The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Trypsin-like serine proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
46546
26386
EC
3D
1sotA02 - 84.7
46854
26066
EC
3D
1sotA01 - 91.6
46969
11851
EC
3D
3qo6A02 - 88.6
46288
9850
EC
3D
3dfjA01 - 86.0
46570
6911
EC
3D
1a1rA02 - 95.6
46285
5657
EC
3D
1h4wA01 - 94.1
47738
1842
EC
3D
2as9A01 - 97.2
47593
1785
EC
3D
2oq5A02 - 90.7
47764
1673
EC
3D
1boqA01 - 94.9
47808
1569
EC
3D
1boqA02 - 94.0
3834
1458
EC
3D
2psxA01 - 81.4
46307
1356
EC
- - 87.7
10019
1248
EC
- - 14.9
47573
1247
EC
3D
4h4fA02 - 86.0
46999
1240
EC
3D
1ky9A01 - 93.6
46619
Adipsin
1033
EC
3D
1bioA01 - 91.3
47656
896
EC
3D
1gvlA02 - 93.2
46974
816 - - 89.8
47669
805
EC
3D
4dg4A02 - 83.7
47462
802
EC
3D
1qy6A02 - 97.9
46106
760
EC
3D
4dgjA01 - 80.1
46042
718
EC
3D
1a2cH01 - 80.8
46940
708 - - 74.8
47113
689
EC
3D
1kxaA02 - 86.3
46566
Hageman factor
647
EC
3D
1bmlA01 - 89.8
46843
641
EC
3D
1c5wB01 - 70.6
47067
600
EC
3D
1c5wB02 - 92.0
20014
586
EC
3D
1uj1A01 - 28.0
46595
583
EC
- - 90.7
46604
578
EC
3D
1au8A01 - 95.5
46292
542
EC
3D
4h4fA01 - 83.5
47490
519
EC
3D
1lcyA01 - 76.2
46333
502
EC
3D
1a2cH02 - 57.8
46527
451
EC
3D
1ltoA01 - 93.3
47386
450
3D
2as9A02 - 74.6
27757
445
EC
3D
3iwmB01 - 12.1
46939
423
EC
- - 82.5
47558
382
EC
3D
3s9aA02 - 79.5
46871
381
EC
3D
1fizA01 - 84.8
47796
373
EC
3D
1dleA01 - 81.1
46944
362
EC
3D
1z8rA02 - 98.5
46927
357
EC
3D
1q3xA02 - 96.4
47500
342
EC
3D
2vb0A02 - 95.4
47660
322
EC
- - 64.8
46098
318
EC
3D
1c5mD01 - 57.2
46587
301
EC
3D
2vb0A01 - 84.7
46746
294
EC
3D
1gpzA03 - 88.1
27762
260 - - 0.0
46909
253
EC
3D
1vcpA01 - 85.1
46863
245
EC
- - 92.7
46391
238
EC
3D
2iphA01 - 31.5
47461
220
EC
3D
1rfnA02 - 86.2
20674
211
3D
4inkA02 - 28.4
45921
210 - - 79.1
47769
204
EC
- - 93.5
46119
203
EC
3D
1b0eA01 - 74.8
46858
202
EC
3D
2fp7B02 - 86.6
15478
193
3D
2asuB02 - 89.5
47563
191
EC
3D
1bmlA02 - 90.9
47618
187
EC
- - 87.3
46035
164
EC
- - 86.9
47646
159
EC
3D
2hntE00 - 96.1
47668
153
EC
- - 89.9
46615
148
EC
3D
1lvbA02 - 99.3
46633
146 - - 67.4
28822
140
EC
- - 52.6
21072
134
3D
2w7sA02 - 29.3
551
129
EC
- - 74.7
47647
126
EC
- - 93.2
46723
126
EC
3D
3qo6A01 - 74.4
1852
124
EC
3D
1rfnA01 - 50.4
45977
Neurotrypsin, motopsin
123 - - 68.4
47522
122
