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CATH Superfamily 2.40.70.10

Acid Proteases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Acid Proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22819: Plasmepsin 1

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Plasmepsin II. [EC: 3.4.23.39]
Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves small molecules substrates such as Ala-Leu-Glu-Arg-Thr-Phe-|-Phe(NO(2))-Ser-Phe-Pro-Thr.
  • Inhibited by pepstatin.
  • Belongs to peptidase family A1.
 17 A0A024V0R3 A0A024VFK3 A0A024VZX4 A0A024WIG0 A0A024X1I5 A0A060RYK2 A0A0L7K5Z5 P46925 Q17SC2 Q17SC5
(7 more...)
Plasmepsin I. [EC: 3.4.23.38]
Hydrolysis of the 33-Phe-|-Leu-34 bond in the alpha-chain of hemoglobin, leading to denaturation of molecule.
  • Inhibited by pepstatin.
  • Belongs to peptidase family A1.
 11 A0A024VEN8 A0A024W0P6 A0A024X0J3 A0A0L7K6M8 A0A144A171 P39898 Q17SC7 Q7KQM4 W7EV31 W7J5N4
(1 more...)