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CATH Superfamily 2.60.120.10

Jelly Rolls

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Jelly Rolls
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 54745: CAMP-dependent kinase, regulatory protein

There are 9 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
CGMP-dependent protein kinase. [EC: 2.7.11.12]
ATP + a protein = ADP + a phosphoprotein.
  • cGMP is required to activate this enzyme.
  • The enzyme occurs as a dimer in higher eukaryotes.
  • The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites.
  • This domain catalyzes the phosphorylation by ATP to specific serine or threonine residues in protein substrates.
  • The enzyme also has two allosteric cGMP-binding sites (sites A and B).
  • Binding of cGMP causes a conformational change that is associated with activation of the kinase.
  • Formerly EC 2.7.1.37.
 924 A0A016RXA8 A0A016RXA8 A0A016RXD8 A0A016RXD8 A0A016RXH8 A0A016RXH8 A0A016RY62 A0A016RY62 A0A016RYF9 A0A016RYF9
(914 more...)
CAMP-dependent protein kinase. [EC: 2.7.11.11]
ATP + a protein = ADP + a phosphoprotein.
  • cAMP is required to activate this enzyme.
  • The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits.
  • cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C).
  • Formerly EC 2.7.1.37.
 62 A0A023B252 A0A023B252 A0A023B252 A0A023B252 A0A023B252 A0A023B252 A0A060RW29 A0A060RW29 A0A0B2PZZ1 A0A0B2PZZ1
(52 more...)
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
 22 A0A061I0E7 A0A061I0E7 A0A061I2S1 A0A061I2S1 A0A061I570 A0A061I570 A0A0B7FXL9 A0A0B7FXL9 A7AWX2 A7AWX2
(12 more...)
Non-specific protein-tyrosine kinase. [EC: 2.7.10.2]
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
  • Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain.
  • In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families.
  • Formerly EC 2.7.1.112.
 8 B7QBH4 B7QBH4 E0VRT6 E0VRT6 L0AUX5 L0AUX5 L7JXT8 L7JXT8
Transferred entry: 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1. [EC: 2.7.1.37]
    		6 Q869J9 Q869J9 Q869J9 Q869J9 Q869K0 Q869K0
    Aminomethyltransferase. [EC: 2.1.2.10]
    [Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH(3).
    • A component, with EC 1.4.4.2 and EC 1.8.1.4, of the glycine cleavage system, formerly known as glycine synthase.
    • The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.
    		 2 A0A176WBQ4 A0A176WBQ4
    3',5'-cyclic-AMP phosphodiesterase. [EC: 3.1.4.53]
    Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
    • Specific for 3',5'-cAMP and does not hydrolyze other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17 and EC 3.1.4.35).
    • It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation.
    • Formerly EC 3.1.4.n1.
    		 2 G0QR60 G0QR60
    Lysophospholipase. [EC: 3.1.1.5]
    2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
      		 2 G0R4B7 G0R4B7
      Protein-serine/threonine phosphatase. [EC: 3.1.3.16]
      [a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
      • A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48).
      • The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).
      		 2 B9RKK9 B9RKK9
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