3D
2xxlA03 - 73.7
47311
120
EC
- - 86.4
46911
116
EC
3D
3fanA01 - 77.0
46051
115
3D
2asuB01 - 66.9
46993
112 - - 81.1
46036
107
EC
3D
1dleA02 - 56.9
47497
107 - - 92.9
46674
105 - - 39.2
47605
105
EC
- - 88.1
47006
102
EC
3D
1kltA02 - 83.7
47599
97 - - 65.1
22417
97 - - 28.1
46388
97
EC
3D
4dgjA02 - 77.4
23404
96
EC
- - 0.0
47816
95
EC
- - 83.4
14014
95
EC
- - 14.5
46913
95 - - 75.0
46018
94 - - 76.4
46807
92 - - 28.5
46889
Quinone
88
3D
4wjg203 - 68.3
46591
88 - - 58.8
1369
86 - - 87.8
45996
85 - - 66.0
46936
81 - - 92.2
12519
77
EC
- - 25.1
46755
76
EC
3D
2hrvA01 - 62.0
1252
74 - - 29.7
46340
72 - - 72.5
46398
71 - - 39.7
46844
70 - - 73.9
45919
70 - - 58.8
1518
66
EC
- - 47.2
45942
65 - - 62.2
46045
63 - - 84.9
47643
62 - - 78.2
17007
Protease IV PvdS-regulated endoprotease
57
EC
- - 5.9
27758
55
3D
3k6yA01 - 9.1
21195
53
3D
3k6yA02 - 9.8
46559
53
EC
- - 81.0
46687
52
EC
3D
2bhgA02 - 43.5
46860
51 - - 80.6
29369
51
3D
1ab9B00 - 24.7
46178
50 - - 34.7
46507
50
3D
4f4oC03 - 71.1
1124
50
EC
- - 0.0
46581
49
EC
- - 85.8
46901
49
EC
- - 41.8
46916
49
3D
1kdqA00 - 85.8
47333
49
EC
3D
2xrcA04 - 54.1
46348
47 - - 35.2
46160
45 - - 47.3
46382
45 - - 34.5
46140
45 - - 58.8
47710
45 - - 54.2
46025
44 - - 45.0
20651
43
EC
3D
2j92A01 - 30.5
46159
42
EC
3D
3d23A01 - 24.5
14679
42
EC
- - 5.9
6069
41 - - 33.6
1165
40 - - 16.9
27364
39
EC
3D
1eawA02 - 17.2
21364
37 - - 42.2
46528
37
EC
- - 38.2
46473
36
3D
3tjuA02 - 53.0
47560
36 - - 87.2
46089
35 - - 55.9
28132
34
EC
3D
2q6dA01 - 48.0
19067
33
EC
3D
1havA02 - 16.0
47689
33
EC
3D
1q3xA03 - 50.0
46652
32
EC
3D
1kxaA01 - 36.4
925
31 - - 7.9
46864
30 - - 75.0
4692
29 - - 61.9
47644
28 - - 82.8
20008
28
EC
3D
1havA01 - 19.2
23955
27
EC
3D
2w5eA01 - 42.0
46556
27
3D
3f1sB03 - 72.6
23862
27
EC
- - 17.4
46072
27 - - 32.5
2013
26 - - 41.3
46000
26 - - 71.6
20656
25
EC
3D
2q6dC01 - 23.8
46301
24
EC
3D
3tloA02 - 52.8
17455
24
EC
- - 44.0
46132
24 - - 77.3
27087
24 - - 7.2
47877
23 - - 63.1
46008
23 - - 49.9
46170
23 - - 54.7
47575
22
3D
2hntC00 - 59.1
47101
21
EC
- - 84.8
5535
20 - - 20.9
47561
20 - - 64.9
6751
19 - - 40.9
15229
18
3D
1wthD01 - 0.0
7027
18 - - 53.3
22512
18
EC
- - 19.0
10431
17
EC
- - 44.2
46677
17 - - 60.6
47532
16
EC
- - 56.4
932
16 - - 1.3
46150
