CATH Superfamily 2.60.40.150

Browse Functional Families

ID	Function Family (FunFam) Name	Total Sequences	Enzyme?	Structure?	Structural Representative	PDB Sites?	Alignment Diversity (0-100)
15515	Phosphoinositide phospholipase C 4	3668	EC	3D	1djgA03	-	84.8
15384	Synaptotagmin 1, isoform I	2698	EC	3D	2k45A00	-	80.4
15294	Regulating synaptic membrane exocytosis 2	2628		3D	2q3xA00	-	92.9
15522	Copine-1 isoform b	2077			-	-	84.7
15615	E3 ubiquitin-protein ligase SMURF1	1967	EC	3D	3pycA00	-	81.1
15298	Dysferlin Predicted	1752			-	-	80.7
15577	Small nuclear ribonucleoprotein helicase	1587	EC	3D	4f91B06	-	86.4
15501	Dysferlin Predicted	1583			-	-	93.9
15595	Extended synaptotagmin-like protein 2	1492	EC	3D	4npjA01	-	84.0
15270	Synaptotagmin-like 4, isoform CRA_b	1367	EC		-	-	95.0
15465	Dysferlin Predicted	1307			-	-	90.9
15265	C2 calcium/lipid-binding plant phosphoribosyltransferase family protein	1250	EC		-	-	93.7
15557	Protein unc-13 homolog B	1180		3D	3kwtA00	-	92.1
15044	Regulating synaptic membrane exocytosis 2	1090		3D	1v27A00	-	61.0
15126	Protein unc-13 homolog A	1087		3D	2cjsA01	-	63.7
15463	Ras GTPase-activating protein gap-2	1014			-	-	86.6
15108	Synaptotagmin 1, isoform I	999	EC	3D	2lhaA00	-	89.9
15485	C2 calcium/lipid-binding plant phosphoribosyltransferase family protein	985	EC		-	-	96.4
15224	Protein unc-13 homolog B	948			-	-	91.3
15480	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta	899	EC	3D	2dmgA00	-	83.7
15443	Dysferlin Predicted	891			-	-	89.4
15254	Calcium-dependent protein kinase C	864	EC	3D	4dnlA00	-	81.9
15482	Coffea canephora DH200=94 genomic scaffold, scaffold_22	776	EC		-	-	91.3
15604	Phosphatidylserine decarboxylase proenzyme 3	756	EC		-	-	92.2
15478	Protein kinase C, epsilon	729	EC	3D	1gmiA00	-	87.7
15469	Extended synaptotagmin-2	686		3D	4npjA02	-	91.9
15251	Phospholipase C beta 4	630	EC		-	-	59.7
15701	C2 domain-containing protein 3	615			-	-	95.5
15035	Synaptotagmin III, isoform CRA_a	611		3D	1dqvA02	-	73.5
15219	Copine-9 isoform 1	563			-	-	83.5
15464	C2 domain-containing protein	563	EC		-	-	96.5
15367	Double C2-like domain-containing protein beta	561		3D	2cm5A00	-	95.5
15221	Phosphoinositide phospholipase C	559	EC	3D	3ohmB04	-	89.5
15347	Rab11 family-interacting protein 1	543			-	-	89.0
15495	Small nuclear ribonucleoprotein 200kDa	506	EC	3D	2q0zX03	-	88.7
15373	FER-1-like protein 4	504			-	-	86.9
15589	DNA-directed RNA polymerase II subunit J	502			-	-	99.7
15660	Coiled-coil and C2 domain-containing protein 2A	436			-	-	77.6
15132	Intersectin 1 SH3 domain protein	431		3D	3jzyA00	-	83.3
15724	Protein kinase C delta type	417	EC	3D	1yrkA00	-	91.3
15356	Phosphoinositide phospholipase C	416	EC		-	-	82.1
15063	Oncorhynchus mykiss genomic scaffold, scaffold_1428	404			-	-	86.4
15563	Ras GTPase-activating protein 4	393			-	-	73.8
15439	Dysferlin variant a	391		3D	4ihbA00	-	86.6
15230	Double C2-like domain-containing protein alpha	388		3D	2k3hA00	-	73.1
15025	SYT14 protein	379			-	-	81.7
15183	Breakpoint cluster region protein	362	EC		-	-	75.8
15244	cDNA FLJ51064, highly similar to Synaptotagmin-4	330		3D	1w15A00	-	87.0
15674	Calpain 5, isoform CRA_a	317			-	-	98.3
15365	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1	311		3D	2yrbA01	-	91.4
15103	E3 ubiquitin-protein ligase HECW2	291	EC		-	-	69.0
