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CATH Superfamily 2.40.10.10

Trypsin-like serine proteases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Trypsin-like serine proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 47461: Kallikrein 1-related peptidase b5

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Tissue kallikrein. [EC: 3.4.21.35]
Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.
  • Formed from tissue prokallikrein by activation with trypsin.
  • A large number of tissue kallikrein-related sequences have been reported for rats and mice, though fewer seem to exist in other mammals.
  • The few that have been isolated and tested on substrates include mouse EC 3.4.21.54, submandibular proteinase a, epidermal growth- factor-binding protein, nerve growth factor gamma-subunit, rat tonin, submaxillary proteinases A and B, T-kininogenase, kallikreins K7 and K8.
  • The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-|-Xaa bonds.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.21.8.
 28 A0A0B6VSQ6 A0A0B6VSQ6 P00756 P00756 P00758 P00758 P12323 P12323 P15945 P15945
(18 more...)
Coagulation factor IXa. [EC: 3.4.21.22]
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
  • The proenzyme factor IX is activated by EC 3.4.21.27.
  • Belongs to peptidase family S1.
 26 A0A061HZH1 A0A061HZH1 P00740 P00740 P00741 P00741 P16291 P16291 P16292 P16292
(16 more...)