6 (/IDA) Q91UZ1 (/IDA) V9GXQ9 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
4 A2AT91 (/IDA) Q5FWA6 (/IDA) Q91UZ1 (/IDA) V9GXQ9 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9QW07 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q15147 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 G5EBH0 (/IDA)
InaD signaling complex GO:0016027
A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD.
1 P13217 (/IPI)
InaD signaling complex GO:0016027
A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD.
1 P13217 (/TAS)
Rhabdomere GO:0016028
The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction.
1 P13217 (/IDA)
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