View in Gene3D

CATH Superfamily 2.40.50.100

RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

This superfamily comprises a barrel-sandwich hybrid domain, also known as the sandwich-barrel hybrid motif (SBHM), which is found in a variety of protein structures. Members of this superfamily include the lipoyl and biotinyl domains from adaptor/membrane fusion proteins from the RND (resistance nodulation cell division) family of bacterial efflux pumps (such as BesA, MexA, AcrA, EmrA, CusB, ZneB and MacA), the SBHM domain from the beta subunit in DNA-dependent RNA polymerases (such as in Escherichia coli Ec-beta and Thermus aquaticus Taq-beta), V-type ATP synthases, and ribosomal protein L27.

Pfam clan [PfamClan:CL0105],PMID:24996185,PMID:23334411,PMID:16154587,PMID:15340170

GO Diversity

Unique GO annotations
455 Unique GO terms

EC Diversity

Unique EC annotations
133 Unique EC terms

Species Diversity

Unique species annotations
26370 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 560
Domain clusters (>95% seq id): 94
Domain clusters (>35% seq id): 55
Unique PDBs: 254
Alignments
Structural Clusters (5A): 10
Structural Clusters (9A): 5
FunFam Clusters: 174
Function
Unique EC: 133
Unique GO: 455
Taxonomy
Unique Species: 26370