15597	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	285	EC	3D	2enqA00	-	87.7
15692	Putative calpain-like cysteine protease A	284	EC		-	-	86.7
1529	Synaptotagmin-like 2, isoform CRA_b	280			-	-	55.5
15562	Protein kinase C-like 2	275	EC		-	-	89.7
5876	C2 domain-containing protein 5	273			-	-	63.7
7853	Multiple C2 and transmembrane domain-containing protein 1	271			-	-	75.7
15131	E3 ubiquitin-protein ligase NEDD4	267	EC	3D	3b7yA00	-	79.4
15479	Activating signal cointegrator 1 complex subunit 3	249	EC		-	-	91.8
15008	Synaptotagmin VII, isoform CRA_b	243		3D	3n5aA00	-	63.2
14991	Oncorhynchus mykiss genomic scaffold, scaffold_4696	242			-	-	78.6
5344	Oncorhynchus mykiss genomic scaffold, scaffold_4696	238			-	-	78.9
15259	Serine/threonine-protein kinase N2	238	EC		-	-	82.9
15240	Phospholipase D alpha 1	234	EC		-	-	88.6
15210	Phosphatidylinositol 3-kinase gamma isoform	231	EC	3D	1e8yA02	-	77.0
15525	Conserved serine proline-rich protein AFU_orthologue AFUA_2G01790	230			-	-	85.0
222	Dedicator of cytokinesis protein 7	229			-	-	75.0
14997	Toll-interacting protein B	228			-	-	45.7
15398	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1	225		3D	4qamB00	-	92.5
3528	Multiple C2 domains, transmembrane 2	220			-	-	90.2
15328	Plant synaptotagmin	220	EC		-	-	89.1
15168	Phosphoinositide phospholipase C	218	EC		-	-	79.4
15312	Synaptotagmin-like protein 1 isoform 1	207			-	-	87.9
15389	Phosphatidylinositol 3-kinase catalytic subunit type 3	207	EC		-	-	92.3
15243	C2 and GRAM domain-containing protein	202	EC		-	-	85.3
15624	Probable transmembrane protein	201			-	-	95.6
8153	Uncharacterized protein	196			-	-	0.0
7325	Multiple C2 and transmembrane domain-containing protein 1	189			-	-	71.2
15725	Fer-1-like protein 4	186		3D	3l9bA00	-	81.7
15199	Cytosolic phospholipase A2	185	EC	3D	1bciA00	-	80.5
5311	Synaptotagmin-14 isoform 2	176			-	-	50.5
14995	Similar to Piccolo protein Aczonin	170		3D	1rh8A00	-	52.6
3540	Multiple C2 and transmembrane domain-containing protein 1	161			-	-	78.0
15489	Uncharacterized protein PYUK71.03c	160			-	-	92.9
15467	BAI1-associated protein 3	158			-	-	83.2
15015	Phosphatidylinositol 3-kinase delta catalytic subunit	157	EC	3D	2wxfA03	-	79.1
1301	Synaptotagmin XVII, isoform CRA_a	156		3D	2enpA00	-	40.8
15084	Dysferlin Predicted	154			-	-	67.5
15160	Ras GTPase-activating protein 1	153			-	-	56.3
6746	Multiple C2 and transmembrane domain-containing protein 2	149		3D	2ep6A01	-	58.0
15102	Translocation protein SEC63 homolog	146			-	-	71.0
14097	UV radiation resistance associated protein	146			-	-	74.3
15053	Centrosomal protein of 120 kDa	145		3D	4icwA00	-	68.3
15031	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha	144	EC	3D	2b3rA00	-	67.2
15407	Coiled-coil and C2 domain-containing protein 1B	143			-	-	78.1
15633	Serine/threonine-protein kinase SCH9	141	EC		-	-	96.3
9933	Type I inositol 3,4-bisphosphate 4-phosphatase	139	EC		-	-	37.0
15286	Synaptotagmin XVII, isoform CRA_a	131			-	-	63.5
8048	Multiple C2 and transmembrane domain-containing protein 2	130			-	-	73.7
9270	Uncharacterized protein	130			-	-	36.4
15584	Phosphoinositide-specific phospholipase C [Source:UniProtKB/TrEMBLAcc:P78614]	128	EC		-	-	89.9
15154	Phosphoinositide phospholipase C	127	EC	3D	2fjuB04	-	73.1
