The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Acid Proteases
".
FunFam 23027: Truncated pol protein
There are 5 EC terms in this cluster
Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
EC Term | Annotations | Evidence |
---|---|---|
RNA-directed DNA polymerase.
[EC: 2.7.7.49]
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
|
279 |
A0A075LUN9
A0A075LUP7
A0A075LUQ4
A0A075LUS4
A0A075LUU7
A0A075LUY4
A0A075LV09
A0A075LV25
A0A075LV31
A0A075LV44 (269 more...) |
HIV-1 retropepsin.
[EC: 3.4.23.16]
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.
|
17 |
A0A0D3MKZ8
F2X1U9
F8TLV6
O41798
O89940
O93215
P17283
P24740
Q1A249
Q1A267 (7 more...) |
Retroviral ribonuclease H.
[EC: 3.1.26.13]
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
|
14 |
O41798
O89940
O93215
P17283
P24740
Q1A249
Q1A267
Q77373
Q79666
Q9IDV9 (4 more...) |
DNA-directed DNA polymerase.
[EC: 2.7.7.7]
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
|
14 |
O41798
O89940
O93215
P17283
P24740
Q1A249
Q1A267
Q77373
Q79666
Q9IDV9 (4 more...) |
Exoribonuclease H.
[EC: 3.1.13.2]
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
|
14 |
O41798
O89940
O93215
P17283
P24740
Q1A249
Q1A267
Q77373
Q79666
Q9IDV9 (4 more...) |