The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Acid Proteases
".
FunFam 11579: Truncated pol polyprotein
There are 5 EC terms in this cluster
Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
EC Term | Annotations | Evidence |
---|---|---|
HIV-1 retropepsin.
[EC: 3.4.23.16]
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.
|
121 |
A0A0D3MKI1
A0A0D3MKI6
A0A0D3MKJ0
A0A0D3MKK1
A0A0D3MKK6
A0A0D3MKL2
A0A0D3MKL8
A0A0D3MKM4
A0A0D3MKM9
A0A0D3MKN3 (111 more...) |
RNA-directed DNA polymerase.
[EC: 2.7.7.49]
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
|
84 |
A0A075LUU0
A0A075LUX1
A0A075LVD3
A0A075LVG2
A0A075LVI0
A0A075LVN8
A0A075LVQ8
A0A075LVT6
A0A075LW84
A0A075LWA8 (74 more...) |
Retroviral ribonuclease H.
[EC: 3.1.26.13]
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
|
5 | O12158 P04588 Q75002 Q9QBZ5 Q9WC63 |
DNA-directed DNA polymerase.
[EC: 2.7.7.7]
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
|
5 | O12158 P04588 Q75002 Q9QBZ5 Q9WC63 |
Exoribonuclease H.
[EC: 3.1.13.2]
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
|
5 | O12158 P04588 Q75002 Q9QBZ5 Q9WC63 |