15 - - 50.6
46547
15
3D
1lcyA02 - 38.7
20007
14
EC
- - 8.7
28129
14
EC
- - 15.0
46439
14 - - 27.3
28900
14
EC
- - 15.9
46217
14
3D
3govB02 - 33.4
6689
14 - - 25.3
46225
13
EC
- - 12.9
21040
13
EC
- - 16.7
20575
13
3D
1mzaA02 - 21.4
7000
13 - - 12.4
46947
12 - - 58.5
28134
12
EC
3D
4xfqA01 - 13.4
46545
12 - - 46.1
47847
12 - - 44.1
46792
12 - - 19.3
47182
12
3D
1m9uA01 - 32.0
47655
12
EC
- - 74.8
46833
11
EC
- - 60.9
20273
11
EC
- - 20.1
25847
11 - - 3.0
45926
11
EC
3D
1autC01 - 36.5
5972
11 - - 11.7
1533
11
EC
- - 19.4
20998
10 - - 2.0
32567
10
EC
- - 15.5
38105
10 - - 10.2
9702
10 - - 14.7
46603
10 - - 69.9
46101
10
EC
- - 21.9
45835
10 - - 23.1
6154
9 - - 4.3
46832
9 - - 23.4
32236
9 - - 17.6
15925
9
EC
- - 7.4
27329
9 - - 18.1
20400
9 - - 11.7
46371
8
EC
- - 36.7
13423
8 - - 9.2
47021
8
EC
- - 35.1
29462
8
EC
- - 21.4
253
8 - - 3.1
10440
8 - - 7.5
24274
8 - - 14.8
47432
8
EC
- - 55.4
10396
7 - - 4.7
29843
7 - - 1.1
18007
7 - - 6.1
47426
7 - - 24.2
34414
7 - - 19.9
4075
7
EC
- - 29.2
4232
7
EC
- - 28.4
34158
7 - - 16.7
32194
7
EC
3D
1mbmA02 - 5.1
4218
7 - - 46.0
46408
7 - - 33.9
5237
7 - - 27.5
345
S01 family
7 - - 45.2
1043
7 - - 15.6
46514
7 - - 18.5
26618
7
EC
- - 17.3
47694
7 - - 48.8
980
7 - - 6.1
24167
7
EC
- - 7.3
35131
7
3D
2i6sA02 - 17.7
46763
Hageman factor
6 - - 24.2
21201
6 - - 28.3
46291
6 - - 66.9
31869
6 - - 9.4
47795
6 - - 36.4
49
6 - - 31.4
20631
6 - - 29.2
46164
6
EC
- - 15.2
334
6 - - 7.0
46639
6 - - 72.7
46236
6
EC
- - 19.0
23787
6
EC
- - 11.7
46324
6
EC
- - 17.0
30407
6
EC
3D
1mbmA01 - 1.6
7547
6
EC
- - 18.2
46926
5
EC
- - 26.9
12483
5 - - 5.1
36740
5
EC
- - 15.1
12216
5 - - 14.7
4433
5 - - 0.7
7972
5 - - 15.7
1685
5 - - 4.7
24169
5
EC
- - 5.8
21720
5
EC
- - 0.0
46024
5 - - 9.6
47370
5
EC
- - 65.3
46001
5
EC
- - 24.6
27160
5 - - 6.6
46602
5 - - 31.3
17291
5 - - 1.3
47140
5 - - 0.0
46209
5 - - 7.2
25903
5 - - 19.5
20659
5
EC
- - 6.8
17691
5 - - 12.9
46125
5 - - 32.4
27516
5 - - 0.0
6860
5 - - 9.0
6417
5 - - 1.8
47354
4
EC
- - 38.4
4051
4 - - 7.1
46454
4
EC
- - 7.0
28142
4
EC
3D
3tloA01 - 0.0
47085
4 - - 8.3
46710
4 - - 31.6
28139
4
EC
3D
2zu2A01 - 9.5
7902
4 - - 5.8
47777
4 - - 32.6
6703
4 - - 9.6
46139
4
EC
- - 20.7
3227
4 - - 4.7
5695
4 - - 17.0
8962
4 - - 16.0
47465
