The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Acid Proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1328: Aspartic proteinase MKC7

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Yapsin 1. [EC: 3.4.23.41]
Hydrolyzes various precursor proteins with Arg or Lys in P1, and commonly Arg or Lys also in P2. The P3 amino acid is usually non-polar, but otherwise additional basic amino acids are favorable in both non- prime and prime positions.
  • Weakly inhibited by pepstatin.
  • Can partially substitute for kexin in a deficient strain of Saccharomyces cerevisiae.
  • The homologous product of the MKC7 gene (S.cerevisiae) has similar catalytic activity and has been termed yapsin 2.
  • Belongs to peptidase family A1.
1 P53379
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