15151	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha	127	EC		-	-	79.7
15124	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide	124	EC		-	-	50.6
15095	Ras GTPase-activating protein 3	124			-	-	68.4
15348	Calcium-dependent lipid-binding domain-containing protein	122	EC		-	-	93.6
15433	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma	117	EC		-	-	89.4
15147	RasGAP-activating-like protein 1	116			-	-	69.2
6641	Protein KIBRA isoform 1	115		3D	2z0uA00	-	82.5
14974	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform	107	EC	3D	2y3aA02	-	64.5
7857	Cellulose synthase-interactive protein 1	107			-	-	62.0
2523	MKIAA0765 splice variant 1	106			-	-	83.6
15021	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide	102	EC		-	-	68.0
118	Phosphatidylinositol 3-kinase	101	EC		-	-	0.0
15165	Synaptotagmin-15	99			-	-	74.9
3304	Synaptotagmin-like protein 5	97			-	-	31.8
15076	Cytosolic phospholipase A2 epsilon	95	EC		-	-	62.5
9426	Coiled-coil and C2 domain-containing protein 1A	94			-	-	62.1
15162	Type II inositol 3,4-bisphosphate 4-phosphatase	93	EC		-	-	69.6
15336	RasGAP-activating-like protein 1	84			-	-	67.0
5705	Dysferlin	83			-	-	57.1
622	Ras GTPase-activating protein 2	82			-	-	38.6
5439	Rab3 interacting molecule, isoform U	82		3D	4ts6A00	-	20.4
12298	Dedicator of cytokinesis 1	82		3D	3l4cA00	-	20.0
15203	Ras GTPase-activating protein 4	81			-	-	63.2
15020	Protein unc-13 homolog D	80			-	-	53.9
4745	Protein kinase C, eta	80	EC	3D	2fk9A00	-	52.9
15218	Cytosolic phospholipase A2 zeta	77	EC		-	-	70.3
5708	Leucine-rich repeat-containing protein 16B	77			-	-	52.6
15184	Synaptotagmin-like 3, isoform CRA_d	76			-	-	67.3
4224	Synaptotagmin-like 4, isoform CRA_a	75		3D	3fdwA00	-	50.6
3401	Tandem C2 domains nuclear protein	72			-	-	38.1
15157	Extended synaptotagmin-1	72			-	-	75.8
15187	Activating signal cointegrator 1 complex subunit 3	70	EC		-	-	59.0
15509	Tcb1p	68			-	-	81.3
5309	Dysferlin Predicted	66			-	-	38.8
5963	Bitesize isoform 1	66			-	-	12.3
11652	Phosphoinositide phospholipase C	65	EC		-	-	42.3
598	BAI1-associated protein 3 isoform 1	65			-	-	44.3
15234	Perforin 1 Pore forming protein	64		3D	3nsjA02	-	68.3
15121	Synaptotagmin-13	64		3D	1wfmA00	-	61.5
15065	Fer-1-like protein 4	63			-	-	64.5
14992	Synaptotagmin-like 3, isoform CRA_d	61			-	-	54.4
15050	Copine-7	61			-	-	61.3
14958	Protein unc-13 homolog D	59			-	-	29.9
2297	Nedd4, isoform L	58	EC		-	-	22.5
3431	C2 domain-containing protein 2-like	56			-	-	71.2
2284	Copine III, isoform CRA_a	54			-	-	47.1
1807	Synaptotagmin-13	54			-	-	30.3
5547	Synaptotagmin-16	53			-	-	45.4
2607	Synaptotagmin 7, isoform A	52			-	-	18.7
15733	UNC-31, isoform n	51	EC		-	-	71.5
15130	Synaptotagmin-8	51			-	-	73.6
14981	C2 domain-containing protein 3	51			-	-	51.9
1798	cDNA, FLJ79459, highly similar to Synaptotagmin-12	48			-	-	25.6
15678	Uncharacterized protein C11E3.02c	48			-	-	57.7
4491	cDNA, FLJ79459, highly similar to Synaptotagmin-12	47			-	-	38.5
1680	TCB3-like protein	45			-	-	21.8
15282	Calcium-dependent lipid-binding domain-containing protein	45			-	-	59.9
6116	C2 domain-containing protein 3	44			-	-	58.0
5952	Inn1p	43			-	-	6.2
15702	BON association protein 1	43			-	-	75.8
15145	Phospholipase D gamma 2	41	EC		-	-	67.6
1136	YGR170Wp-like protein	41	EC		-	-	39.2