4 - -
24630
4
EC
- - 29.1
19116
3 - - 5.2
46048
3 - - 10.0
5389
3 - - 5.4
28135
3
3D
3u1iB02 - 0.0
7835
3 - - 0.0
910
3 - - 19.3
34127
3 - - 5.5
47134
3 - - 38.9
29474
3 - - 4.9
26885
3 - - 8.3
27423
3
EC
- - 1.4
24624
3
EC
- - 5.0
20655
3
EC
- - 1.2
46130
3
EC
- - 17.6
34947
3 - - 0.0
21345
3
EC
- - 0.0
20654
3
EC
- - 3.5
46020
3
EC
- - 15.5
3269
3 - -
30735
2 - - 12.8
7329
2 - - 2.8
14835
2 - - 8.2
7862
2 - - 1.9
16355
2 - - 0.0
23553
2 - - 1.0
46034
2 - - 0.5
32560
2
EC
- - 5.6
46415
2 - - 13.4
9944
2 - - 19.8
4217
2 - - 11.5
270
2 - - 5.2
24626
2
EC
- - 0.0
34922
2
EC
- - 0.0
8763
2 - - 0.0
24177
2
EC
- - 2.5
10678
2 - - 7.8
20988
2 - - 9.8
45924
2 - - 8.2
11335
2 - - 0.9
24623
2
EC
- - 1.2
8417
2
EC
- - 0.9
47047
2 - - 0.0
4868
2 - - 0.0
7709
2 - - 8.3
22092
2
EC
- - 0.0
33322
2
EC
- - 0.0
23769
2
EC
- - 5.9
47690
2 - - 0.0
24631
2
EC
- - 4.6
37658
2 - - 8.0
30081
2
EC
- - 0.0
31840
2 - - 5.9
17292
2
EC
- - 5.2
47768
2
EC
- - 0.0
1290
2 - - 5.6
46806
2 - -
31567
2 - - 12.2
42449
2 - - 0.0
35221
2 - -
28136
2
EC
- - 0.0
32326
2 - - 0.5
8893
2 - - 0.0
47300
1 - - 0.0
26633
1
EC
- - 0.0
46418
1 - -
41272
1 - -
26642
1 - - 0.0
11899
1 - - 0.0
47463
1 - - 0.0
45978
1 - - 0.0
8979
1 - - 0.0
47190
1 - - 0.0
46155
1
EC
- - 0.0
30608
1 - - 0.0
46158
1
EC
- - 0.0
18374
1
EC
- - 0.0
47121
1
EC
- - 0.0
16116
1 - - 0.0
5859
1 - - 0.0
35230
1 - - 0.0
21006
1 - - 0.0
20661
1 - - 0.0
26639
1
EC
- - 0.0
39221
1 - - 0.0
47703
1
EC
- - 0.0
23816
1 - - 0.0
40380
1 - - 0.0
26911
1 - - 0.0
4407
1 - - 0.0
28460
1
EC
- - 0.0
22292
1 - -
26630
1 - - 0.0
1403
1 - - 0.0
33870
1 - - 0.0
22094
1 - - 0.0
35360
1
EC
- - 0.0
46775
1 - - 0.0
16347
1
EC
- - 0.0
46188
1 - - 0.0
24175
1
EC
- - 0.0
5016
1 - - 0.0
33654
1 - - 0.0
37379
1 - - 0.0
12446
1 - -
23071
1
EC
- - 0.0
8675
1 - - 0.0
12021
1 - - 0.0
25690
1 - - 0.0
45916
1 - - 0.0
20344
1
EC
- - 0.0
45340
1 - - 0.0
14633
1
EC
- - 0.0
735
1 - - 0.0
18743
1 - - 0.0
46551
1 - - 0.0
11406
1 - - 0.0
216
1 - - 0.0
35396
1 - - 0.0
24171
1
EC
- - 0.0
9711
1 - - 0.0
12450
1 - - 0.0
30584
1 - - 0.0
31957
1 - - 0.0
23447
1 - - 0.0
15834
1 - - 0.0
28811
1
EC
- - 0.0
31817
1
EC
- - 0.0
16356
1
EC
- - 0.0
16351
1
EC
- - 0.0
34531
1 - - 0.0
7891
1 - - 0.0
24178
1
EC
- - 0.0
40595
1 - -