The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Acid Proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 23002: Cathepsin D (A01 family)

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Cathepsin D. [EC: 3.4.23.5]
Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.
  • Occurs intracellularly, in lysosomes.
  • Belongs to peptidase family A1.
  • Formerly EC 3.4.4.23.
15 A0A0S3G4L0 B7QBB2 G3I4W7 O57477 P00795 P07339 P18242 P24268 P80209 P87370
(5 more...)
Renin. [EC: 3.4.23.15]
Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.
  • Belongs to peptidase family A1.
  • Formerly EC 3.4.4.15 and EC 3.4.99.19.
11 P00796 P00797 P06281 P08424 P52115 P60016 Q6DLS0 Q6DLW5 Q6DYE7 Q7M3D2
(1 more...)
Cathepsin E. [EC: 3.4.23.34]
Similar to cathepsin D, but slightly broader specificity.
  • Found in stomach, spleen, erythrocyte membrane; not lysosomal.
  • Pro-cathepsin E is an 86 kDa disulfide-linked dimer; activation or reduction produces monomers.
  • Belongs to peptidase family A1.
10 A0A1L8H7D5 B7ZQ61 P14091 P16228 P25796 P43159 P70269 Q800A0 Q805F2 Q805F3