15148	Protein BONZAI 2	40			-	-	68.3
15448	Inhibitory regulator protein BUD2/CLA2	39			-	-	15.2
15061	Tandem C2 domains nuclear protein	38			-	-	40.9
13087	Fer-1-like protein 5	38			-	-	28.6
14660	Breakpoint cluster region protein	36			-	-	62.1
10390	DEIH-box ATPase	36	EC		-	-	1.1
15248	RAS protein activator like-3	36			-	-	41.7
4340	Phosphoinositide phospholipase C	35	EC		-	-	15.5
15037	Regulator of G-protein signaling 3	35		3D	3fbkA00	-	47.0
15051	Synaptotagmin-8	35			-	-	46.8
15717	Meiotically up-regulated gene 190 protein	35			-	-	76.0
5985	Rab11 interacting protein, isoform A	35			-	-	22.8
15182	Cytosolic phospholipase A2 delta	34	EC		-	-	50.5
14993	cDNA FLJ53718, highly similar to Synaptotagmin-15	33			-	-	30.3
6002	Synaptotagmin 14, isoform D	32			-	-	32.0
2481	cDNA, clone: J100024I19, full insert sequence	28			-	-	2.7
15211	Phosphatidylserine decarboxylase proenzyme 2	28	EC		-	-	46.8
4220	No pollen	26			-	-	20.5
15631	Misfire, isoform B	26			-	-	74.4
15013	C2 domain-containing protein 3	25			-	-	15.6
11102	CG9209-PA, isoform A	25			-	-	16.8
13574	Centrosomal protein of 120 kDa	25			-	-	19.5
15583	Phosphoinositide 3-kinase	24	EC		-	-	64.4
434	Rabphilin, isoform A	22			-	-	44.9
829	Sec63p	21			-	-	14.2
13239	Intersectin-1	20			-	-	50.0
7998	Serine/threonine-protein kinase N1	20	EC		-	-	29.7
15450	Phosphatidylinositol 3-kinase, root isoform	20	EC		-	-	62.0
1228	Synaptotagmin 14, isoform D	20			-	-	8.5
12731	Myoblast city, isoform B	19			-	-	20.1
15146	Misfire, isoform I	19			-	-	57.3
1175	Phosphatidylserine decarboxylase	19	EC		-	-	16.1
3963	IP03351p	18			-	-	14.1
9693	GTPase activating protein BUD2	18			-	-	12.4
4800	FI17803p1	18			-	-	12.1
10124	C2 domain-containing protein	18			-	-	23.0
956	Synaptotagmin alpha, isoform A	18			-	-	29.8
1290	Rabphilin, isoform A	18			-	-	16.9
15738	Protein C2cd3	18			-	-	69.7
7520	E3 ubiquitin-protein ligase Su dx	17	EC		-	-	20.7
14982	ADP-ribosylation factor GTPase-activating protein AGD12	17			-	-	15.0
2931	At5g47710	16			-	-	34.0
14749	Fer-1-like protein 5	16			-	-	33.5
3449	Uncharacterized protein	16			-	-	11.8
5643	Protein kibra	16			-	-	10.6
8882	GL26342	15			-	-	31.4
10186	Uncharacterized protein	15			-	-	3.5
5046	Probable ADP-ribosylation factor GTPase-activating protein AGD11	15			-	-	12.2
15166	Cytosolic phospholipase A2 beta	14	EC		-	-	37.8
3509	Translocation protein SEC63	13			-	-	6.1
7387	Lethal with a checkpoint kinase, isoform B	13	EC		-	-	6.3
9818	Kinesin-like protein KIF13B	12			-	-	42.7
13862	Coiled-coil domain-containing protein 33	12			-	-	24.8
875	Protostome-specific GEF, isoform H	12			-	-	11.8
11420	Fer-1-like protein 5	12			-	-	24.0
5953	Protein BONZAI 3	12			-	-	49.3
9880	No pollen	12			-	-	10.9
3271	Misfire, isoform I	12			-	-	2.2
11022	FER-1-like protein 5	12			-	-	7.8
7779	Protein kinase C, eye isozyme	12	EC		-	-	14.8
5294	Src2-like protein	11			-	-	29.9
1365	Serine/threonine-protein kinase N	11	EC		-	-	0.0
7381	Phorbol ester/diacylglycerol-binding protein unc-13	11			-	-	23.5
4493	YNL087Wp-like protein	11			-	-	0.7
15058	C2 domain-containing protein 3	11			-	-	17.7
3156	Rho GTPase-activating protein 100F	10			-	-	0.9
3720	Ras GTPase activating protein 1, isoform C	10			-	-	23.2
79	Misfire, isoform F	10			-	-	16.5
6657	Os06g0297800 protein	9			-	-	0.8
4823	Synaptotagmin alpha, isoform A	9			-	-	13.7
15441	GTPase activating protein BUD2/CLA2 AFU_orthologue AFUA_6G12340	9			-	-	40.3
11092	C2 calcium-dependent domain-containing protein 4A	9			-	-	21.4
2133	Tricalbin-3	8			-	-	5.6
4397	CRE-RBF-1 protein	8			-	-	19.6
15185	Rho GTPase-activating protein syd-1	8			-	-	8.1
7985	R11G1.6, isoform b	7			-	-	12.0
3570	Rab-3-interacting molecule unc-10	7			-	-	14.7
366	Phosphatidylinositol 3-kinase	7	EC		-	-	27.5
15673	Sperm vesicle fusion protein fer-1	7			-	-	69.2
15571	Activating signal cointegrator 1 complex subunit 3	6			-	-	43.4
3881	C2 domain-containing protein	6			-	-	24.3
11320	Rab-3-interacting molecule unc-10	6			-	-	10.3
7531	AEX-1	5			-	-	13.1
11034	Genomic DNA, chromosome 3, P1 clone: MYF24	5			-	-	7.9
10905	GM24241	5			-	-	16.4
5266	C2 and GRAM domain-containing protein At5g50170	5			-	-	7.3
15587	Phosphatidylinositol 3-kinase age-1	5	EC		-	-	54.3
11217	Genomic DNA, chromosome 3, P1 clone: MYF24	4			-	-	6.1
784	Protein CBR-SNT-2	4			-	-	4.9
14261	DEAD/DEAH box helicase, putative	4			-	-	0.0
6648	Protein KIBRA	4			-	-	23.9
15212	Copine-B	3			-	-	31.0
13994	Centrosomal protein of 120 kDa	3			-	-	24.7
881	Expressed protein	3			-	-	8.7
14632	Kinesin-like protein	3			-	-	0.0
6096	C2 and GRAM domain-containing protein At1g03370	3			-	-	3.1
9847	C2 domain-containing protein 2	3			-	-	0.0
3985	N-terminal-transmembrane-C2 domain type 5.1 protein	3			-	-	3.9
10384	Phospholipase D delta	3	EC		-	-	0.0
5777	Unc-13-4A, isoform B	3			-	-	3.8
15540	Probable serine/threonine-protein kinase DDB_G0272092	3	EC		-	-	43.1
15684	Arrestin domain-containing protein C	3			-	-	65.7
4338	LOC557688 protein	2			-	-	2.7
12252	C2 domain-containing protein	2			-	-	2.7
5408	Phosphatidylserine decarboxylase Psd2, putative AFU_orthologue AFUA_3G13970	2	EC		-	-	0.0
15579	Uncharacterized protein C962.01	2			-	-	44.3
3555	Phosphoinositide phospholipase C	2	EC		-	-	0.0
13363	WWP-1, isoform b	2			-	-	0.0
1341	Phospholipase D zeta	2	EC		-	-	2.3
15410	Copine-F	2			-	-	32.6
11044	Phospholipase D epsilon	2	EC		-	-	4.6
14956	Regulating synaptic membrane exocytosis protein 1	2			-	-	0.0
13856	cDNA FLJ13337 fis, clone OVARC1001880	2			-	-	0.0
6145	Uncharacterized protein	2			-	-	0.0
11039	Lipase class 3 family protein	2			-	-	7.6
2305	Sperm vesicle fusion protein fer-1	2			-	-	0.0
4203	Regulator of G-protein signaling rgs-7	2			-	-	0.0
7140	C2 calcium/lipid-binding plant phosphoribosyltransferase family protein	2			-	-	5.2
5583	Misfire, isoform F	2			-	-	1.6
15561	Serine/threonine-protein kinase gad8	1	EC		-	-	0.0
2942	Phosphatidylinositol 3-kinase vps34	1	EC		-	-	0.0
6605	Uncharacterized protein	1			-	-	0.0
13228	Dysf protein	1			-	-	0.0
795	Uncharacterized protein	1			-	-	0.0
11712	Copine-C	1			-	-	0.0
8878	Translocation protein sec63	1			-	-	0.0
10433	Uncharacterized protein	1			-	-	0.0
12704	Uncharacterized protein	1			-	-	0.0
8505	Copine-A	1			-	-	0.0
10391	Activating signal cointegrator 1 complex subunit 3	1			-	-	0.0
1436	Synaptotagmin I	1			-	-	0.0
12554	Unc13d protein	1			-	-	0.0
10393	Copine-B	1			-	-
15693	Tricalbin-1	1			-	-	0.0
5108	Uncharacterized protein	1			-	-	0.0
13807	Uncharacterized protein	1			-	-	0.0
9809	U5 small nuclear ribonucleoprotein-specific protein, putative	1	EC		-	-	0.0